KR20240168375A - 고순도 화합물의 제조 방법 및 정제 방법 - Google Patents

고순도 화합물의 제조 방법 및 정제 방법 Download PDF

Info

Publication number
KR20240168375A
KR20240168375A KR1020247035203A KR20247035203A KR20240168375A KR 20240168375 A KR20240168375 A KR 20240168375A KR 1020247035203 A KR1020247035203 A KR 1020247035203A KR 20247035203 A KR20247035203 A KR 20247035203A KR 20240168375 A KR20240168375 A KR 20240168375A
Authority
KR
South Korea
Prior art keywords
pyrido
dihydro
benzodiazepin
salt
diethylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247035203A
Other languages
English (en)
Korean (ko)
Inventor
아츠시 오노
다카히로 혼다
Original Assignee
산텐 세이야꾸 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 산텐 세이야꾸 가부시키가이샤 filed Critical 산텐 세이야꾸 가부시키가이샤
Publication of KR20240168375A publication Critical patent/KR20240168375A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020247035203A 2022-03-30 2023-03-29 고순도 화합물의 제조 방법 및 정제 방법 Pending KR20240168375A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2022-056754 2022-03-30
JP2022056754 2022-03-30
PCT/JP2023/012761 WO2023190663A1 (ja) 2022-03-30 2023-03-29 高純度化合物の製造方法および精製方法

Publications (1)

Publication Number Publication Date
KR20240168375A true KR20240168375A (ko) 2024-11-29

Family

ID=88202044

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247035203A Pending KR20240168375A (ko) 2022-03-30 2023-03-29 고순도 화합물의 제조 방법 및 정제 방법

Country Status (7)

Country Link
US (1) US20250214992A1 (https=)
EP (1) EP4506347A4 (https=)
JP (1) JPWO2023190663A1 (https=)
KR (1) KR20240168375A (https=)
CN (1) CN118946564A (https=)
TW (1) TW202402753A (https=)
WO (1) WO2023190663A1 (https=)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60215683A (ja) 1984-03-14 1985-10-29 ドクトル．カール　トーメー　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング 新規縮合ジアゼピノン
JPH09318772A (ja) 1996-05-28 1997-12-12 Rhythm Watch Co Ltd 装飾装置
JP2022030489A (ja) 2020-08-07 2022-02-18 株式会社ユニバーサルエンターテインメント 遊技機

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3626095A1 (de) * 1986-07-31 1988-02-11 Thomae Gmbh Dr K Neue substituierte pyrido(2,3-b)(1,4)benzodiazepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5716952A (en) 1992-03-18 1998-02-10 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of muscarinic antagonists
JP2017535545A (ja) * 2014-11-21 2017-11-30 ラボラトリオス・デル・デエレ・エステベ・エセ・ア 疼痛に対する多様な活性を有するスピロ−イソキノリン−１，４’−ピペリジン化合物
CN114302726A (zh) 2020-08-04 2022-04-08 参天制药株式会社 用于治疗近视、预防近视及/或抑制近视发展的药剂
WO2022080397A1 (ja) * 2020-10-14 2022-04-21 参天製薬株式会社 安定な医薬組成物
EP4501329A4 (en) * 2022-03-30 2026-03-25 Santen Pharmaceutical Co Ltd METHOD FOR STERILIZING AND PACKAGING A PHARMACEUTICAL PREPARATION

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60215683A (ja) 1984-03-14 1985-10-29 ドクトル．カール　トーメー　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング 新規縮合ジアゼピノン
JPH09318772A (ja) 1996-05-28 1997-12-12 Rhythm Watch Co Ltd 装飾装置
JP2022030489A (ja) 2020-08-07 2022-02-18 株式会社ユニバーサルエンターテインメント 遊技機

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
비특허문헌 1: Wolfnard W. Engel et al., J. Med. Chem., 1989, 32(8), 1718-1724

Also Published As

Publication number Publication date
EP4506347A4 (en) 2026-03-25
WO2023190663A1 (ja) 2023-10-05
US20250214992A1 (en) 2025-07-03
CN118946564A (zh) 2024-11-12
TW202402753A (zh) 2024-01-16
JPWO2023190663A1 (https=) 2023-10-05
EP4506347A1 (en) 2025-02-12

Similar Documents

Publication Publication Date Title
JP2024540080A (ja) Ｉｒａｋ４分解剤およびその合成
KR102442536B1 (ko) 리나글립틴 결정형 및 이의 제조방법
EP2778159B1 (en) 7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal
US20080085903A1 (en) Novel crystalline forms of aripiprazole
SG174982A1 (en) L-ornithine phenyl acetate and methods of making thereof
EP3433233B1 (en) Novel crystalline form of 1-(5-(2,4-difluorophenyl)-1-((3- fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n- methylmethanamine salt
EP3022209B1 (en) Dolutegravir potassium salt
EP3205653A1 (en) Crystal form of bisulfate of jak inhibitor and preparation method therefor
AU2022283638B2 (en) Co-crystal forms of a novobiocin analog and proline
EP0579681A1 (en) Crystalline tiagabine hydrochloride monohydrate, its preparation and use
KR101246392B1 (ko) 술폰아미드 화합물 및 그 결정
RU2719484C2 (ru) Натриевая соль ингибитора транспортера мочевой кислоты и его кристаллическая форма
NO330528B1 (no) Nye salter av benzazepinforbindelser, fremgangsmater for fremstilling derav, og anvendelse av slike i farmasoytiske sammensetninger
CN117377658A (zh) 喹啉衍生物化合物的制备方法
EP2896623A1 (en) CRYSTAL OF N-[2-({2-[(2S)-2-CYANOPYRROLIDIN-1-YL]-2- OXOETHYL}AMINO)-2-METHYLPROPYL]-2-METHYLPYRAZOLO[1,5-a]PYRIMIDINE-6-CARBOXAMIDE
RU2228931C2 (ru) Кристаллические формы 3-(2,4-дихлорбензил)-2-метил-n-(пентилсульфонил)-3h- бензимидазол-5-карбоксамида
KR20240168375A (ko) 고순도 화합물의 제조 방법 및 정제 방법
JP2023536911A (ja) Ｏ－糖タンパク質－２－アセトアミド－２－デオキシ－３－ｄ－グルコピラノシダーゼ阻害剤の結晶形態
CN111004255A (zh) 一种头孢卡品内酯化合物或其盐酸盐的制备方法
CA3076557A1 (en) Crystalline form of alkynyl pyridine prolyl hydroxylase inhibitor and method for preparing same
US10174001B2 (en) Crystals of 5-cyclopropyl-2-((1-(3-fluorobenzyl)-1H-indol-5-yl)amino)nicotinic acid
WO2020016827A1 (en) Purified crystalline detomidine hydrochloride monohydrate, anhydrate and free base with low amounts of iso-detomidine and other impurities by recrystallisation in water
EP4596541A1 (en) Novel crystalline form of enavogliflozin, and preparation method therefor
DE60303603T2 (de) Benzolsulfonatsalz eines morpholinharnstoff-derivats zur verwendung als ccr-3 antagonist bei der behandlung von entzündlichen erkrankungen
WO2026018176A1 (en) 2-(4-chloro-2 methoxyphenyl)-2-((3-methoxy-5-(methylsulfonyl)phenyl)amino)-1-(5-(trifluoro¬methoxy)-1h-indol-3-yl)ethanone and pharmaceutical compositions comprising the same

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20241022

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application