MX2024012313A - Combinación de un antagonista de gremlin-1 con un inhibidor de la señalización de ras-raf-mek-erk. - Google Patents

Combinación de un antagonista de gremlin-1 con un inhibidor de la señalización de ras-raf-mek-erk.

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Publication number
MX2024012313A
MX2024012313A MX2024012313A MX2024012313A MX2024012313A MX 2024012313 A MX2024012313 A MX 2024012313A MX 2024012313 A MX2024012313 A MX 2024012313A MX 2024012313 A MX2024012313 A MX 2024012313A MX 2024012313 A MX2024012313 A MX 2024012313A
Authority
MX
Mexico
Prior art keywords
raf
mek
ras
combination
antagonist
Prior art date
Application number
MX2024012313A
Other languages
English (en)
Spanish (es)
Inventor
Gareth Charles Glyndwr Davies
Paul Jones
De Sande Bram Jeroen Van
Jennifer Patricia Morton
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of MX2024012313A publication Critical patent/MX2024012313A/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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MX2024012313A 2022-04-08 2024-10-03 Combinación de un antagonista de gremlin-1 con un inhibidor de la señalización de ras-raf-mek-erk. MX2024012313A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB2205203.9A GB202205203D0 (en) 2022-04-08 2022-04-08 Combination with inhibitor
PCT/EP2023/059270 WO2023194583A1 (en) 2022-04-08 2023-04-06 Combination of a gremlin-1 antagonist with an inhibitor of ras-raf-mek-erk signalling

Publications (1)

Publication Number Publication Date
MX2024012313A true MX2024012313A (es) 2024-11-08

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ID=81653346

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MX2024012313A MX2024012313A (es) 2022-04-08 2024-10-03 Combinación de un antagonista de gremlin-1 con un inhibidor de la señalización de ras-raf-mek-erk.

Country Status (11)

Country Link
US (1) US20250228826A1 (https=)
EP (1) EP4504777A1 (https=)
JP (1) JP2025513807A (https=)
KR (1) KR20250004733A (https=)
CN (1) CN119790069A (https=)
AU (1) AU2023248696A1 (https=)
CA (1) CA3255427A1 (https=)
GB (1) GB202205203D0 (https=)
IL (1) IL315760A (https=)
MX (1) MX2024012313A (https=)
WO (1) WO2023194583A1 (https=)

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Publication number Priority date Publication date Assignee Title
WO2025090966A1 (en) * 2023-10-26 2025-05-01 Vevo Therapeutics, Inc. Mek inhibitors, alone or in combination with cdk4/5 inhibitors, for use in treating cancer
WO2026027660A1 (en) 2024-08-02 2026-02-05 UCB Biopharma SRL Formulations of anti-gremlin-1 antibodies

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