KR20260011772A - 히노키티올 유사체, 이의 제조 방법 및 약제학적 조성물 - Google Patents

히노키티올 유사체, 이의 제조 방법 및 약제학적 조성물

Info

Publication number
KR20260011772A
KR20260011772A KR1020257043492A KR20257043492A KR20260011772A KR 20260011772 A KR20260011772 A KR 20260011772A KR 1020257043492 A KR1020257043492 A KR 1020257043492A KR 20257043492 A KR20257043492 A KR 20257043492A KR 20260011772 A KR20260011772 A KR 20260011772A
Authority
KR
South Korea
Prior art keywords
compound
salt
structural formula
following structural
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020257043492A
Other languages
English (en)
Korean (ko)
Inventor
마틴 디. 버크
앤서니 에스. 그릴로
알랙산더 쥐. 키오피
안나 산타마리아
다니엘 블레어
앤드류 블레이크
Original Assignee
더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 filed Critical 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈
Publication of KR20260011772A publication Critical patent/KR20260011772A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/717—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a seven- to twelve-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/733—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/22—Unsaturated compounds having a carboxyl group bound to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
KR1020257043492A 2018-04-13 2019-04-12 히노키티올 유사체, 이의 제조 방법 및 약제학적 조성물 Pending KR20260011772A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862657127P 2018-04-13 2018-04-13
US62/657,127 2018-04-13
PCT/US2019/027314 WO2019200314A2 (en) 2018-04-13 2019-04-12 Hinokitiol analogues, methods of preparing and pharmaceutical compositions thereof
KR1020207032644A KR102907811B1 (ko) 2018-04-13 2019-04-12 히노키티올 유사체, 이의 제조 방법 및 약제학적 조성물

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020207032644A Division KR102907811B1 (ko) 2018-04-13 2019-04-12 히노키티올 유사체, 이의 제조 방법 및 약제학적 조성물

Publications (1)

Publication Number Publication Date
KR20260011772A true KR20260011772A (ko) 2026-01-23

Family

ID=68163807

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020257043492A Pending KR20260011772A (ko) 2018-04-13 2019-04-12 히노키티올 유사체, 이의 제조 방법 및 약제학적 조성물
KR1020207032644A Active KR102907811B1 (ko) 2018-04-13 2019-04-12 히노키티올 유사체, 이의 제조 방법 및 약제학적 조성물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020207032644A Active KR102907811B1 (ko) 2018-04-13 2019-04-12 히노키티올 유사체, 이의 제조 방법 및 약제학적 조성물

Country Status (8)

Country Link
US (1) US12084411B2 (https=)
EP (1) EP3773900A4 (https=)
JP (1) JP7503310B2 (https=)
KR (2) KR20260011772A (https=)
CN (1) CN112672786A (https=)
AU (2) AU2019252933B2 (https=)
CA (1) CA3095945A1 (https=)
WO (1) WO2019200314A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019252933B2 (en) 2018-04-13 2025-09-04 The Board Of Trustees Of The University Of Illinois Hinokitiol analogues, methods of preparing and pharmaceutical compositions thereof
EP4045025A4 (en) * 2019-10-16 2023-11-22 Kinesid Therapeutics, Inc. TROPOLONE DERIVATIVES AND THEIR TAUTOMERS FOR IRON REGULATION IN ANIMALS
US20230406803A1 (en) * 2019-10-16 2023-12-21 Kinesid Therapeutics, Inc Tropolone derivatives and tautomers thereof for iron regulation in animals
CN114436909B (zh) * 2022-01-26 2023-05-30 河南科技大学 一种磺酰基桧木醇类衍生物及其制备方法和应用
CN115093356B (zh) * 2022-06-21 2024-02-23 广东医科大学 一种铁死亡诱导剂的制备方法与应用
JP2025531628A (ja) * 2022-09-30 2025-09-22 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ 神経変性疾患の処置方法
CN120282778A (zh) * 2022-09-30 2025-07-08 伊利诺伊大学评议会 氘化扁柏酚衍生物
CN117547525A (zh) * 2023-12-29 2024-02-13 中国科学院长春应用化学研究所 天然产物小分子桧木醇在制备治疗非酒精性脂肪性肝炎药物中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4066784A (en) 1976-06-17 1978-01-03 Ayerst, Mckenna And Harrison Ltd. Tropone derivatives
US4183955A (en) 1976-06-17 1980-01-15 Ayerst. McKenna & Harrison Limited Troponyl-oxamic acid derivatives for treating allergic conditions
JP2552870B2 (ja) * 1986-08-21 1996-11-13 塩野義製薬株式会社 抗マイコプラズマ剤および抗マイコプラズマ活性を有する化合物
JP2622836B2 (ja) * 1987-02-04 1997-06-25 富士写真フイルム株式会社 メチン色素
JPH02237964A (ja) 1989-03-13 1990-09-20 Nippon Shokubai Kagaku Kogyo Co Ltd トロポロン誘導体
AU2001258829A1 (en) * 2000-05-25 2001-12-03 Nippon Shinyaku Co. Ltd. Tropolone derivatives and pharmaceutical compositions
CN1247511C (zh) * 2000-12-26 2006-03-29 财团法人乙卯研究所 环庚三烯酚酮衍生物
JP2004238291A (ja) * 2003-02-03 2004-08-26 Osaka Organic Chem Ind Ltd 白血病細胞増殖阻害剤
US20100152301A1 (en) 2005-12-01 2010-06-17 Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services Treatment of Viral Infections
JP2008158060A (ja) 2006-12-21 2008-07-10 Kyocera Mita Corp 電子写真感光体
JP5948139B2 (ja) * 2012-05-11 2016-07-06 ヒノキ新薬株式会社 サーチュイン１（ｓｉｒｔ１）遺伝子活性化剤
JP2015526396A (ja) * 2012-06-22 2015-09-10 ユニバーシティ オブ コネチカット 置換トロポロン誘導体およびその使用方法
WO2016112381A1 (en) * 2015-01-09 2016-07-14 The Board Of Trustees Of The University Of Illinois Restoring physiology in iron-deficient organisms using small molecules
WO2017156194A1 (en) 2016-03-08 2017-09-14 The Regents Of The University Of California Compositions and methods for inhibiting influenza rna polymerase pa endonuclease
US10980754B2 (en) * 2016-04-19 2021-04-20 Saint Louis University Anti-fungal compounds
AU2019252933B2 (en) 2018-04-13 2025-09-04 The Board Of Trustees Of The University Of Illinois Hinokitiol analogues, methods of preparing and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
JP2021521116A (ja) 2021-08-26
AU2019252933B2 (en) 2025-09-04
JP7503310B2 (ja) 2024-06-20
KR20210020876A (ko) 2021-02-24
EP3773900A2 (en) 2021-02-17
US20210163393A1 (en) 2021-06-03
CA3095945A1 (en) 2019-10-17
WO2019200314A2 (en) 2019-10-17
WO2019200314A3 (en) 2019-11-21
AU2025220735A1 (en) 2025-09-11
CN112672786A (zh) 2021-04-16
US12084411B2 (en) 2024-09-10
EP3773900A4 (en) 2022-03-30
KR102907811B1 (ko) 2026-01-02
AU2019252933A1 (en) 2020-11-26

