KR20250005991A - Eva1 단백질에 결합하는 인간화 항체 또는 이의 기능적 단편, 항체-약물 복합체 및 키메라 항원 수용체 - Google Patents

Eva1 단백질에 결합하는 인간화 항체 또는 이의 기능적 단편, 항체-약물 복합체 및 키메라 항원 수용체 Download PDF

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KR20250005991A
KR20250005991A KR1020247031784A KR20247031784A KR20250005991A KR 20250005991 A KR20250005991 A KR 20250005991A KR 1020247031784 A KR1020247031784 A KR 1020247031784A KR 20247031784 A KR20247031784 A KR 20247031784A KR 20250005991 A KR20250005991 A KR 20250005991A
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South Korea
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amino acid
acid sequence
antibody
seq
set forth
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Pending
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KR1020247031784A
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Korean (ko)
Inventor
마사히로 미치시타
토루 곤도
세이타로 테라쿠라
마사히데 오사키
히토시 키요이
Original Assignee
가부시키가이샤 큐어드
국립대학법인 홋가이도 다이가쿠
고쿠리츠 다이가쿠 호우징 도우카이 고쿠리츠 다이가쿠 기코우
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Publication of KR20250005991A publication Critical patent/KR20250005991A/ko
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K—PEPTIDES
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2319/00—Fusion polypeptide
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KR1020247031784A 2022-03-09 2022-09-28 Eva1 단백질에 결합하는 인간화 항체 또는 이의 기능적 단편, 항체-약물 복합체 및 키메라 항원 수용체 Pending KR20250005991A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2022-036463 2022-03-09
JP2022036463 2022-03-09
PCT/JP2022/036260 WO2023171009A1 (ja) 2022-03-09 2022-09-28 Ｅｖａ１タンパク質に結合する、ヒト化抗体又はその機能的断片、抗体薬物複合体及びキメラ抗原受容体

Publications (1)

Publication Number Publication Date
KR20250005991A true KR20250005991A (ko) 2025-01-10

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ID=87936484

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Application Number Title Priority Date Filing Date
KR1020247031784A Pending KR20250005991A (ko) 2022-03-09 2022-09-28 Eva1 단백질에 결합하는 인간화 항체 또는 이의 기능적 단편, 항체-약물 복합체 및 키메라 항원 수용체

Country Status (6)

Country Link
US (1) US20250186602A1 (https=)
EP (1) EP4491729A4 (https=)
JP (1) JPWO2023171009A1 (https=)
KR (1) KR20250005991A (https=)
CN (1) CN119213128A (https=)
WO (1) WO2023171009A1 (https=)

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WO2012043747A1 (ja) 2010-09-30 2012-04-05 独立行政法人理化学研究所 グリオーマの治療方法、グリオーマの検査方法、所望の物質をグリオーマに送達させる方法、及びそれらの方法に用いられる薬剤
KR20170022668A (ko) 2015-08-21 2017-03-02 대우조선해양 주식회사 코어 샘플 채취 시스템 및 방법

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