KR830001916A - 구아니디노 티아졸 화합물의 제조방법 - Google Patents
구아니디노 티아졸 화합물의 제조방법 Download PDFInfo
- Publication number
- KR830001916A KR830001916A KR1019800000932A KR800000932A KR830001916A KR 830001916 A KR830001916 A KR 830001916A KR 1019800000932 A KR1019800000932 A KR 1019800000932A KR 800000932 A KR800000932 A KR 800000932A KR 830001916 A KR830001916 A KR 830001916A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- lower alkyl
- hydrogen atom
- formula
- alkyl group
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 구조식(A)의 화합물을 구조식 R1-NH2, R2-NH2또는 R4-NH2인 아민과 반응시킴을 특징으로 하여 구조식(Ⅰ)의 구아니디노티아졸 화합물을 제조하는 방법.상기 구조식중R은 수소원자 또는 저급알킬 그룹을 나타내고 Y는 유황원자나 메틸렌 그룹을 나타내며 m과 n은 각기 정수 1내지 3을 나타내고, A는또는 -CONH-R4로 나타내지는 그룹을 나타낸다(이 때 R1은 수소원자, 시아노그룹, 카바모일 그룹, 유레이도 그룹, 하이드록실 그룹, 저급 알콕시 그룹, 저급 아실그룹, 아실아미노그룹, 아릴 설파모일그룹, 아랄킬 그룹, 카복시메틸그룹 또는 -SO2-R3로 나타내지는 그룹[이 때 R3는 저급 알킬 그룹, 할로게노저급 알킬그룹, 비환된 또는 치환된 아릴그룹, 아미노그룹, 모노-또는 디-저급 알킬아미노그룹, 아릴아미노그룹, 아랄킬아미노 그룹을 나타낸다.]을 나타내며,R2는 수소원자, 저급 알킬그룹, 저급알케닐그룹, 저급알케닐 그룹, 시아노그룹 또는 저급 아실그룹을 나타내며,R4는 수소원자, 저급 알킬그룹, 하이드록실 그룹 또는 설파모일 그룹을 나타낸다.)R1는 저급 알킬 그룹을 나타내고,X는 산소원자, N-R1또는 N-R2를 나타낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2574579A JPS55118476A (en) | 1979-03-06 | 1979-03-06 | Novel amidine derivative and its preparation |
ZA00800970A ZA80970B (en) | 1979-03-06 | 1980-02-20 | Useful guanidinothiazole compounds,process for preparing them and medical compositions containing them |
AT0103080A AT374800B (de) | 1979-03-06 | 1980-02-25 | Verfahren zur herstellung neuer guanidinothiazole und von deren salzen |
PH23689A PH16099A (en) | 1979-03-06 | 1980-02-26 | Guanidinothiazole compounds,process for preparing them and medical composition containing them |
FI800591A FI70890C (fi) | 1979-03-06 | 1980-02-27 | Foerfarande foer framstaellning av farmakologiskt vaerdefulla guanidinotiazolfoereningar |
AU55975/80A AU534329B2 (en) | 1979-03-06 | 1980-02-28 | Guanioinothiazoles |
FR8004690A FR2450827A1 (fr) | 1979-03-06 | 1980-03-03 | Composes du guanidinothiazole utiles comme inhibiteurs des secretions d'acide gastrique, leurs procedes de preparation et les compositions medicales contenant de tels composes |
DE19803008056 DE3008056A1 (de) | 1979-03-06 | 1980-03-03 | Guanidinothiazolverbindungen, verfahren zu ihrer herstellung und arzneimittel |
GR61334A GR67011B (ko) | 1979-03-06 | 1980-03-03 | |
CH171680A CH644114A5 (de) | 1979-03-06 | 1980-03-04 | Guanidinothiazolverbindungen, verfahren zu ihrer herstellung und sie enthaltende arzneimittel. |
PT70899A PT70899A (en) | 1979-03-06 | 1980-03-04 | Process for preparing useful guanidinothiazole compounds |
CA000346986A CA1145345A (en) | 1979-03-06 | 1980-03-04 | Process for preparing guanidinothiazole compounds |
ES489222A ES489222A0 (es) | 1979-03-06 | 1980-03-05 | Un procedimiento para preparar un compuesto de guanidinotia-zol |
IT67346/80A IT1165509B (it) | 1979-03-06 | 1980-03-05 | Composti guanidino tiazolici particolarmente utili come inibitori di secrezione di acidi gastrici e procedimento per la loro preparazione |