Similar Documents

Publication Publication Date Title
KR102907811B1 (ko) 히노키티올 유사체, 이의 제조 방법 및 약제학적 조성물
Feng et al. New deferric amine compounds efficiently chelate excess iron to treat iron overload disorders and to prevent ferroptosis
JP7065115B2 (ja) フェロポーチン阻害剤塩
KR102017324B1 (ko) 신규한 asm 활성 직접 억제 화합물 2-아미노-2-(1,2,3-트리아졸-4-일)프로판-1,3-디올 유도체 및 이의 용도
CN101468970B (zh) 一种硝酮类化合物及其制备方法和在制药中的应用
WO2020028723A1 (en) Rbp4 antagonists for treatment and prevention of non-alcoholic fatty liver disease and gout
US9072729B2 (en) Method for treating fibrosis and cancer with imidazolium and imidazolinium compounds
Salehi et al. Synthesis, characterization and in vitro anticancer evaluations of two novel derivatives of deferasirox iron chelator
RS55714B1 (sr) Fosfaplatini i njihova primena za lečenje kancera
KR20190132622A (ko) 하이드록시벤조산 유도체, 및 그 제조방법 및 용도
EP2678339B1 (en) Methods and compositions for treating beta-thalassemia and sickle cell disease
KR102086022B1 (ko) 칼망가포디피르, 신규 화학 물질 및 기타 혼합 금속 착물, 제조방법, 조성물 및 치료방법
AU2016220153A9 (en) Therapeutic compounds
Pathan et al. Association of late transition metal complexes with ethyl 2-(2-(4-chlorophenylcarbamothioyl) hydrazono) propanoate: Design, synthesis and in vitro anticancer studies
KR102329486B1 (ko) 할로겐화 화합물 및 이의 축상 키랄성 이성질체
Zioła et al. The multifaceted mechanism of action of quinoline thiosemicarbazone based on disruption of iron homeostasis and selective IGF1R inhibition leading to oxidative stress induction
Yu et al. Rational design of copper ionophores for efficient induction of cuproptosis via simple n-alkyl modification
EP3188726B1 (en) Pharmaceutical compounds
Rouge et al. Antiproliferative effect on HepaRG cell cultures of new calix [4] arenes
EP4166137B1 (en) Therapeutic agent for fatty liver disease
CN106038551A (zh) Schiglautone A衍生物的组合物用于制备抗红细胞低下性贫血药物
AU2024325598A1 (en) Pyridazinone compound and use thereof
EP4594288A2 (en) Method of treating neurodegenerative diseases
HK40089150B (en) Therapeutic agent for fatty liver disease
JP2007191451A (ja) プロリル水酸化酵素阻害剤

Legal Events

Date Code Title Description
A16 Divisional, continuation or continuation in part application filed

Free format text: ST27 STATUS EVENT CODE: A-0-1-A10-A16-DIV-PA0104 (AS PROVIDED BY THE NATIONAL OFFICE)

PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A16-div-PA0104

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

Q12 Application published

Free format text: ST27 STATUS EVENT CODE: A-1-1-Q10-Q12-NAP-PG1501 (AS PROVIDED BY THE NATIONAL OFFICE)

E13 Pre-grant limitation requested

Free format text: ST27 STATUS EVENT CODE: A-2-3-E10-E13-LIM-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000