KR20250159271A - 카로티노이드 조성물 및 이의 용도 - Google Patents

카로티노이드 조성물 및 이의 용도

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Publication number
KR20250159271A
KR20250159271A KR1020257035390A KR20257035390A KR20250159271A KR 20250159271 A KR20250159271 A KR 20250159271A KR 1020257035390 A KR1020257035390 A KR 1020257035390A KR 20257035390 A KR20257035390 A KR 20257035390A KR 20250159271 A KR20250159271 A KR 20250159271A
Authority
KR
South Korea
Prior art keywords
pharmaceutical composition
liposome
ionizable
disease
carotenoid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020257035390A
Other languages
English (en)
Korean (ko)
Inventor
클레트 니이키자
빅터 만들라 모요
볼린 겅
정홍 쑤
카니즈 칼리파
광성 김
Original Assignee
엘.이.에이.에프. 홀딩스 그룹 엘엘씨.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 엘.이.에이.에프. 홀딩스 그룹 엘엘씨. filed Critical 엘.이.에이.에프. 홀딩스 그룹 엘엘씨.
Publication of KR20250159271A publication Critical patent/KR20250159271A/ko
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
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    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
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Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
KR1020257035390A 2018-05-03 2019-05-03 카로티노이드 조성물 및 이의 용도 Pending KR20250159271A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862666699P 2018-05-03 2018-05-03
US62/666,699 2018-05-03
US201962809123P 2019-02-22 2019-02-22
US62/809,123 2019-02-22
PCT/US2019/030625 WO2019213538A1 (en) 2018-05-03 2019-05-03 Carotenoid compositions and uses thereof
KR1020207034818A KR102877117B1 (ko) 2018-05-03 2019-05-03 카로티노이드 조성물 및 이의 용도

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020207034818A Division KR102877117B1 (ko) 2018-05-03 2019-05-03 카로티노이드 조성물 및 이의 용도

Publications (1)

Publication Number Publication Date
KR20250159271A true KR20250159271A (ko) 2025-11-10

Family

ID=68386961

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020257035390A Pending KR20250159271A (ko) 2018-05-03 2019-05-03 카로티노이드 조성물 및 이의 용도
KR1020207034818A Active KR102877117B1 (ko) 2018-05-03 2019-05-03 카로티노이드 조성물 및 이의 용도

Family Applications After (1)

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Country Status (11)

