CN112672786A - 扁柏酚类似物、其制备方法和药物组合物 - Google Patents

扁柏酚类似物、其制备方法和药物组合物 Download PDF

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CN112672786A
CN112672786A CN201980039697.4A CN201980039697A CN112672786A CN 112672786 A CN112672786 A CN 112672786A CN 201980039697 A CN201980039697 A CN 201980039697A CN 112672786 A CN112672786 A CN 112672786A
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salt
compound
group
structural formula
following structural
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M·D·伯克
A·S·格里洛
A·G·乔飞
A·桑塔马里亚
D·布莱尔
A·布莱克
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University of Illinois System
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
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    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/717—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a seven- to twelve-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/733—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/22—Unsaturated compounds having a carboxyl group bound to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
CN201980039697.4A 2018-04-13 2019-04-12 扁柏酚类似物、其制备方法和药物组合物 Pending CN112672786A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862657127P 2018-04-13 2018-04-13
US62/657127 2018-04-13
PCT/US2019/027314 WO2019200314A2 (en) 2018-04-13 2019-04-12 Hinokitiol analogues, methods of preparing and pharmaceutical compositions thereof

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US (1) US12084411B2 (https=)
EP (1) EP3773900A4 (https=)
JP (1) JP7503310B2 (https=)
KR (2) KR20260011772A (https=)
CN (1) CN112672786A (https=)
AU (2) AU2019252933B2 (https=)
CA (1) CA3095945A1 (https=)
WO (1) WO2019200314A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114436909A (zh) * 2022-01-26 2022-05-06 河南科技大学 一种磺酰基桧木醇类衍生物及其制备方法和应用
CN115093356A (zh) * 2022-06-21 2022-09-23 广东医科大学 一种铁死亡诱导剂的制备方法与应用
CN117547525A (zh) * 2023-12-29 2024-02-13 中国科学院长春应用化学研究所 天然产物小分子桧木醇在制备治疗非酒精性脂肪性肝炎药物中的应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019252933B2 (en) 2018-04-13 2025-09-04 The Board Of Trustees Of The University Of Illinois Hinokitiol analogues, methods of preparing and pharmaceutical compositions thereof
EP4045025A4 (en) * 2019-10-16 2023-11-22 Kinesid Therapeutics, Inc. TROPOLONE DERIVATIVES AND THEIR TAUTOMERS FOR IRON REGULATION IN ANIMALS
US20230406803A1 (en) * 2019-10-16 2023-12-21 Kinesid Therapeutics, Inc Tropolone derivatives and tautomers thereof for iron regulation in animals
JP2025531628A (ja) * 2022-09-30 2025-09-22 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ 神経変性疾患の処置方法
CN120282778A (zh) * 2022-09-30 2025-07-08 伊利诺伊大学评议会 氘化扁柏酚衍生物

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US5003077A (en) * 1987-02-04 1991-03-26 Fuji Photo Film Co., Ltd. Methine dyes
CN1491197A (zh) * 2000-12-26 2004-04-21 财团法人乙卯研究所 环庚三烯酚酮衍生物
JP2013237618A (ja) * 2012-05-11 2013-11-28 Hinoki Shinyaku Kk サーチュイン１（ｓｉｒｔ１）遺伝子活性化剤
US20150166448A1 (en) * 2012-06-22 2015-06-18 University Of Connecticut Substituted Tropolone Derivatives and Methods of Use
WO2016112381A1 (en) * 2015-01-09 2016-07-14 The Board Of Trustees Of The University Of Illinois Restoring physiology in iron-deficient organisms using small molecules

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US4066784A (en) 1976-06-17 1978-01-03 Ayerst, Mckenna And Harrison Ltd. Tropone derivatives
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JP2552870B2 (ja) * 1986-08-21 1996-11-13 塩野義製薬株式会社 抗マイコプラズマ剤および抗マイコプラズマ活性を有する化合物
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US5003077A (en) * 1987-02-04 1991-03-26 Fuji Photo Film Co., Ltd. Methine dyes
CN1491197A (zh) * 2000-12-26 2004-04-21 财团法人乙卯研究所 环庚三烯酚酮衍生物
JP2013237618A (ja) * 2012-05-11 2013-11-28 Hinoki Shinyaku Kk サーチュイン１（ｓｉｒｔ１）遺伝子活性化剤
US20150166448A1 (en) * 2012-06-22 2015-06-18 University Of Connecticut Substituted Tropolone Derivatives and Methods of Use
WO2016112381A1 (en) * 2015-01-09 2016-07-14 The Board Of Trustees Of The University Of Illinois Restoring physiology in iron-deficient organisms using small molecules

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114436909A (zh) * 2022-01-26 2022-05-06 河南科技大学 一种磺酰基桧木醇类衍生物及其制备方法和应用
CN115093356A (zh) * 2022-06-21 2022-09-23 广东医科大学 一种铁死亡诱导剂的制备方法与应用
CN115093356B (zh) * 2022-06-21 2024-02-23 广东医科大学 一种铁死亡诱导剂的制备方法与应用
CN117547525A (zh) * 2023-12-29 2024-02-13 中国科学院长春应用化学研究所 天然产物小分子桧木醇在制备治疗非酒精性脂肪性肝炎药物中的应用

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JP2021521116A (ja) 2021-08-26
AU2019252933B2 (en) 2025-09-04
JP7503310B2 (ja) 2024-06-20
KR20210020876A (ko) 2021-02-24
EP3773900A2 (en) 2021-02-17
US20210163393A1 (en) 2021-06-03
CA3095945A1 (en) 2019-10-17
WO2019200314A2 (en) 2019-10-17
WO2019200314A3 (en) 2019-11-21
AU2025220735A1 (en) 2025-09-11
US12084411B2 (en) 2024-09-10
EP3773900A4 (en) 2022-03-30
KR102907811B1 (ko) 2026-01-02
AU2019252933A1 (en) 2020-11-26
KR20260011772A (ko) 2026-01-23

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