KR830009057A - Method for preparing 5- (aminoalkyl) -11-phenyl-5H-dibenzo [b, e] [1, 4] diazepine - Google Patents

Method for preparing 5- (aminoalkyl) -11-phenyl-5H-dibenzo [b, e] [1, 4] diazepine Download PDF

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Publication number
KR830009057A
KR830009057A KR1019820000419A KR820000419A KR830009057A KR 830009057 A KR830009057 A KR 830009057A KR 1019820000419 A KR1019820000419 A KR 1019820000419A KR 820000419 A KR820000419 A KR 820000419A KR 830009057 A KR830009057 A KR 830009057A
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South Korea
Prior art keywords
formula
compound
diazepine
dibenzo
phenyl
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KR1019820000419A
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Korean (ko)
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KR880001866B1 (en
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로이 테일러 2 챈들러
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알.피.울프
에이 에이취 로빈스 캄파니 인코포레이티드
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Publication of KR830009057A publication Critical patent/KR830009057A/en
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Publication of KR880001866B1 publication Critical patent/KR880001866B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

내용 없음No content

Description

5-(아미노알킬)-11-페닐-5H-디벤조[b,e][1,4]디아제핀의 제조방법Method for preparing 5- (aminoalkyl) -11-phenyl-5H-dibenzo [b, e] [1,4] diazepine

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (1)

a) O-니트로디페닐아민을 3-(1-프탈이미도)-1-클로로프로판 용액으로 환원적으로 알킬화시켜 일반식(II)의 N-3-(1-프탈이미도)프로필-O-니트로디페닐아민을 수득하고a) Reductive alkylation of O-nitrodiphenylamine with 3- (1-phthalimido) -1-chloropropane solution to give N-3- (1-phthalimido) propyl-O of formula (II) To obtain nitrodiphenylamine b) 상기에서 수득한 일반식(II)의 화합물을 환원시켜 일반식(III)의 N-[3-(1-프탈이미도)프로필]-O-아미노디페닐아민을 수득하고b) reduction of the compound of formula (II) obtained above yields N- [3- (1-phthalimido) propyl] -O-aminodiphenylamine of formula (III); c) 상기에서 수득한 일반식(III)의 화합물을 일반식(IV)의 벤조일클로라이드와 반응시켜 일반식(V)의 N-[3-(프탈이미도)프로필]-O-벤즈아미도디페닐아민을 수득하고c) N- [3- (phthalimido) propyl] -O-benzamidodi of Formula (V) by reacting the compound of Formula (III) obtained above with benzoyl chloride of Formula (IV) To obtain phenylamine d) 상기에서 수득한 일반식(V)의 화합물을 시클로디하이드레이트시켜 일반식(VI)의 5-(3-프탈이미도프로필)-11-페닐-5H-디벤조[b,e][1,4]디아제핀을 수득하고d) Cyclodihydrate of the compound of formula (V) obtained above to give 5- (3-phthalimidopropyl) -11-phenyl-5H-dibenzo [b, e] [1, 4] to obtain diazepine e) 상기에서 수득한 화합물(VI)의 화합물을 히드라진과 반응시켜 R1및 R2가 모두 수소인 일반식(VII)의 5-(3-아미노프로필)-1-페닐-5H-디벤조[b,e][1,4]디아제핀을 수득하고e) 5- (3-aminopropyl) -1-phenyl-5H-dibenzo of general formula (VII) wherein R 1 and R 2 are both hydrogen by reacting the compound of compound (VI) obtained above with hydrazine [ b, e] [1,4] diazepine, f) 임의로 상기에서 수득된 일반식(VII)의 화합물을 (a) 트리에틸로토포르메이트 (b) NaBH4와 반응시켜 R1은 수소이고 R2는 메틸인 일반식(VIII)의 N-메틸-11-페닐-5H-디벤조[b,e][1,4]디아제핀-5-프로판아미드를 수득하는 것을 특징으로하여 일반식(I)의 화합물 및약리학적으로 무독한 그의 산부가염을 제조하는 방법f) optionally reacting a compound of formula (VII) obtained above with (a) triethyltoformate (b) NaBH 4 , wherein R 1 is hydrogen and R 2 is methyl N-methyl of formula (VIII) -11-phenyl-5H-dibenzo [b, e] [1,4] diazepine-5-propanamide, characterized in that the compound of formula (I) and its pharmacologically How to make 상기식에서, X는 수소, 염소, 브롬 또는 불소이고, R1및 R2는 모두 수소이거나 그하나가 메틸인 경우 다른 하나는 수소이다.Wherein X is hydrogen, chlorine, bromine or fluorine, and R 1 and R 2 are both hydrogen or when one is methyl the other is hydrogen. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR8200419A 1981-09-24 1982-02-02 Method for preparing 5(amino-alkyl)-phenyl-5h-dibenzo(b,e)(1,4)diazepines KR880001866B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30507681A 1981-09-24 1981-09-24
US305076 1981-09-24
US30576 1987-03-27

