KR20240168912A - 순환 종양 세포 분리 키트, 순환 종양 세포 분리 용기 및 순환 종양 세포의 분리 방법 - Google Patents

순환 종양 세포 분리 키트, 순환 종양 세포 분리 용기 및 순환 종양 세포의 분리 방법 Download PDF

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KR20240168912A
KR20240168912A KR1020247015275A KR20247015275A KR20240168912A KR 20240168912 A KR20240168912 A KR 20240168912A KR 1020247015275 A KR1020247015275 A KR 1020247015275A KR 20247015275 A KR20247015275 A KR 20247015275A KR 20240168912 A KR20240168912 A KR 20240168912A
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circulating tumor
cell separation
blood
aqueous solution
tumor cell
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Korean (ko)
Inventor
다카야 우치야마
마리카 간다
구니야 고마이
도모노리 이노우에
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세키스이 메디칼 가부시키가이샤
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Publication of KR20240168912A publication Critical patent/KR20240168912A/ko
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C12N5/0694—Cells of blood, e.g. leukemia cells, myeloma cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/10—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by centrifugation ; Cyclones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02—Separating microorganisms from their culture media
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Sustainable Development (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020247015275A 2022-03-25 2022-10-17 순환 종양 세포 분리 키트, 순환 종양 세포 분리 용기 및 순환 종양 세포의 분리 방법 Pending KR20240168912A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022049652 2022-03-25
JPJP-P-2022-049652 2022-03-25
PCT/JP2022/038554 WO2023181468A1 (ja) 2022-03-25 2022-10-17 循環腫瘍細胞分離キット、循環腫瘍細胞分離容器及び循環腫瘍細胞の分離方法

Publications (1)

Publication Number Publication Date
KR20240168912A true KR20240168912A (ko) 2024-12-02

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KR1020247015275A Pending KR20240168912A (ko) 2022-03-25 2022-10-17 순환 종양 세포 분리 키트, 순환 종양 세포 분리 용기 및 순환 종양 세포의 분리 방법

Country Status (6)

Country Link
US (1) US20250197810A1 (https=)
EP (1) EP4502599A1 (https=)
JP (1) JP7355473B1 (https=)
KR (1) KR20240168912A (https=)
CN (1) CN118284808A (https=)
WO (1) WO2023181468A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7586593B2 (ja) * 2022-09-29 2024-11-19 積水メディカル株式会社 血液保存用組成物及び血液採取容器

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021500585A (ja) 2017-10-19 2021-01-07 ストレック， インコーポレイテッド 溶血、凝固調節および細胞外小胞の安定化のための組成物

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JPH01199158A (ja) * 1987-10-20 1989-08-10 Seitetsu Kagaku Co Ltd 赤血球保存液
WO2003019141A2 (en) * 2001-08-23 2003-03-06 Immunivest Corporation Analysis of circulating tumor cells, fragments, and debris
JP2007271388A (ja) * 2006-03-30 2007-10-18 Hidetoshi Tsuchida 血清または血漿の分離方法および血液分離管
PL3006109T3 (pl) 2009-05-15 2019-12-31 Becton, Dickinson And Company Urządzenie do rozdzielania faz gęstości
SG10201605495UA (en) * 2011-07-05 2016-09-29 Becton Dickinson Co Coagulation controlling agents and devices comprising the same
BR112014018970A8 (pt) * 2012-02-02 2017-07-11 Becton Dickinson Co Dispositivos de coleta de amostra com agentes de estabilização sanguínea
US20150148212A1 (en) * 2012-05-10 2015-05-28 Konica Minolta, Inc. Process for removing red blood cells and centrifugal tube for blood collection
WO2015046557A1 (ja) * 2013-09-30 2015-04-02 積水メディカル株式会社 循環腫瘍細胞濃縮分離デバイス及び循環腫瘍細胞の濃縮分離方法
DE112017007639T5 (de) * 2017-06-13 2020-06-04 Chung Chin SUN Neues verfahren zum blutplasmaprotein-aktivitätserhalt
JP7036670B2 (ja) * 2018-05-31 2022-03-15 アークレイ株式会社 血液中の稀少細胞検査、該検査ための血液処理方法及び採血管
CN114340493B (zh) * 2019-12-05 2025-12-23 积水医疗株式会社 血液采集容器和血浆的分离方法
US20230090675A1 (en) * 2020-03-11 2023-03-23 Sekisui Medical Co., Ltd. Leukocyte concentration separation device, blood collection container, and method for separating leukocytes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021500585A (ja) 2017-10-19 2021-01-07 ストレック， インコーポレイテッド 溶血、凝固調節および細胞外小胞の安定化のための組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Zeina Habli, Walid AlChamaa, Raya Saab, Humam Kadara and Massoud L. Khraiche. Circulating Tumor Cell Detection Technologies and Clinical Utility: Challenges and Opportunities. Cancers 2020, 12, 1930; doi: 10.3390/cancers12071930

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Publication number Publication date
CN118284808A (zh) 2024-07-02
EP4502599A1 (en) 2025-02-05
JP7355473B1 (ja) 2023-10-03
WO2023181468A1 (ja) 2023-09-28
US20250197810A1 (en) 2025-06-19
JPWO2023181468A1 (https=) 2023-09-28

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Patent event date: 20240508

Patent event code: PA01051R01D

Comment text: International Patent Application

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