KR830004305A - 아자테트라사이클릭 카보니트릴 - Google Patents

아자테트라사이클릭 카보니트릴 Download PDF

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Publication number
KR830004305A
KR830004305A KR1019800004093A KR800004093A KR830004305A KR 830004305 A KR830004305 A KR 830004305A KR 1019800004093 A KR1019800004093 A KR 1019800004093A KR 800004093 A KR800004093 A KR 800004093A KR 830004305 A KR830004305 A KR 830004305A
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KR
South Korea
Prior art keywords
lower alkyl
formula
azatetracyclic
compound
agitation
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KR1019800004093A
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English (en)
Inventor
블라트너 한스
스토르니 안겔로
Original Assignee
아놀드 자일러
시바 가이기 에이지
에른스트 알테르
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 아놀드 자일러, 시바 가이기 에이지, 에른스트 알테르 filed Critical 아놀드 자일러
Publication of KR830004305A publication Critical patent/KR830004305A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/14—[b,f]-condensed

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Water Treatment By Sorption (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Paper (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

아자테트라사이클릭 카보니트릴
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음 구조식(Ⅱ)를 갖는 디에탄올의 반응성 디에스테르를 다음 구조식(Ⅲ)의 화합물과 반응시키거나, 다음 구조식(Ⅳ)의 화합물을 시안화물과 반응시킴을 특징으로 하여 다음 구조식(Ⅰ)의 화합물, 이외 라세미체, 광학대장체 및 산부가염을 제조하는 방법.
    상기 구조식에서
    R은 수소, 저급알킬, 탄소수 10까지의 사이클로알킬-저급알킬, 저급알케닐, 저급알키닐, 하이드록시-저급알킬, 에테르화된 하이드록시 저급알킬, 또는 에스테르화된 하이드록시저급알킬이고,
    Hal은 할로겐이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800004093A 1979-12-10 1980-12-10 아자테트라사이클릭 카보니트릴 KR830004305A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1092879 1979-12-10
CH10928/79-9 1979-12-10

Publications (1)

Publication Number Publication Date
KR830004305A true KR830004305A (ko) 1983-07-09

Family

ID=4368292

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019800004693A KR850000610B1 (ko) 1979-12-10 1980-12-10 아자테트라사이클릭 카보니트릴의 제조방법
KR1019800004093A KR830004305A (ko) 1979-12-10 1980-12-10 아자테트라사이클릭 카보니트릴

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1019800004693A KR850000610B1 (ko) 1979-12-10 1980-12-10 아자테트라사이클릭 카보니트릴의 제조방법

Country Status (25)

Country Link
US (1) US4492691A (ko)
EP (1) EP0030916B1 (ko)
JP (1) JPS5692890A (ko)
KR (2) KR850000610B1 (ko)
AT (1) ATE9159T1 (ko)
AU (1) AU546197B2 (ko)
CA (1) CA1152987A (ko)
CY (1) CY1354A (ko)
DD (1) DD155617A5 (ko)
DE (1) DE3069086D1 (ko)
DK (1) DK157869C (ko)
ES (1) ES8200368A1 (ko)
FI (1) FI76575C (ko)
GB (1) GB2065120B (ko)
GR (1) GR72505B (ko)
HK (1) HK12887A (ko)
HU (1) HU187283B (ko)
IE (1) IE50583B1 (ko)
IL (1) IL61662A (ko)
KE (1) KE3683A (ko)
MY (1) MY8700558A (ko)
NO (1) NO154796C (ko)
NZ (1) NZ195795A (ko)
PT (1) PT72178B (ko)
ZA (1) ZA807692B (ko)

