CN112601734A - 肟基萘醌类化合物及其制备方法和用途 - Google Patents

肟基萘醌类化合物及其制备方法和用途 Download PDF

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Publication number
CN112601734A
CN112601734A CN201980053982.1A CN201980053982A CN112601734A CN 112601734 A CN112601734 A CN 112601734A CN 201980053982 A CN201980053982 A CN 201980053982A CN 112601734 A CN112601734 A CN 112601734A
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amino
phenyl
alkyl
dihydronaphthalen
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CN112601734B (zh
Inventor
王恒山
经孝腾
黄日镇
贾强
褚长虎
吕玉泉
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Shanghai Ruien Shengshi Biotechnology Co.,Ltd.
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Seasons Biotechnology Taizhou Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
    • C07C251/46—Quinone oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

本申请属于药物化合物和药物技术领域，涉及肟基萘醌类化合物及其制备方法和用途，具体涉及式(I)的化合物，该化合物能够作为STAT3和IDO1的双靶点选择性抑制剂，其用于治疗卵巢癌、结肠癌及肺癌等

Description

PCT国内申请，说明书已公开。

Claims (32)

  1. PCT国内申请，权利要求书已公开。
CN201980053982.1A 2018-10-22 2019-07-11 肟基萘醌类化合物及其制备方法和用途 Active CN112601734B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201811227689.6A CN109438277A (zh) 2018-10-22 2018-10-22 肟基萘醌类化合物及其制备方法和用途
CN2018112276896 2018-10-22
PCT/CN2019/095516 WO2020082817A1 (zh) 2018-10-22 2019-07-11 肟基萘醌类化合物及其制备方法和用途

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CN112601734A true CN112601734A (zh) 2021-04-02
CN112601734B CN112601734B (zh) 2023-05-23

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WO (1) WO2020082817A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109438277A (zh) * 2018-10-22 2019-03-08 普济生物科技（台州）有限公司 肟基萘醌类化合物及其制备方法和用途
CN115124541B (zh) * 2021-03-24 2023-09-26 中国医学科学院药物研究所 一类ido1抑制剂的制备和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160130222A1 (en) * 2013-06-10 2016-05-12 The General Hospital Corporation Inhibitors of the mitf molecular pathway
CN105622658A (zh) * 2016-03-18 2016-06-01 中国药科大学 非肽类蛋白酶体抑制剂、其药物组合物、制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109438277A (zh) * 2018-10-22 2019-03-08 普济生物科技（台州）有限公司 肟基萘醌类化合物及其制备方法和用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160130222A1 (en) * 2013-06-10 2016-05-12 The General Hospital Corporation Inhibitors of the mitf molecular pathway
CN105622658A (zh) * 2016-03-18 2016-06-01 中国药科大学 非肽类蛋白酶体抑制剂、其药物组合物、制备方法和应用

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CN112601734B (zh) 2023-05-23
WO2020082817A1 (zh) 2020-04-30
CN109438277A (zh) 2019-03-08

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