KR20250004733A - 그렘린-1 길항제와 ras-raf-mek-erk 신호전달 억제제의 조합 - Google Patents

그렘린-1 길항제와 ras-raf-mek-erk 신호전달 억제제의 조합 Download PDF

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KR20250004733A
KR20250004733A KR1020247037223A KR20247037223A KR20250004733A KR 20250004733 A KR20250004733 A KR 20250004733A KR 1020247037223 A KR1020247037223 A KR 1020247037223A KR 20247037223 A KR20247037223 A KR 20247037223A KR 20250004733 A KR20250004733 A KR 20250004733A
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cancer
mek
grem1
inhibitor
raf
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Korean (ko)
Inventor
가레스 찰스 글린드워 데이비스
폴 존스
데 산데 브람 제로엔 반
제니퍼 패트리샤 모턴
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유씨비 바이오파마 에스알엘
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Publication of KR20250004733A publication Critical patent/KR20250004733A/ko
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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KR1020247037223A 2022-04-08 2023-04-06 그렘린-1 길항제와 ras-raf-mek-erk 신호전달 억제제의 조합 Pending KR20250004733A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2205203.9 2022-04-08
GBGB2205203.9A GB202205203D0 (en) 2022-04-08 2022-04-08 Combination with inhibitor
PCT/EP2023/059270 WO2023194583A1 (en) 2022-04-08 2023-04-06 Combination of a gremlin-1 antagonist with an inhibitor of ras-raf-mek-erk signalling

Publications (1)

Publication Number Publication Date
KR20250004733A true KR20250004733A (ko) 2025-01-08

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KR1020247037223A Pending KR20250004733A (ko) 2022-04-08 2023-04-06 그렘린-1 길항제와 ras-raf-mek-erk 신호전달 억제제의 조합

Country Status (11)

Country Link
US (1) US20250228826A1 (https=)
EP (1) EP4504777A1 (https=)
JP (1) JP2025513807A (https=)
KR (1) KR20250004733A (https=)
CN (1) CN119790069A (https=)
AU (1) AU2023248696A1 (https=)
CA (1) CA3255427A1 (https=)
GB (1) GB202205203D0 (https=)
IL (1) IL315760A (https=)
MX (1) MX2024012313A (https=)
WO (1) WO2023194583A1 (https=)

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Publication number Priority date Publication date Assignee Title
WO2025090966A1 (en) * 2023-10-26 2025-05-01 Vevo Therapeutics, Inc. Mek inhibitors, alone or in combination with cdk4/5 inhibitors, for use in treating cancer
WO2026027660A1 (en) 2024-08-02 2026-02-05 UCB Biopharma SRL Formulations of anti-gremlin-1 antibodies

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