KR830007596A - 3,4-비스-치환된 1,2,5-옥스디아졸 2-옥사이드의 제조방법 - Google Patents
3,4-비스-치환된 1,2,5-옥스디아졸 2-옥사이드의 제조방법 Download PDFInfo
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- KR830007596A KR830007596A KR1019810004968A KR810004968A KR830007596A KR 830007596 A KR830007596 A KR 830007596A KR 1019810004968 A KR1019810004968 A KR 1019810004968A KR 810004968 A KR810004968 A KR 810004968A KR 830007596 A KR830007596 A KR 830007596A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Materials For Photolithography (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 일반식(Ⅱ)의 히드록사모일클로라이드를 0° 내지 50℃에서 용매 또는 분산제에 도입시켜, HCl을 탈이시키고 이합체화시킴을 특징으로 하여 일반식(Ⅰ)의 3, 4-비스-치환된 1, 2, 5-옥스디아졸 2-옥사이드 및 그의 약물학적으로 무독한 산부가염을 제조하는 방법.상기식에서, R은 -NHR1, -NR2R3, -NHR4OR2, -NHR5COR6또는이고, R1은 탄소원자 1 내지 6의 알킬 또는 탄소원자 4 내지 7의 시클로알킬이며, R2및 R3는 탄소원자 1 내지 4의 알킬이고, R4는 -CnH2n- 인 알킬렌라디칼이며, n은 2,3 또는 4의 정수이고 R5는 일반식 -CmH2m-인 알킬렌 라디칼이며 m은 1,2 또는 3의 정수이고 R6는 -OR2, -NHR1, -NR2R3또는-NH2이고, X는 (CH2)p-, -(CH2)2- O-(CH2)2-또는이며 p는 4,5 또는 6의 정수이다.
- 제 1항에 있어서, 일반식(Ⅱ)의 히드록사모일클로라이드를 10 내지 25℃에서 용매 또는 분산제에 도입시킴을 특징으로 하는 방법.
- 제 1항 또는 제 2항에 있어서, 염기를 바람직하게는 동몰량 가함을 특징으로하는 방법.
- 제 1항 내지 제3항중의 어느 하나에 있어서, 라디칼 R이 -NH 그룹을 함유함을 특징으로하는 방법.
- 제 1항 내지 제4항중의 어느 하나에 있어서, R4가 -(CH2)2- 또는 -(CH2)3를 나타냄을 특징으로하는 방법.
- 제 1항 내지 제4항중의 어느 하나에 있어서, R5가 -CH2-또는 (CH2)2를 나타냄을 특징으로하는 방법.
- 제 1항 내지 제4항중의 어느 하나에 있어서, R2가 메틸 또는 에틸을 나타냄을 특징으로 하는 방법.
- 제 1항 내지 제7항중의 어느 하나에 있어서, 사용한 용매가 디메틸포름아미드, 디메틸설폭사이드, N-메틸피롤리돈, 저급알콜, 디에틸에테르, 물 또는 이들 용매의 혼합물인 것을 특징으로 하는 방법.
- 제 1항 내지 제9항중의 어느 하나에 있어서, 부가한 염기가 2금 또는 3급아민, 알칼리금속 히이드록사이드, 알칼리금속탄산염, 알칼리금속중탄산염 또는 알칼리금속 아세테이트인 것을 특징으로 하는 방법.
- 제 1항 내지 제9항중의 어느 하나에 있어서, 염기를 서서히 또는 소량씩 부가함을 특징으로 하는 방법.※참고사항:최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803047730 DE3047730A1 (de) | 1980-12-18 | 1980-12-18 | 3,4-bis-substituierte 1,2,5-oxdiazol-2-oxide, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische zubereitungen |
DE3047730.6 | 1980-12-18 | ||
DEP304773006 | 1980-12-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830007596A true KR830007596A (ko) | 1983-11-04 |
KR880000543B1 KR880000543B1 (ko) | 1988-04-13 |
Family
ID=6119497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019810004968A KR880000543B1 (ko) | 1980-12-18 | 1981-12-17 | 3,4-비스-치환된 1,2,5-옥스디아졸 2-옥사이드의 제조방법 |
Country Status (28)
Country | Link |
---|---|
US (1) | US4356178A (ko) |
EP (1) | EP0054872B1 (ko) |
JP (1) | JPS57123173A (ko) |
KR (1) | KR880000543B1 (ko) |
AR (1) | AR227697A1 (ko) |
AT (1) | ATE10094T1 (ko) |
AU (1) | AU542529B2 (ko) |
CA (1) | CA1157019A (ko) |
CS (1) | CS219863B2 (ko) |
DD (1) | DD201897A5 (ko) |
DE (2) | DE3047730A1 (ko) |
DK (1) | DK150597C (ko) |
ES (1) | ES508086A0 (ko) |
FI (1) | FI813666L (ko) |
GR (1) | GR81375B (ko) |
HK (1) | HK51385A (ko) |
HU (1) | HU183751B (ko) |
IE (1) | IE52034B1 (ko) |
IL (1) | IL64563A (ko) |
NO (1) | NO814045L (ko) |
NZ (1) | NZ199272A (ko) |
PH (1) | PH18051A (ko) |
PL (1) | PL128564B1 (ko) |
PT (1) | PT74129B (ko) |
RO (1) | RO84099B (ko) |
SG (1) | SG21285G (ko) |
SU (1) | SU1093246A3 (ko) |