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3116283A (en) * 1963-12-31 Preparation of nitrogen heterocyclic
US3418339A (en) * 1966-04-04 1968-12-24 American Home Prod 10,11-epoxy-10,11-dihydro-5h-dibenzo[a,d] cycloheptene-5-carboxamides
CH501007A (de) * 1968-11-27 1970-12-31 Ciba Geigy Ag Verfahren zur Herstellung von neuen Thiepin- und Oxepinderivaten
CH501650A (de) * 1968-12-19 1971-01-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen Azepinderivaten
US3749790A (en) * 1969-11-12 1973-07-31 Ciba Geigy Corp Derivatives of dibenzo(b,f)pyrrolo-(3,4-d)azepine in compositions and a method for producing a c.n.s. depressant effect
DK134555B (da) * 1969-11-20 1976-11-29 Ciba Geigy Ag Analogifremgangsmåde til fremstilling af azepinderivater eller additionssalte deraf med uorganiske eller organiske syrer.
US3682959A (en) * 1969-12-23 1972-08-08 Hans Blattner BENZOTHIEPINO{8 4,5-c{9 {0 PYRROLES
US3777032A (en) * 1969-12-23 1973-12-04 Ciba Geigy Corp 2,3-dihydro-1h-thienobenozothiepino(4,5-c)pyrroles as cns-depressants
US3798237A (en) * 1969-12-23 1974-03-19 Ciba Geigy Corp Thiepin derivatives
CH532038A (de) * 1970-05-25 1972-12-31 Ciba Geigy Ag Verfahren zur Herstellung von neuen Cycloheptenderivaten
CH531535A (de) * 1970-05-26 1972-12-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen Thiepinderivaten
US3859439A (en) * 1970-05-26 1975-01-07 Ciba Geigy Corp 2,3-dihydro-5 -trifluoromethyl-1h-dibenzo(2,3:6,7) thiepino (4,5-c) pyrroles as cns-depressants
NL178593C (nl) * 1974-01-31 1986-04-16 Akzo Nv Werkwijze ter bereiding van een farmaceutisch preparaat op basis van een tetracyclische verbinding en werkwijze voor de bereiding van de daarbij te gebruiken tetracyclische verbindingen.
CH592095A5 (ko) * 1974-02-22 1977-10-14 Ciba Geigy Ag
US4112110A (en) * 1974-02-22 1978-09-05 Ciba-Geigy Corporation Oxygenated azatetracyclic compounds
SE405475B (sv) * 1974-03-06 1978-12-11 Du Pont Forfarande att framstella nya polycykliska derivat av pyrrolidin med lugnande och bedovande verkan
SE7501669L (sv) * 1974-04-05 1975-10-06 Ciba Geigy Ag Pyrrol-derivat och sett att framstella desamma.
CH624105A5 (en) * 1976-05-26 1981-07-15 Ciba Geigy Ag Process for the preparation of novel azatetracyclic compounds
NL7605526A (nl) * 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.

Also Published As

Publication number Publication date
ES497550A0 (es) 1981-11-01
PT72178A (de) 1981-01-01
GB2065120A (en) 1981-06-24
JPS5692890A (en) 1981-07-27
CA1152987A (en) 1983-08-30
JPH0320396B2 (ko) 1991-03-19
IE802575L (en) 1981-06-10
NZ195795A (en) 1984-11-09
ATE9159T1 (de) 1984-09-15
NO154796C (no) 1986-12-29
ZA807692B (en) 1981-12-30
AU546197B2 (en) 1985-08-22
KE3683A (en) 1987-01-30
NO803712L (no) 1981-06-11
DK157869B (da) 1990-02-26
PT72178B (de) 1981-10-28
US4492691A (en) 1985-01-08
DK525180A (da) 1981-06-11
FI803806L (fi) 1981-06-11
HUT34031A (en) 1985-01-28
EP0030916B1 (de) 1984-08-29
DD155617A5 (de) 1982-06-23
MY8700558A (en) 1987-12-31
KR850000610B1 (ko) 1985-05-01
CY1354A (en) 1987-04-24
IL61662A0 (en) 1981-01-30
AU6519680A (en) 1981-06-18
GR72505B (ko) 1983-11-15
FI76575B (fi) 1988-07-29
DE3069086D1 (de) 1984-10-04
GB2065120B (en) 1984-01-18
IL61662A (en) 1983-11-30
DK157869C (da) 1990-08-06
FI76575C (fi) 1988-11-10
ES8200368A1 (es) 1981-11-01
EP0030916A1 (de) 1981-06-24
NO154796B (no) 1986-09-15
IE50583B1 (en) 1986-05-14
HU187283B (en) 1985-12-28
HK12887A (en) 1987-02-20

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