Country Link
US (2) US12458597B2 (https=)
EP (2) EP4667017A3 (https=)
JP (3) JP7355394B2 (https=)
KR (2) KR20250159271A (https=)
CN (2) CN119185280A (https=)
AU (2) AU2019262189B2 (https=)
BR (1) BR112020022077A2 (https=)
CA (1) CA3098868A1 (https=)
ES (1) ES3063369T3 (https=)
MX (2) MX2020011662A (https=)
WO (1) WO2019213538A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180318414A1 (en) 2015-01-12 2018-11-08 Children's Medical Center Corporation Pro-Inflammatory and Adjuvant Functions of Toll-Like Receptor 4 Antagonists
CA3098868A1 (en) 2018-05-03 2019-11-07 L.E.A.F. Holdings Group Llc Carotenoid compositions and uses thereof
CA3157440A1 (en) * 2019-11-06 2021-05-14 Clet Niyikiza Carotenoid compositions and uses thereof
EP4061409A4 (en) * 2019-11-18 2023-12-27 Children's Medical Center Corporation Stimuli that hyperactivate resident dendritic cells for cancer immunotherapy
JP2023519958A (ja) * 2020-03-31 2023-05-15 ディフュージョン・ファーマシューティカルズ・エルエルシー ウイルス及び細菌誘導性呼吸器疾患の治療のための拡散増強化合物の使用
US20230134835A1 (en) * 2020-04-09 2023-05-04 L.E.A.F. Holdings Group Llc Methods of synthesizing carotenoids
WO2021207650A1 (en) * 2020-04-09 2021-10-14 L.E.A.F. Holdings Group Llc Trans-crocetin compositions and treatment regimens
WO2021207566A1 (en) * 2020-04-09 2021-10-14 L.E.A.F. Holdings Group Llc Carotenoid solutions and uses thereof
EP4132482A4 (en) * 2020-04-09 2024-05-08 L.E.A.F Holdings Group LLC TRANS-CROCETIN COMPOSITIONS AND TREATMENT SCHEMES
US20230270706A1 (en) * 2020-07-27 2023-08-31 L.E.A.F. Holdings Group Llc Trans-crocetin compositions and treatment regimens
US20230277494A1 (en) * 2020-07-27 2023-09-07 L.E.A.F. Holdings Group Llc Trans-crocetin compositions and treatment regimens
JP2023169444A (ja) * 2020-10-01 2023-11-30 株式会社Epsilon Molecular Engineering 標的タンパク質と結合し得る架橋ペプチド、当該架橋ペプチドの作製方法、及び当該架橋ペプチドを有効成分とする医薬組成物
WO2022150716A1 (en) * 2021-01-10 2022-07-14 Diffusion Pharmaceuticals Llc Methods of treating wounds and burns
WO2022240626A1 (en) * 2021-05-10 2022-11-17 L.E.A.F. Holdings Group Llc Methods and compositions for treating aging and chronic disease
WO2023029041A1 (zh) * 2021-09-06 2023-03-09 北京茵诺医药科技有限公司 靶向动脉粥样硬化脂质体纳米载体递送系统及其制备方法
CN114748461B (zh) * 2022-04-29 2023-03-21 合肥工业大学 一种藏红花酸制剂及其应用
CN114699396A (zh) * 2022-04-29 2022-07-05 合肥工业大学 藏红花酸作为抗疲劳成分在药物和食品方面的应用
US12128019B1 (en) 2023-06-15 2024-10-29 King Faisal University Nanocomposite including abscisic acid-loaded collagen nanoparticles
JP2025052190A (ja) 2023-09-25 2025-04-07 株式会社日立製作所 アンモニア合成触媒及びその製造方法
KR20250173014A (ko) 2024-05-30 2025-12-10 국립부경대학교 산학협력단 카로티노이드를 포함하는 근육 질환의 예방 및 치료용 약학 조성물
CN119081927B (zh) * 2024-08-28 2025-08-22 青岛日晟源作物营养有限公司 一株暹罗芽孢杆菌sl-k1及其菌根素提取物的制备方法和应用

