AU2023248696A1 - Combination of a gremlin-1 antagonist with an inhibitor of ras-raf-mek-erk signalling - Google Patents

Combination of a gremlin-1 antagonist with an inhibitor of ras-raf-mek-erk signalling Download PDF

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Publication number
AU2023248696A1
AU2023248696A1 AU2023248696A AU2023248696A AU2023248696A1 AU 2023248696 A1 AU2023248696 A1 AU 2023248696A1 AU 2023248696 A AU2023248696 A AU 2023248696A AU 2023248696 A AU2023248696 A AU 2023248696A AU 2023248696 A1 AU2023248696 A1 AU 2023248696A1
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Prior art keywords
cancer
mek
antagonist
inhibitor
raf
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AU2023248696A
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Inventor
Gareth Charles Glyndwr DAVIES
Paul Jones
Jennifer Patricia MORTON
Bram Jeroen VAN DE SANDE
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UCB Biopharma SRL
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UCB Biopharma SRL
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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AU2023248696A 2022-04-08 2023-04-06 Combination of a gremlin-1 antagonist with an inhibitor of ras-raf-mek-erk signalling Pending AU2023248696A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2205203.9 2022-04-08
GBGB2205203.9A GB202205203D0 (en) 2022-04-08 2022-04-08 Combination with inhibitor
PCT/EP2023/059270 WO2023194583A1 (en) 2022-04-08 2023-04-06 Combination of a gremlin-1 antagonist with an inhibitor of ras-raf-mek-erk signalling

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AU2023248696A1 true AU2023248696A1 (en) 2024-10-10

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AU2023248696A Pending AU2023248696A1 (en) 2022-04-08 2023-04-06 Combination of a gremlin-1 antagonist with an inhibitor of ras-raf-mek-erk signalling

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US (1) US20250228826A1 (https=)
EP (1) EP4504777A1 (https=)
JP (1) JP2025513807A (https=)
KR (1) KR20250004733A (https=)
CN (1) CN119790069A (https=)
AU (1) AU2023248696A1 (https=)
CA (1) CA3255427A1 (https=)
GB (1) GB202205203D0 (https=)
IL (1) IL315760A (https=)
MX (1) MX2024012313A (https=)
WO (1) WO2023194583A1 (https=)

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Publication number Priority date Publication date Assignee Title
WO2025090966A1 (en) * 2023-10-26 2025-05-01 Vevo Therapeutics, Inc. Mek inhibitors, alone or in combination with cdk4/5 inhibitors, for use in treating cancer
WO2026027660A1 (en) 2024-08-02 2026-02-05 UCB Biopharma SRL Formulations of anti-gremlin-1 antibodies

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JP2025513807A (ja) 2025-04-30
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