ES8301951A1 - "un metodo de produccion de derivados de tiazolidina". - Google Patents

"un metodo de produccion de derivados de tiazolidina".

Info

Publication number
ES8301951A1
ES8301951A1 ES508490A ES508490A ES8301951A1 ES 8301951 A1 ES8301951 A1 ES 8301951A1 ES 508490 A ES508490 A ES 508490A ES 508490 A ES508490 A ES 508490A ES 8301951 A1 ES8301951 A1 ES 8301951A1
Authority
ES
Spain
Prior art keywords
carbon atoms
thiazolidine derivatives
production
diabetic
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508490A
Other languages
English (en)
Other versions
ES508490A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Takeda Pharmaceutical Co Ltd
Original Assignee
Senju Pharmaceutical Co Ltd
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP755880A external-priority patent/JPS56104876A/ja
Priority claimed from JP10471880A external-priority patent/JPS5728075A/ja
Application filed by Senju Pharmaceutical Co Ltd, Takeda Chemical Industries Ltd filed Critical Senju Pharmaceutical Co Ltd
Publication of ES8301951A1 publication Critical patent/ES8301951A1/es
Publication of ES508490A0 publication Critical patent/ES508490A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE TIAZOLIDINA DE FORMULA (I), EN LA QUE R PUEDE SER VARIOS TIPOS DE RADICALES; Y R ES HIDROGENO O ALCOHILO C <003> . CONSISTE EN LA REACCION DE TIOUREA CON UN COMPUESTO DE FORMULA (II), EN LA QUE X ES HALOGENO O HIDROXI; Z PUEDE SER VARIOS RADICALES; Y R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), EN UN DISOLVENTE, A LA TEMPERATURA DE EBULLICION DEL DISOLVENTE; SEGUIDA DE LA HIDROLISIS DEL PRODUCTO OBTENIDO, EN UN DISOLVENTE ADECUADO, EN PRESENCIA DE AGUA Y DE ACIDO MINERAL, A UNA TEMPERATURA ELEVADA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA CATARATA DIABETICA Y LA NEUROPATIA DIABETICA.
ES508490A 1980-01-24 1981-12-31 "un metodo de produccion de derivados de tiazolidina". Granted ES508490A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP755880A JPS56104876A (en) 1980-01-24 1980-01-24 Thiazolidine derivative
JP10471880A JPS5728075A (en) 1980-07-29 1980-07-29 Thiazolidine derivative

Publications (2)

Publication Number Publication Date
ES8301951A1 true ES8301951A1 (es) 1982-12-16
ES508490A0 ES508490A0 (es) 1982-12-16

Family

ID=26341877

Family Applications (1)

Application Number Title Priority Date Filing Date
ES508490A Granted ES508490A0 (es) 1980-01-24 1981-12-31 "un metodo de produccion de derivados de tiazolidina".

Country Status (9)

Country Link
US (1) US4387101A (es)
EP (1) EP0033617A3 (es)
AR (1) AR228144A1 (es)
AU (1) AU6610081A (es)
DK (1) DK30781A (es)
ES (1) ES508490A0 (es)
GR (1) GR72992B (es)
PH (1) PH15937A (es)
PT (1) PT72390B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58177983A (ja) * 1982-04-13 1983-10-18 Takeda Chem Ind Ltd チアゾリジン誘導体
ATE45574T1 (de) * 1983-01-17 1989-09-15 Pfizer Aldosereduktasehemmende 5-(2alkoxyphenyl)thiazolidinedione.
US4617312A (en) * 1983-01-17 1986-10-14 Pfizer Inc. Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones
JPS6143114A (ja) * 1984-08-03 1986-03-01 Takeda Chem Ind Ltd 虹彩・毛様体疾患治療用眼局所投与剤
US5356917A (en) * 1985-08-09 1994-10-18 Eli Lilly And Company Aryl-substituted rhodanine derivatives
US5691367A (en) * 1985-08-09 1997-11-25 Eli Lilly And Company Aryl-substituted rhodanine derivatives
US5216002A (en) * 1989-12-21 1993-06-01 Eli Lilly And Company Method of treating inflammatory bowel disease
US5158966A (en) * 1991-02-22 1992-10-27 The University Of Colorado Foundation, Inc. Method of treating type i diabetes
EP0531529B1 (en) * 1991-03-27 1996-11-20 Senju Pharmaceutical Co., Ltd. Process for preparing aqueous suspension
ZA936492B (en) * 1992-09-10 1995-03-02 Lilly Co Eli Compounds useful as hypoglycemic agents and for treating Alzheimer's disease.
US6251928B1 (en) 1994-03-16 2001-06-26 Eli Lilly And Company Treatment of alzheimer's disease employing inhibitors of cathepsin D
JP3906935B2 (ja) * 1995-12-18 2007-04-18 杏林製薬株式会社 Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法
AU743411B2 (en) * 1998-08-21 2002-01-24 Viropharma Incorporated Compounds, compositions and methods for treating or preventing viral infections and associated diseases
EP1194146B1 (en) * 1999-06-18 2006-07-19 Merck & Co., Inc. Arylthiazolidinedione and aryloxazolidinedione derivatives
AR035016A1 (es) * 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
US6531461B1 (en) 2001-06-04 2003-03-11 Louis Obyo Obyo Nelson Medicament for the treatment of diabetes

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2255903A (en) * 1938-07-25 1941-09-16 Lilly Co Eli 5,5-disubstituted-2,4-thiazolidiones, and process of making them
FR909629A (fr) * 1944-05-25 1946-05-14 Ste Ind Chim Bale Procédé pour lutter contre les organismes nuisibles
US2678318A (en) * 1949-08-19 1954-05-11 Beecham Res Lab Preparation of alpha-amino acids
FR1222411A (fr) * 1955-05-19 1960-06-09 Searle & Co Procédé de préparation de 2,4-diaminothiazols contenant un radical aryle halogéné
NL125835C (es) * 1960-05-24
US3825553A (en) * 1970-05-05 1974-07-23 Rorer Inc William H Certain 5-arylthiazolidines
US3864384A (en) * 1970-05-05 1975-02-04 Rorer Inc William H Substituted phenylacetic acid compounds
YU37171B (en) * 1975-12-05 1984-08-31 Krka Novo Mesto Process for preparing 7-(d-2-amino-2-phenylacetamido)-3-methyl-3-cephem-4-carboxylic acid
DE2655369A1 (de) * 1976-12-03 1978-06-08 Schering Ag 5-(subst. phenyl)-oxazolidinone und deren schwefelanaloga sowie verfahren zu deren herstellung
DE2862059D1 (en) * 1977-12-29 1982-11-11 Synthelabo Thiazolidinedione-2,4 derivatives, their preparation and pharmaceutical applications
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative

Also Published As

Publication number Publication date
AU6610081A (en) 1981-07-30
GR72992B (es) 1984-01-23
DK30781A (da) 1981-07-25
PT72390B (en) 1981-12-21
AR228144A1 (es) 1983-01-31
US4387101A (en) 1983-06-07
PH15937A (en) 1983-04-29
EP0033617A2 (en) 1981-08-12
EP0033617A3 (en) 1981-08-26
PT72390A (en) 1981-02-01
ES508490A0 (es) 1982-12-16

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