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2840532A (en) * 1953-07-17 1958-06-24 Universal Oil Prod Co Alumina platinum catalyst and preparation thereof
US4699664A (en) * 1985-05-01 1987-10-13 Nestec S.A. Stabilized natural pigment complexes
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US6060511A (en) 1995-10-05 2000-05-09 Gainer; John L. Trans-sodium crocetinate, methods of making and methods of use thereof
US20030073640A1 (en) 1997-07-23 2003-04-17 Ribozyme Pharmaceuticals, Inc. Novel compositions for the delivery of negatively charged molecules
US6656498B1 (en) 1998-11-25 2003-12-02 Vanderbilt University Cationic liposomes for gene transfer
CA2437578A1 (en) 2001-02-13 2002-08-22 Rivka Cohen Carotenoid-loaded liposomes
EA200401111A1 (ru) 2002-02-25 2005-02-24 Диффьюжн Фармасьютикалз Ллс Биполярные соли транс-каротиноидов и их применение
US7759506B2 (en) * 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
WO2003101164A1 (en) 2002-05-23 2003-12-04 3M Innovative Properties Company Nanoparticle filled underfill
FR2840532B1 (fr) * 2002-06-11 2005-05-06 Ethypharm Sa Nanocapsules lipidiques furtives, procede de preparation et utilisation comme vecteur de principes(s) actif(s)
WO2003101184A2 (en) 2002-06-04 2003-12-11 California Institute Of Technology Carotenoid synthesis
EP2392562B1 (en) * 2002-07-29 2018-03-07 Cardax Pharma, Inc. Structural carotenoid analogs for the inhibition and amelioration of disease
GB0314624D0 (en) * 2003-06-23 2003-07-30 Advanced Bionutrition Europ Lt Inflammatory disease treatment
KR101017668B1 (ko) 2003-08-25 2011-02-25 디퓨젼 파마슈티컬즈 엘엘씨 양극성 트랜스 카로티노이드 염과 이들의 용도
CN1942178A (zh) * 2004-02-19 2007-04-04 奥克塞尔公司 用于治疗皮肤疾病的局部制剂
WO2006074416A1 (en) 2005-01-07 2006-07-13 Health Research Inc. 5-amino-4-imidazolecarboxamide riboside and its nucleobase as potentiators of antifolate transport and metabolism
JP5042863B2 (ja) 2005-02-14 2012-10-03 サーナ・セラピューティクス・インコーポレイテッド 生物学的に活性な分子をデリバリーするための脂質ナノ粒子系組成物および方法
US7404969B2 (en) 2005-02-14 2008-07-29 Sirna Therapeutics, Inc. Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
UA95903C2 (ru) 2005-02-24 2011-09-26 Дифьюжен Фармасьютикалз Ллк Транс-каротиноиды, их синтез, лекарственная форма и применение
CA2611137A1 (en) * 2005-03-23 2006-09-28 Cardax Pharmaceuticals, Inc. Water-dispersible carotenoids, including analogs and derivatives
AU2006251391B2 (en) * 2005-05-23 2011-10-06 Phares Pharmaceutical Research N.V. Direct dissolution
US20080221377A1 (en) 2006-06-16 2008-09-11 Lockwood Samuel F Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates
US20100015218A1 (en) 2007-02-16 2010-01-21 Vasant Jadhav Compositions and methods for potentiated activity of biologically active molecules
US20080213352A1 (en) * 2007-03-02 2008-09-04 Luna Innovations Incorporated Liposome carriers for in vivo delivery of fullerenes
JP5191764B2 (ja) * 2007-03-30 2013-05-08 理研ビタミン株式会社 睡眠改善剤
US20110224447A1 (en) 2008-08-18 2011-09-15 Bowman Keith A Novel Lipid Nanoparticles and Novel Components for Delivery of Nucleic Acids
WO2010080724A1 (en) 2009-01-12 2010-07-15 Merck Sharp & Dohme Corp. Novel lipid nanoparticles and novel components for delivery of nucleic acids
JP2009179628A (ja) 2009-01-16 2009-08-13 Tsujido Chemical Corp 養毛・育毛剤
US8569256B2 (en) 2009-07-01 2013-10-29 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
ES2613498T3 (es) 2009-07-01 2017-05-24 Protiva Biotherapeutics Inc. Nuevas formulaciones de lípidos para el suministro de agentes terapéuticos a tumores sólidos