Publications (2)

Publication Number Publication Date
KR830009057A true KR830009057A (en) 1983-12-17
KR880001866B1 KR880001866B1 (en) 1988-09-23

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KR8200419A KR880001866B1 (en) 1981-09-24 1982-02-02 Method for preparing 5(amino-alkyl)-phenyl-5h-dibenzo(b,e)(1,4)diazepines

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JP (1) JPS5865280A (en)
KR (1) KR880001866B1 (en)
AT (1) AT383121B (en)
AU (2) AU549806B2 (en)
BE (1) BE891535A (en)
CA (1) CA1199325A (en)
CH (2) CH651028A5 (en)
DE (1) DE3149923A1 (en)
DK (1) DK531281A (en)
ES (1) ES507970A0 (en)
FI (1) FI813975L (en)
FR (1) FR2513249B1 (en)
GB (1) GB2106894B (en)
GR (1) GR75123B (en)
HK (1) HK85785A (en)
HU (1) HU187394B (en)
IE (1) IE51880B1 (en)
IL (1) IL64257A (en)
IN (1) IN155657B (en)
IT (1) IT1146729B (en)
LU (1) LU83798A1 (en)
NL (1) NL8105892A (en)
NO (1) NO813838L (en)
NZ (1) NZ198986A (en)
PH (1) PH16696A (en)
PL (1) PL234420A1 (en)
PT (1) PT74285B (en)
SE (1) SE448453B (en)
SG (1) SG65485G (en)
YU (1) YU43070B (en)
ZA (1) ZA818481B (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB907646A (en) * 1959-01-23 1962-10-10 Wander S A A Method of production of new derivatives of diazepin
AT228215B (en) * 1959-01-23 1963-07-10 Wander Ag Dr A Process for the production of new diazepine derivatives
AT226721B (en) * 1959-09-22 1963-04-10 Wander Ag Dr A Process for the preparation of new, 5-substituted diazepines
NL256049A (en) * 1959-09-22

Also Published As

Publication number Publication date
CH651028A5 (en) 1985-08-30
YU43070B (en) 1989-02-28
IT1146729B (en) 1986-11-19
ATA526981A (en) 1986-10-15
FR2513249A1 (en) 1983-03-25
FR2513249B1 (en) 1986-07-11
NO813838L (en) 1983-03-25
CH657126A5 (en) 1986-08-15
AT383121B (en) 1987-05-25
PL234420A1 (en) 1983-05-09
IL64257A0 (en) 1982-02-28
SE8106594L (en) 1983-03-25
SE448453B (en) 1987-02-23
GB2106894B (en) 1985-05-30
IN155657B (en) 1985-02-16
GR75123B (en) 1984-07-13
NL8105892A (en) 1983-04-18
FI813975L (en) 1983-03-25
LU83798A1 (en) 1983-09-01
GB2106894A (en) 1983-04-20
IE51880B1 (en) 1987-04-15
NZ198986A (en) 1986-02-21
PH16696A (en) 1984-01-06
DK531281A (en) 1983-03-25
HK85785A (en) 1985-11-08
HU187394B (en) 1985-12-28
ZA818481B (en) 1982-10-27
ES8207157A1 (en) 1982-09-01
PT74285A (en) 1982-02-01
ES507970A0 (en) 1982-09-01
AU7851381A (en) 1983-03-31
IE812770L (en) 1983-03-24
JPS5865280A (en) 1983-04-18
AU576010B2 (en) 1988-08-11
CA1199325A (en) 1986-01-14
KR880001866B1 (en) 1988-09-23
YU62482A (en) 1984-12-31
DE3149923A1 (en) 1983-04-14
SG65485G (en) 1986-05-02
AU4890585A (en) 1986-04-10
PT74285B (en) 1983-06-27
IL64257A (en) 1985-10-31
AU549806B2 (en) 1986-02-13
JPH0315637B2 (en) 1991-03-01
BE891535A (en) 1982-04-16
IT8168607A0 (en) 1981-12-10

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