ZA (1) | ZA818726B (ko) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4507485A (en) * | 1984-01-23 | 1985-03-26 | Bristol-Myers Company | 3,4-Disubstituted-1,2,5-oxadiazoles having histamine H2 -receptor antagonist activity |
DE4217794A1 (de) * | 1992-05-29 | 1993-12-02 | Cassella Ag | Phenylfuroxane |
DE4218582A1 (de) * | 1992-06-05 | 1993-12-09 | Cassella Ag | Pyridyl-1,2,5-oxadiazol-carbonamid-2-oxide |
DE4218979A1 (de) * | 1992-06-10 | 1993-12-16 | Cassella Ag | Pyrimidofuroxane |
DE4220264A1 (de) * | 1992-06-20 | 1993-12-23 | Cassella Ag | Phenyl-1,2,5-oxadiazol-carbonamid-2-oxide |
DE4223800A1 (de) * | 1992-07-20 | 1994-01-27 | Cassella Farbwerke Mainkur Ag | Verwendung von 1.2.5-Oxadiazol-2-oxiden zur Behandlung erektiler Dysfunktionen |
DE4307105A1 (de) * | 1993-03-06 | 1994-09-08 | Cassella Ag | Hydroxymethylfurazancarbonsäurederivate |
US5460669A (en) * | 1993-06-28 | 1995-10-24 | Thiokol Corporation | 3-nitramino-4-nitrofurazan and salts thereof |
DE4401150A1 (de) * | 1994-01-17 | 1995-07-20 | Cassella Ag | Furazancarbonsäurederivate |
JP2008543863A (ja) | 2005-06-15 | 2008-12-04 | ハイドラ バイオサイエンシズ インコーポレイテッド | 精子の運動亢進のモジュレーター及びその利用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4089867A (en) * | 1976-11-11 | 1978-05-16 | Texaco Inc. | Preparation of diacylfurazan oxides |
-
1980
- 1980-12-18 DE DE19803047730 patent/DE3047730A1/de not_active Withdrawn
-
1981
- 1981-10-06 DD DD81233917A patent/DD201897A5/de unknown
- 1981-11-18 FI FI813666A patent/FI813666L/fi not_active Application Discontinuation
- 1981-11-27 NO NO814045A patent/NO814045L/no unknown
- 1981-12-01 DK DK533881A patent/DK150597C/da not_active IP Right Cessation
- 1981-12-12 DE DE8181110399T patent/DE3167001D1/de not_active Expired
- 1981-12-12 AT AT81110399T patent/ATE10094T1/de not_active IP Right Cessation
- 1981-12-12 EP EP81110399A patent/EP0054872B1/de not_active Expired
- 1981-12-15 NZ NZ199272A patent/NZ199272A/en unknown
- 1981-12-15 PL PL1981234257A patent/PL128564B1/pl unknown
- 1981-12-15 PT PT74129A patent/PT74129B/pt unknown
- 1981-12-16 AR AR287828A patent/AR227697A1/es active
- 1981-12-16 GR GR66811A patent/GR81375B/el unknown
- 1981-12-16 SU SU3367545A patent/SU1093246A3/ru active
- 1981-12-16 IL IL64563A patent/IL64563A/xx unknown
- 1981-12-16 AU AU78558/81A patent/AU542529B2/en not_active Ceased
- 1981-12-17 KR KR1019810004968A patent/KR880000543B1/ko active
- 1981-12-17 ZA ZA818726A patent/ZA818726B/xx unknown
- 1981-12-17 CS CS819454A patent/CS219863B2/cs unknown
- 1981-12-17 JP JP56202598A patent/JPS57123173A/ja active Granted
- 1981-12-17 RO RO106033A patent/RO84099B/ro unknown
- 1981-12-17 ES ES508086A patent/ES508086A0/es active Granted
- 1981-12-17 IE IE2976/81A patent/IE52034B1/en unknown
- 1981-12-17 CA CA000392512A patent/CA1157019A/en not_active Expired
- 1981-12-18 US US06/332,234 patent/US4356178A/en not_active Expired - Fee Related
- 1981-12-18 PH PH26649A patent/PH18051A/en unknown
- 1981-12-18 HU HU813861A patent/HU183751B/hu unknown
-
1985
- 1985-03-21 SG SG212/85A patent/SG21285G/en unknown
- 1985-07-04 HK HK513/85A patent/HK51385A/xx unknown
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