EP2467357B1 (en) 2009-08-20 2016-03-30 Sirna Therapeutics, Inc. Novel cationic lipids with various head groups for oligonucleotide delivery
US8591555B2 (en) * 2009-08-31 2013-11-26 Warsaw Orthopedic, Inc. System with integral locking mechanism
US20120253032A1 (en) 2009-10-08 2012-10-04 Merck Sharp & Dohme Corporation Novel cationic lipids with short lipid chains for oligonucleotide delivery
US20130116419A1 (en) 2010-01-22 2013-05-09 Daniel Zewge Post-synthetic chemical modification of rna at the 2'-position of the ribose ring via "click" chemistry
CN101811956B (zh) * 2010-04-15 2013-04-17 施冬云 反式西红花酸的制备方法
US8802863B2 (en) 2010-05-24 2014-08-12 Sirna Therapeutics, Inc. Amino alcohol cationic lipids for oligonucleotide delivery
KR101891357B1 (ko) * 2010-06-02 2018-08-24 디퓨젼 파마슈티컬즈 엘엘씨 양극성 트랜스 카로티노이드의 경구용 제형
US8748667B2 (en) 2010-06-04 2014-06-10 Sirna Therapeutics, Inc. Low molecular weight cationic lipids for oligonucleotide delivery
CA2801523C (en) 2010-07-30 2021-08-03 Curevac Gmbh Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation
ES2888231T3 (es) 2010-09-20 2022-01-03 Sirna Therapeutics Inc Lípidos catiónicos de bajo peso molecular para el suministro de oligonucleótidos
EP2621480B1 (en) 2010-09-30 2018-08-15 Sirna Therapeutics, Inc. Low molecular weight cationic lipids for oligonucleotide delivery
JP2013545727A (ja) 2010-10-21 2013-12-26 メルク・シャープ・アンド・ドーム・コーポレーション オリゴヌクレオチド送達用の新規低分子量カチオン性脂質
EP2635265B1 (en) 2010-11-05 2018-04-04 Sirna Therapeutics, Inc. Novel low molecular weight cyclic amine containing cationic lipids for oligonucleotide delivery
GB201101669D0 (en) 2011-01-31 2011-03-16 Ip Science Ltd Carotenoid particles and uses thereof
EP3354644A1 (en) 2011-06-08 2018-08-01 Translate Bio, Inc. Cleavable lipids
CN103183603A (zh) 2011-12-30 2013-07-03 江苏天晟药业有限公司 藏红花酸有机胺盐及其制备方法
JP2015520194A (ja) * 2012-06-07 2015-07-16 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 薬物標的指向化のためのナノ療法
US9211298B2 (en) 2012-11-16 2015-12-15 Song Gao Compositions containing enriched natural crocin and/or crocetin, and their therapeutic or nutraceutical uses
EP3217970A4 (en) 2014-11-10 2018-07-18 Del Mar Pharmaceuticals Dianhydrogalactitol together with radiation to treat non-small-cell carcinoma of the lung and glioblastoma multiforme
FR3035589B1 (fr) 2015-04-30 2019-12-13 Biophytis Composition pour la protection des cellules de l'epithelium pigmentaire retinien
US11185523B2 (en) * 2016-03-24 2021-11-30 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer
CN105935363B (zh) * 2016-04-29 2017-03-08 暨南大学 组合物、藏红花色素类活性部位及其用途
CN107753427B (zh) 2016-08-18 2022-01-14 上海交通大学 一种全反式维甲酸脂质体制剂及其制备与应用
CA3098868A1 (en) 2018-05-03 2019-11-07 L.E.A.F. Holdings Group Llc Carotenoid compositions and uses thereof
CA3157440A1 (en) * 2019-11-06 2021-05-14 Clet Niyikiza Carotenoid compositions and uses thereof
WO2021207650A1 (en) 2020-04-09 2021-10-14 L.E.A.F. Holdings Group Llc Trans-crocetin compositions and treatment regimens
EP4132482A4 (en) 2020-04-09 2024-05-08 L.E.A.F Holdings Group LLC TRANS-CROCETIN COMPOSITIONS AND TREATMENT SCHEMES
WO2021207566A1 (en) 2020-04-09 2021-10-14 L.E.A.F. Holdings Group Llc Carotenoid solutions and uses thereof
US20230134835A1 (en) 2020-04-09 2023-05-04 L.E.A.F. Holdings Group Llc Methods of synthesizing carotenoids
US20230277494A1 (en) 2020-07-27 2023-09-07 L.E.A.F. Holdings Group Llc Trans-crocetin compositions and treatment regimens
US20230270706A1 (en) 2020-07-27 2023-08-31 L.E.A.F. Holdings Group Llc Trans-crocetin compositions and treatment regimens

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