KR840003695A - 항생물질의 제조방법 - Google Patents

항생물질의 제조방법 Download PDF

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KR840003695A
KR840003695A KR1019830000743A KR830000743A KR840003695A KR 840003695 A KR840003695 A KR 840003695A KR 1019830000743 A KR1019830000743 A KR 1019830000743A KR 830000743 A KR830000743 A KR 830000743A KR 840003695 A KR840003695 A KR 840003695A
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compound
magnetic resonance
mhz
ppm
spectrum
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KR1019830000743A
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KR880002688B1 (ko
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에스.스탬프와라 수레쉬
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제리 에이.웨이스바쉬
와르너-람베르트 컴페니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

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  • Chemical & Material Sciences (AREA)
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Abstract

내용 없음

Description

항생물질의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 다음식 1,2a 및 2b를 지니는 CL-1565A, CL1565-B 및 CL1565-T로 나타내는 인함유항생물 및 제약적으로 알맞는 그 염으로서, (a)259와 278㎚에서 굴절을 지닌 λmax268㎚(ai=805)를 지니는 메탄올에서 자외선 흡수스펙트럼, (b)주요흡수:3400,1710,1630,1420,1387,1260,1155,1090,1060,975,920,820 및 775㎝-1을 지니는 KBr에서 적외선 흡수 스펙트럼. (c)광학적 회전[]D+28.2(0.1M pH7인산염 완충액에서 1.0%). (d)475와 453에서 m/Z피크를 지니는 매스 스펙트럼(고정원자 폭발을 통함). (e)주요 신호시(s=단일, d=이중, t=삼중, m=다중) 1.29s(3H), 1.85t(1H), 1.70m(1H, 2.49-2.58m)(2H), 4.13-4.18m(3H), 4.86t(1H), 5.53t(1H), 5.9-6.0m(4H), 6.14t(1H), 6.32t(1H), 6.55t(1H), 6.75dd(1H) 및 7.09m(1H) DSS에서 ppm을 지니는 D20에서 360MHz 양자 자기 공명 스펙트럼.
    (f)주요 신호:
    168.4 79.5 149.8 79.0 138.1 75.6 135.0 64.4 134.4 64.4
    131.3 62.9 127.4 39.4 126.7 26.7 124.9 23.5 124.8ppm을 TMS에서 지니는 D20에서 120.1 13C-핵자기 공명 스펙트럼으로 특징지어지는 나트륨염을 지니는 CL1565-A 화합물, (a)260과 278㎜에서 굴절과 λmax268㎚(ai=774)를 지니는 메탄올에서 자외선 흡수 스펙트럼 (b)주요흡수:3400,1715,1630,1380,1260,1090,970,830 및 770㎝-1을 지니는 KBr내에서 적외선 흡수 스펙트럼 (c)491에서 m/Z피크를 지니는 매스 스펙트럼(고정원자 폭발을 통함) (d)주요 흡수 스펙트럼(s=단일, d=이중, t=삼중, m=다중), 1.30s(3H, 1.55-1.64m(1H), 1.73t(1H), 4.13-4.20m(1H), 4.16d(2H), 4.34dd(1H), 4.94t(1h), 5.09dd(1H), 5.55t(1H), 5.89-6.06m(3H), 6.16m(2H), 6.36t(1H), 6.56t(1H), 6.76dd(1H), 7.14dd(1H)ppm DSS에서 지니는 D20내 360MHz양과 자기 공명 스펙트럼 (e)다음의 D20내 90.4MHz 13C-핵자기 공명 스펙트럼:
    *TMS에서 ppm로 특징지어지는 나트륨염을 지니는 CL1565-T (a)259와 277㎚에서 굴절을 지니는 λmax267㎚(ai=805)를 지니는 메탄올내 자외선흡수스펙트럼, (b)주요흡수:1720,1640,1395,1200,1060,970 및 820㎝-1를 지니는 KBr내 적외선 흡수 스펙트럼. (c)주요신호(s=단일, d=이중, t=삼중, m=다중), 1.32s(3H), 1.58t(1H), 1.72t(1H), 1.79d(3H), 2.45-2.68m(1H), 4.15t(1H), 4.89t(1H), 5.10m(1H), 5.49t(1H), 5.83-6.21m(6H), 6.50-6.64m(2H), 7.06-7.13m(1H)ppm(DSS에서)를 지니는 D20내 360MHz양과 자기 공명 스펙트럼 (e)다음의 D20내 90.4MHz 13C-핵자기 공명 스펙트럼:
    * ppm에서 으로 특징지어진 화합물.
  2. 청구범위 제1항에 있어서 CL1565-A인 화합물.
  3. 청구범위 제1항에 있어서 CL1565-B인 화합물.
  4. 청구범위 제1항에 있어서 CL1565-T인 화합물.
  5. 청구범위 제1항에 있어서 CL1565 혼합물을 생산하는 스트렙토마이세스종 ATCC31906을 CL1565 화합물이 실질적인 양만큼 생산될때까지 배양하고 유리산 혹은 염형태로 분리하는 단계로 구성되는 최소한 하나의 CL1565화합물을 제조하는 방법.
  6. 최소한 하나의 CL1565-A, CL1565-B 및 CL1565-T와 제약학적으로 알맞는 염 및 제약학적으로 알맞는 담체로 구성되는 제약학적 조성물.
  7. 청구범위 제1항에 있어서 CL1565-A 나트륨염인 화합물.
  8. 청구범위 제1항에 있어서 CL1565-B 나트륨염인 화합물.
  9. 청구범위 제1항에 있어서 CL1565-T 나트륨염인 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830000743A 1982-02-24 1983-02-24 항생물질의 제조방법 KR880002688B1 (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US35170482A 1982-02-24 1982-02-24
US351704 1982-02-24
US351.704 1982-02-24
US43997382A 1982-11-08 1982-11-08
US439973 1982-11-08
US439,973 1982-11-08
US44754482A 1982-12-07 1982-12-07
US447,544 1982-12-07
US447544 1982-12-07

