KR840001342B1 - N-포밀 펩타이드로부터 포밀그룹 제거방법 - Google Patents

N-포밀 펩타이드로부터 포밀그룹 제거방법 Download PDF

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Publication number
KR840001342B1
KR840001342B1 KR8202080A KR820002080A KR840001342B1 KR 840001342 B1 KR840001342 B1 KR 840001342B1 KR 8202080 A KR8202080 A KR 8202080A KR 820002080 A KR820002080 A KR 820002080A KR 840001342 B1 KR840001342 B1 KR 840001342B1
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KR
South Korea
Prior art keywords
reaction
mentioned
formyl
peptide
hydrazine
Prior art date
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Expired
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KR8202080A
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English (en)
Korean (ko)
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KR830010053A (ko
Inventor
지오비오 빈센쪼
오나토 지오지오
부라치 리비오
만지아 알베르토
Original Assignee
윤영환
주식회사 대웅제약
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Application filed by 윤영환, 주식회사 대웅제약 filed Critical 윤영환
Publication of KR830010053A publication Critical patent/KR830010053A/ko
Application granted granted Critical
Publication of KR840001342B1 publication Critical patent/KR840001342B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/124—Hydrazinolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR8202080A 1981-05-13 1982-05-13 N-포밀 펩타이드로부터 포밀그룹 제거방법 Expired KR840001342B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT21674 1981-05-13
IT21674/81A IT1194795B (it) 1981-05-13 1981-05-13 Procedimento per la eliminazione del gruppo n-formile da peptidi n-formilati e da esteri di peptidi n-formilati

Publications (2)

Publication Number Publication Date
KR830010053A KR830010053A (ko) 1983-12-24
KR840001342B1 true KR840001342B1 (ko) 1984-09-19

Family

ID=11185195

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8202080A Expired KR840001342B1 (ko) 1981-05-13 1982-05-13 N-포밀 펩타이드로부터 포밀그룹 제거방법

Country Status (23)

Country Link
US (1) US4434097A (enExample)
JP (1) JPS5810546A (enExample)
KR (1) KR840001342B1 (enExample)
AT (1) ATA183082A (enExample)
AU (1) AU537275B2 (enExample)
BE (1) BE893074A (enExample)
CA (1) CA1244406A (enExample)
CH (1) CH648566A5 (enExample)
DE (1) DE3216512C2 (enExample)
DK (1) DK208082A (enExample)
ES (1) ES511760A0 (enExample)
FI (1) FI821412L (enExample)
FR (1) FR2505829B1 (enExample)
GB (1) GB2098220B (enExample)
GR (1) GR75497B (enExample)
IT (1) IT1194795B (enExample)
NL (1) NL8201821A (enExample)
NO (1) NO821585L (enExample)
NZ (1) NZ200583A (enExample)
PT (1) PT74892B (enExample)
SE (1) SE8202787L (enExample)
YU (1) YU93882A (enExample)
ZA (1) ZA823232B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4555362A (en) * 1983-06-20 1985-11-26 G. D. Searle & Co. Method and intermediates for producing α-L-aspartyl-L-phenylalanine
IT1190395B (it) * 1985-09-30 1988-02-16 Lark Spa Procedimento per la rimozione del gruppo formile da un estere di n-formil peptide o di n-formil amminoacido
ATE487486T1 (de) * 2002-05-24 2010-11-15 Medtronic Inc Polypeptid-spaltungsprozess

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1543610A1 (de) 1966-08-27 1969-07-31 Hoechst Ag Verfahren zur Herstellung von Aminosaeuren und Peptiden und deren Derivaten
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
JPS5823380B2 (ja) * 1974-12-05 1983-05-14 味の素株式会社 ホルミルキノ ダツリホウ
JPS5223001A (en) * 1975-08-14 1977-02-21 Ajinomoto Co Inc Process for elimination of formyl group

Also Published As

Publication number Publication date
IT8121674A0 (it) 1981-05-13
FR2505829B1 (fr) 1985-10-25
FI821412A7 (fi) 1982-11-14
CH648566A5 (it) 1985-03-29
JPS616080B2 (enExample) 1986-02-24
FI821412L (fi) 1982-11-14
US4434097A (en) 1984-02-28
NL8201821A (nl) 1982-12-01
AU8361282A (en) 1982-11-18
FR2505829A1 (fr) 1982-11-19
FI821412A0 (fi) 1982-04-23
ES8302633A1 (es) 1983-02-01
SE8202787L (sv) 1982-11-14
IT8121674A1 (it) 1982-11-13
ES511760A0 (es) 1983-02-01
BE893074A (fr) 1982-08-30
ZA823232B (en) 1983-03-30
AU537275B2 (en) 1984-06-14
YU93882A (en) 1985-08-31
PT74892A (en) 1982-06-01
PT74892B (en) 1984-08-02
DE3216512A1 (de) 1982-12-23
GR75497B (enExample) 1984-07-24
ATA183082A (de) 1989-04-15
DK208082A (da) 1982-11-14
GB2098220A (en) 1982-11-17
GB2098220B (en) 1984-08-15
IT1194795B (it) 1988-09-28
DE3216512C2 (de) 1986-09-11
NO821585L (no) 1982-11-15
NZ200583A (en) 1984-12-14
KR830010053A (ko) 1983-12-24
JPS5810546A (ja) 1983-01-21
CA1244406A (en) 1988-11-08

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CA1273749A (en) PREPARATION PROCESS OF N-FORMYL-.alpha.-ASPARTYL PHENYLALANINE
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US4006152A (en) ε-N-pyridyl-4-methyloxycarbonyllysine
JPS61197592A (ja) α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造方法

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