BE2/58444A BE882071A (fr) | 1979-03-06 | 1980-03-05 | Composes du guanidinothiazole utiles comme inhibiteurs des secretions d'acide gastrique, leurs procedes de preparation et les compositions medicales contenant de tels composes |
SE8001691A SE447253B (sv) | 1979-03-06 | 1980-03-05 | Nya guanidinotiazolforeningar |
DK093580A DK157132C (da) | 1979-03-06 | 1980-03-05 | Analogifremgangsmaade til fremstilling af guanidinothiazolforbindelser eller syreadditionssalte deraf |
GB8007702A GB2052478B (en) | 1979-03-06 | 1980-03-06 | Guanidinothiazole compounds |
KR1019800000932A KR830002478B1 (ko) | 1979-03-06 | 1980-03-06 | 구아니디노 티아졸 화합물의 제조방법 |
YU622/80A YU42966B (en) | 1979-03-06 | 1980-03-06 | Process for obtaining guanidine thiazole compounds |
US06/127,902 US4362736A (en) | 1979-03-06 | 1980-03-06 | Guanidinothiazole compounds, and medical compositions containing them |
SI8010622A SI8010622A8 (sl) | 1979-03-06 | 1980-03-06 | Postopek pridobivanja gvanidintiazolnih spojin |
NL8001361A NL8001361A (nl) | 1979-03-06 | 1980-03-06 | Guanidinothiazoolverbindingen, werkwijzen ter bereiding ervan, alsmede farmaceutische preparaten die de guanidinothiazoolverbindingen bevatten. |
LTRP728A LT2242B (lt) | 1979-03-06 | 1993-06-30 | Guanidintiazoliniu junginiu gavimo budas |
LV930547A LV5493A3 (lv) | 1979-03-06 | 1993-11-30 | Guanidinotiazolu savienojumu iegusanas panemiens |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2574579A JPS55118476A (en) | 1979-03-06 | 1979-03-06 | Novel amidine derivative and its preparation |
KR1019800000932A KR830002478B1 (ko) | 1979-03-06 | 1980-03-06 | 구아니디노 티아졸 화합물의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830001916A true KR830001916A (ko) | 1983-05-19 |
KR830002478B1 KR830002478B1 (ko) | 1983-10-26 |
Family
ID=26363422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019800000932A KR830002478B1 (ko) | 1979-03-06 | 1980-03-06 | 구아니디노 티아졸 화합물의 제조방법 |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS55118476A (ko) |
KR (1) | KR830002478B1 (ko) |
BE (1) | BE882071A (ko) |
LT (1) | LT2242B (ko) |
ZA (1) | ZA80970B (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1150867A (zh) * | 1995-04-21 | 1997-05-28 | 索尼公司 | 具有电池容纳部的电子装置 |
JP6378179B2 (ja) * | 2013-07-03 | 2018-08-22 | 株式会社新日本科学 | 新規化合物,有機カチオントランスポーター3の検出剤及び活性阻害剤 |
-
1979
- 1979-03-06 JP JP2574579A patent/JPS55118476A/ja active Granted
-
1980
- 1980-02-20 ZA ZA00800970A patent/ZA80970B/xx unknown
- 1980-03-05 BE BE2/58444A patent/BE882071A/fr not_active IP Right Cessation
- 1980-03-06 KR KR1019800000932A patent/KR830002478B1/ko active
-
1993
- 1993-06-30 LT LTRP728A patent/LT2242B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JPS6157830B2 (ko) | 1986-12-09 |
JPS55118476A (en) | 1980-09-11 |
ZA80970B (en) | 1981-02-25 |
LT2242B (lt) | 1993-11-15 |
KR830002478B1 (ko) | 1983-10-26 |
BE882071A (fr) | 1980-09-05 |
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