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KR840003695A true KR840003695A (ko) 1984-09-15
KR880002688B1 KR880002688B1 (ko) 1988-12-20

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EP (1) EP0087021B1 (ko)
KR (1) KR880002688B1 (ko)
DE (1) DE3371997D1 (ko)
DK (1) DK165983C (ko)
ES (1) ES520015A0 (ko)
GR (1) GR77180B (ko)
IE (1) IE54287B1 (ko)
PT (1) PT76278B (ko)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0128651A3 (en) * 1983-05-12 1987-01-07 Warner-Lambert Company Pyranones and related compounds and methods for their production and use
CA1232852A (en) * 1983-09-12 1988-02-16 Gerard C. Hokanson Cl-1957b antibiotic compound and its production
AU574713B2 (en) * 1983-09-12 1988-07-14 Warner-Lambert Company Cl-1957a antibiotic compound and its production
DE68924991T2 (de) * 1988-02-13 1996-07-11 Suntory Ltd 2-Pyranon-Derivat und Verfahren zu dessen Herstellung.
CN103626801A (zh) * 2008-04-03 2014-03-12 北京华昊中天生物技术有限公司 福司曲星衍生物、其药用用途及制备方法
CN103626800A (zh) * 2008-04-03 2014-03-12 北京华昊中天生物技术有限公司 福司曲星衍生物、其药用用途及制备方法
CN101550162B (zh) 2008-04-03 2015-11-25 北京华昊中天生物技术有限公司 福司曲星衍生物及其药用用途
CN108773948A (zh) * 2018-06-11 2018-11-09 佛山市顺德区唯点工业设计有限公司 一种环保污水高效安全治理装置

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* Cited by examiner, † Cited by third party
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US4237053A (en) * 1978-12-20 1980-12-02 Ortho Pharmaceutical Corporation Total synthesis of the utero-evacuant substance d,l-zoapatanol

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ES8403968A1 (es) 1984-04-01
DK75683D0 (da) 1983-02-22
EP0087021A2 (en) 1983-08-31
DE3371997D1 (en) 1987-07-16
DK75683A (da) 1983-08-25
DK165983B (da) 1993-02-22
IE54287B1 (en) 1989-08-16
KR880002688B1 (ko) 1988-12-20
PT76278A (en) 1983-03-01
ES520015A0 (es) 1984-04-01
PT76278B (en) 1986-01-17
DK165983C (da) 1993-07-26
EP0087021A3 (en) 1985-01-09
GR77180B (ko) 1984-09-11
IE830156L (en) 1983-08-24
EP0087021B1 (en) 1987-06-10

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