KR20240168982A - 항-메소텔린 car을 발현하는 세포 - Google Patents

항-메소텔린 car을 발현하는 세포 Download PDF

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KR20240168982A
KR20240168982A KR1020247032909A KR20247032909A KR20240168982A KR 20240168982 A KR20240168982 A KR 20240168982A KR 1020247032909 A KR1020247032909 A KR 1020247032909A KR 20247032909 A KR20247032909 A KR 20247032909A KR 20240168982 A KR20240168982 A KR 20240168982A
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amino acid
acid sequence
seq
set forth
sequence set
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이스트반 코바크스
앙드레 곤살로 도 에스피리투 산투 시모에스
샘 일링워스
올리버 누스바우머
사라 에드워즈
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감마델타 테라퓨틱스 엘티디
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A61K39/4611—
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    • A61K39/4637—
    • A61K39/464468—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4254—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • A61K40/4255—Mesothelin [MSLN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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  • Immunology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020247032909A 2022-04-04 2023-04-04 항-메소텔린 car을 발현하는 세포 Pending KR20240168982A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB2204927.4 2022-04-04
GBGB2204927.4A GB202204927D0 (en) 2022-04-04 2022-04-04 Cells expressing mesothelin
US202363482752P 2023-02-01 2023-02-01
US63/482,752 2023-02-01
PCT/IB2023/053431 WO2023194911A1 (en) 2022-04-04 2023-04-04 Cells expressing an anti-mesothelin car

Publications (1)

Publication Number Publication Date
KR20240168982A true KR20240168982A (ko) 2024-12-02

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KR1020247032909A Pending KR20240168982A (ko) 2022-04-04 2023-04-04 항-메소텔린 car을 발현하는 세포

Country Status (14)

Country Link
US (1) US20250025555A1 (https=)
EP (2) EP4628504A3 (https=)
JP (1) JP2025511409A (https=)
KR (1) KR20240168982A (https=)
CN (1) CN119110845A (https=)
AU (1) AU2023250251A1 (https=)
CA (1) CA3254719A1 (https=)
CL (2) CL2024002948A1 (https=)
CO (1) CO2024013343A2 (https=)
IL (1) IL315660A (https=)
MX (1) MX2024012314A (https=)
PE (1) PE20242282A1 (https=)
TW (1) TW202405164A (https=)
WO (1) WO2023194911A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4504247A1 (en) 2022-04-04 2025-02-12 Gammadelta Therapeutics Ltd Novel gene armoring
WO2025240496A1 (en) * 2024-05-14 2025-11-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Natural killer cells expressing a mesothelin-targeted chimeric antigen receptor and interleukin-15 for the treatment of solid tumors
WO2026069206A1 (en) * 2024-09-25 2026-04-02 Takeda Pharmaceutical Company Limited Hypoimmunogenic modified gamma delta t cells

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
EP1777294A1 (en) 2005-10-20 2007-04-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
US9272002B2 (en) * 2011-10-28 2016-03-01 The Trustees Of The University Of Pennsylvania Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
EP3783098A1 (en) * 2013-05-14 2021-02-24 Board Of Regents, The University Of Texas System Human application of engineered chimeric antigen receptor (car) t-cells
US20200399383A1 (en) * 2018-02-13 2020-12-24 Novartis Ag Chimeric antigen receptor therapy in combination with il-15r and il15
TW202020145A (zh) * 2018-07-13 2020-06-01 國立大學法人京都大學 γδＴ細胞的製造方法
WO2020172555A1 (en) * 2019-02-21 2020-08-27 Regents Of The University Of Minnesota Genetically modified gamma delta t cells and methods of making and using
US20230159892A1 (en) * 2020-04-06 2023-05-25 Synthekine, Inc. Engineered immune cells
US20230226181A1 (en) * 2020-06-22 2023-07-20 Nanjing Legend Biotech Co., Ltd. GENETIC ENGINEERING OF gamma delta T CELLS FOR IMMUNOTHERAPY
JP7138989B1 (ja) * 2020-08-04 2022-09-20 セレンジーン インコーポレイテッド メソテリンに特異的に結合する抗メソテリンキメラ抗原受容体
JP2023540339A (ja) * 2020-09-04 2023-09-22 インパクト バイオ ユーエスエー インコーポレイテッド 癌治療に使用するためのバイシストロン性阻害性キメラ抗原受容体（ｉＣＡＲ）／活性化キメラ抗原受容体（ａＣＡＲ）構築物
GB202013962D0 (en) * 2020-09-04 2020-10-21 Gammadelta Therapeutics Ltd Immunotherapy composition

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EP4628504A2 (en) 2025-10-08
CL2025002218A1 (es) 2025-11-14
WO2023194911A1 (en) 2023-10-12
JP2025511409A (ja) 2025-04-15
CO2024013343A2 (es) 2024-10-10
IL315660A (en) 2024-11-01
TW202405164A (zh) 2024-02-01
PE20242282A1 (es) 2024-12-02
AU2023250251A1 (en) 2024-10-03
CL2024002948A1 (es) 2025-02-14
EP4504344A1 (en) 2025-02-12
EP4628504A3 (en) 2025-12-10
CN119110845A (zh) 2024-12-10
US20250025555A1 (en) 2025-01-23
CA3254719A1 (en) 2023-10-12
MX2024012314A (es) 2024-11-08

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