KR20250111141A - 단백질의 제조 방법 - Google Patents

단백질의 제조 방법

Info

Publication number
KR20250111141A
KR20250111141A KR1020257019602A KR20257019602A KR20250111141A KR 20250111141 A KR20250111141 A KR 20250111141A KR 1020257019602 A KR1020257019602 A KR 1020257019602A KR 20257019602 A KR20257019602 A KR 20257019602A KR 20250111141 A KR20250111141 A KR 20250111141A
Authority
KR
South Korea
Prior art keywords
antigen
amino acid
region
binding domain
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020257019602A
Other languages
English (en)
Korean (ko)
Inventor
카테리나 파루크시나
라이지 가와데
쇼헤이 고바야시
준이치 나카야마
다카히로 노나카
Original Assignee
추가이 세이야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 추가이 세이야쿠 가부시키가이샤 filed Critical 추가이 세이야쿠 가부시키가이샤
Publication of KR20250111141A publication Critical patent/KR20250111141A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020257019602A 2022-11-25 2023-11-24 단백질의 제조 방법 Pending KR20250111141A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022187883 2022-11-25
JPJP-P-2022-187883 2022-11-25
PCT/JP2023/042131 WO2024111657A1 (ja) 2022-11-25 2023-11-24 タンパク質の製造方法

Publications (1)

Publication Number Publication Date
KR20250111141A true KR20250111141A (ko) 2025-07-22

Family

ID=91196134

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020257019602A Pending KR20250111141A (ko) 2022-11-25 2023-11-24 단백질의 제조 방법

Country Status (10)

Country Link
EP (1) EP4624489A1 (https=)
JP (1) JPWO2024111657A1 (https=)
KR (1) KR20250111141A (https=)
CN (1) CN120265651A (https=)
AR (1) AR131163A1 (https=)
AU (1) AU2023387113A1 (https=)
IL (1) IL320881A (https=)
MX (1) MX2025005439A (https=)
TW (1) TW202436348A (https=)
WO (2) WO2024111657A1 (https=)

Citations (6)

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WO2006047340A2 (en) 2004-10-22 2006-05-04 Amgen Inc. Methods for refolding of recombinant antibodies
WO2020027330A1 (ja) 2018-08-03 2020-02-06 中外製薬株式会社 互いに連結された２つの抗原結合ドメインを含む抗原結合分子
WO2020037016A1 (en) 2018-08-15 2020-02-20 Bristol-Myers Squibb Company Protein fragmentation control strategy by re-oxidation in downstream chromatography
WO2021157679A1 (en) 2020-02-05 2021-08-12 Chugai Seiyaku Kabushiki Kaisha Methods for producing and/or enriching recombinant antigen-binding molecules
WO2021201087A1 (en) 2020-03-31 2021-10-07 Chugai Seiyaku Kabushiki Kaisha Method for producing multispecific antigen-binding molecules
WO2021200898A1 (en) 2020-03-31 2021-10-07 Chugai Seiyaku Kabushiki Kaisha Dll3-targeting multispecific antigen-binding molecules and uses thereof

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Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
WO2006047340A2 (en) 2004-10-22 2006-05-04 Amgen Inc. Methods for refolding of recombinant antibodies
WO2020027330A1 (ja) 2018-08-03 2020-02-06 中外製薬株式会社 互いに連結された２つの抗原結合ドメインを含む抗原結合分子
WO2020037016A1 (en) 2018-08-15 2020-02-20 Bristol-Myers Squibb Company Protein fragmentation control strategy by re-oxidation in downstream chromatography
WO2021157679A1 (en) 2020-02-05 2021-08-12 Chugai Seiyaku Kabushiki Kaisha Methods for producing and/or enriching recombinant antigen-binding molecules
WO2021201087A1 (en) 2020-03-31 2021-10-07 Chugai Seiyaku Kabushiki Kaisha Method for producing multispecific antigen-binding molecules
WO2021200898A1 (en) 2020-03-31 2021-10-07 Chugai Seiyaku Kabushiki Kaisha Dll3-targeting multispecific antigen-binding molecules and uses thereof

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Also Published As

Publication number Publication date
IL320881A (en) 2025-07-01
AR131163A1 (es) 2025-02-19
TW202436348A (zh) 2024-09-16
JPWO2024111657A1 (https=) 2024-05-30
MX2025005439A (es) 2025-06-02
WO2024111657A1 (ja) 2024-05-30
EP4624489A1 (en) 2025-10-01
WO2025109783A1 (ja) 2025-05-30
CN120265651A (zh) 2025-07-04
AU2023387113A1 (en) 2025-05-15

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