KR830004256A - 치환된 3,6-비스(아미노알콕시) 아크리딘류의 제조방법 - Google Patents

치환된 3,6-비스(아미노알콕시) 아크리딘류의 제조방법 Download PDF

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Publication number
KR830004256A
KR830004256A KR1019800004119A KR800004119A KR830004256A KR 830004256 A KR830004256 A KR 830004256A KR 1019800004119 A KR1019800004119 A KR 1019800004119A KR 800004119 A KR800004119 A KR 800004119A KR 830004256 A KR830004256 A KR 830004256A
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KR
South Korea
Prior art keywords
hydrogen
aminoalkoxy
acridines
bis
preparing substituted
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KR1019800004119A
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English (en)
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KR840002088B1 (ko
Inventor
채드윅크 머독크 키이쓰
로버어트 다미아니 마아틴
에밀 더어 프레데릭
Original Assignee
죠 제이 헤이간
아메리카 사이아나밋드 캄파니
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Publication of KR830004256A publication Critical patent/KR830004256A/ko
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Publication of KR840002088B1 publication Critical patent/KR840002088B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

치환된 3,6-비스(아미노알콕시) 아크리딘류의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 하기구조식(Ⅱ)의 치환된 3,6-아크리딘디올디나트륨염을 2몰당량의 하기구조식(Ⅲ)의 알킬 할라이드와, 75°-100℃의 불활성용매내에서 응축이 실질적으로 일어나기에 충분한 시간동안 응축시키고: 원한다면 그의 금속복합체 또는 산부가염을 형성하는 것을 특징으로 하는 하기구조식(Ⅰ)의 제조방법.
    여기서 n은 1,2 또는 3 : R1및 R2는 각각 수소 또는 메틸 : R3및 R4는 같거나 다르고 수소 또는 C1-C4의 직쇄나 분지된 알킬 : 그리고 R3및 R4는 인접한 N(질소)과 함께 피롤리디노, 피페리디노, 모르폴리노 또는 N-메틸피페라지노; 그리고 R5, R6및 R7은 같거나 다르고 수소, 플로로, 클로로, 브로모 및 니트로이다 : 단 n이 1 또는 2이고 R1과 R2가 수소 또는 메틸이고 R3및 R4가 저급알킬일때는 R5, R6및 R7중 적어도 하나는 수소이 외의 치환체이어야 한다. X는 클로로 또는 브로모이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800004119A 1979-10-31 1980-10-28 치환된 3, 6-비스(아미노 알콕시) 아크리딘류의 제조방법 KR840002088B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8980579A 1979-10-31 1979-10-31
US89805 1998-06-03

Publications (2)

Publication Number Publication Date
KR830004256A true KR830004256A (ko) 1983-07-09
KR840002088B1 KR840002088B1 (ko) 1984-11-14

Family

ID=22219661

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800004119A KR840002088B1 (ko) 1979-10-31 1980-10-28 치환된 3, 6-비스(아미노 알콕시) 아크리딘류의 제조방법

Country Status (12)

Country Link
EP (1) EP0031407B1 (ko)
JP (1) JPS5673065A (ko)
KR (1) KR840002088B1 (ko)
AT (1) ATE26708T1 (ko)
AU (1) AU538477B2 (ko)
CA (1) CA1170260A (ko)
DE (1) DE3071953D1 (ko)
DK (2) DK460180A (ko)
ES (1) ES8106893A1 (ko)
HK (1) HK4491A (ko)
IE (1) IE52711B1 (ko)
ZA (1) ZA806195B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3582860D1 (de) * 1984-11-09 1991-06-20 American Cyanamid Co 3,6 bis(substituierte) acridinderivate.
JPH0263325U (ko) * 1988-10-31 1990-05-11
JPH0740447U (ja) * 1991-12-04 1995-07-18 天龍化学工業株式会社 箱形容器における注出口装置
US9139592B2 (en) 2010-06-14 2015-09-22 Trt Pharma Inc. Modulators of Nrf2 and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1727480A (en) * 1926-07-08 1929-09-10 Winthrop Chem Co Inc New dialkylamino-alkyl derivatives of the 3.6-dihydroxyacridine
DE490418C (de) * 1926-07-09 1930-02-05 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von basischen AEthern der Acridinreihe
US3740403A (en) * 1971-11-05 1973-06-19 American Cyanamid Co 3,6-bis-(dialkylaminoalkoxy)acridines
EP0012139A1 (en) * 1978-12-14 1980-06-25 American Cyanamid Company Therapeutic agent for stimulating the immune response in a mammal

Also Published As

Publication number Publication date
CA1170260A (en) 1984-07-03
AU6314180A (en) 1981-05-07
EP0031407A1 (en) 1981-07-08
HK4491A (en) 1991-01-18
IE802066L (en) 1981-04-30
EP0031407B1 (en) 1987-04-22
DK460180A (da) 1981-05-01
DK460080A (da) 1981-05-01
DE3071953D1 (en) 1987-05-27
AU538477B2 (en) 1984-08-16
JPH0259125B2 (ko) 1990-12-11
KR840002088B1 (ko) 1984-11-14
ES496412A0 (es) 1981-10-01
JPS5673065A (en) 1981-06-17
ATE26708T1 (de) 1987-05-15
ES8106893A1 (es) 1981-10-01
ZA806195B (en) 1982-05-26
IE52711B1 (en) 1988-02-03

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