KR20240167631A - 환원형 β-니코틴아미드 모노뉴클레오티드 이나트륨염의 다결정형 및 이의 제조 방법과 용도 - Google Patents

환원형 β-니코틴아미드 모노뉴클레오티드 이나트륨염의 다결정형 및 이의 제조 방법과 용도 Download PDF

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KR20240167631A
KR20240167631A KR1020247028723A KR20247028723A KR20240167631A KR 20240167631 A KR20240167631 A KR 20240167631A KR 1020247028723 A KR1020247028723 A KR 1020247028723A KR 20247028723 A KR20247028723 A KR 20247028723A KR 20240167631 A KR20240167631 A KR 20240167631A
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crystal
crystalline form
disodium salt
pattern
reduced
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Inventor
싱 가오
지안준 유
치앙 센
친유안 수
인샨 리
지아링 리우
리우레이 창
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에페팜 (상하이) 컴퍼니 리미티드
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
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    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/13—Nucleic acids or derivatives thereof
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
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KR1020247028723A 2022-02-23 2023-02-09 환원형 β-니코틴아미드 모노뉴클레오티드 이나트륨염의 다결정형 및 이의 제조 방법과 용도 Pending KR20240167631A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202210168280.1 2022-02-23
CN202210168280.1A CN115368423B (zh) 2022-02-23 2022-02-23 还原型β-烟酰胺单核苷酸二钠盐的多晶型及其制法和用途
PCT/CN2023/075226 WO2023160405A1 (zh) 2022-02-23 2023-02-09 还原型β‐烟酰胺单核苷酸二钠盐的多晶型及其制法和用途

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KR20240167631A true KR20240167631A (ko) 2024-11-27

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KR1020247028723A Pending KR20240167631A (ko) 2022-02-23 2023-02-09 환원형 β-니코틴아미드 모노뉴클레오티드 이나트륨염의 다결정형 및 이의 제조 방법과 용도

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Country Link
US (1) US12570683B2 (https=)
EP (1) EP4484438A1 (https=)
JP (1) JP7762933B2 (https=)
KR (1) KR20240167631A (https=)
CN (2) CN115368423B (https=)
AU (1) AU2023223327B2 (https=)
CA (1) CA3244879A1 (https=)
NZ (1) NZ813980A (https=)
WO (1) WO2023160405A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115368423B (zh) 2022-02-23 2025-05-09 音芙医药科技(上海)有限公司 还原型β-烟酰胺单核苷酸二钠盐的多晶型及其制法和用途
WO2023179793A1 (zh) * 2022-03-25 2023-09-28 成都嘉葆药银医药科技有限公司 一种1H-吡咯并[2,3-c]吡啶类化合物的晶型及其制备方法
CN119320416B (zh) * 2023-11-10 2026-01-06 音芙医药科技(上海)有限公司 还原型β-烟酰胺单核苷酸钙盐的多晶型及其制法和用途
CN119978042B (zh) * 2023-11-10 2025-09-09 音芙医药科技(上海)有限公司 还原型β-烟酰胺单核苷酸钙盐的无定型及其制法和用途
WO2025142856A1 (ja) * 2023-12-25 2025-07-03 株式会社カネカ 還元型β－ニコチンアミドモノヌクレオチドのカルシウム塩及びその製造方法
WO2025142857A1 (ja) * 2023-12-25 2025-07-03 株式会社カネカ 還元型β－ニコチンアミドモノヌクレオチドの塩及びその製造方法
CN120424148B (zh) * 2024-02-02 2025-10-17 音芙医药科技(上海)有限公司 还原型β-烟酰胺单核苷酸盐及其组合物、制法和用途
CN118546191A (zh) * 2024-07-29 2024-08-27 邦泰生物工程(深圳)有限公司 还原型β-烟酰胺单核苷酸一钠盐晶型及其制备方法和应用
WO2026075119A1 (ja) * 2024-10-04 2026-04-09 株式会社カネカ 還元型ニコチンアミドモノヌクレオチドの製造方法
CN119143826B (zh) * 2024-11-19 2025-03-28 邦泰生物工程(深圳)有限公司 还原型β-烟酰胺单核苷酸二钠盐无定型化合物及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6352825B2 (ja) 2015-01-23 2018-07-04 株式会社ベスビオ 化粧料
EP3274357B1 (en) * 2015-03-27 2019-12-11 Cornell University Efficient synthesis of nicotinamide mononucleotide
KR20250080927A (ko) 2018-05-15 2025-06-05 점프스타트 퍼틸리티 피티와이 엘티디 노화방지제로서의 니코틴산 모노뉴클레오타이드의 무기 염
AU2019314476A1 (en) 2018-08-01 2021-02-25 Roland Dolle Quaternary ammonium salts of nicotinic acid and nicotinamide mononucloetides and ribosides as anti-aging agents
CN109350622A (zh) 2018-10-17 2019-02-19 深圳市龙格生技术有限公司 烟酰胺核糖及其衍生物与吡咯喹啉醌及其钠盐的组合工艺
WO2021098725A1 (en) 2019-11-19 2021-05-27 Tsinghua University Synthetic method for nmn derivative and medical applications of nmn and its derivative
CN110845548B (zh) * 2019-11-22 2021-02-09 武汉一若生物材料有限公司 一种制备β-烟酰胺单核苷酸及其钠盐的方法
CN112538101B (zh) * 2020-08-13 2026-02-03 常州博海威医药科技股份有限公司 一种β烟酰胺单核苷酸的新晶型及其制备方法和用途
CN114075582A (zh) 2020-08-18 2022-02-22 弈柯莱生物科技(上海)股份有限公司 一种d-核糖-5-磷酸的制备方法和应用
CN113332304A (zh) 2021-06-08 2021-09-03 深圳市旷逸生物科技有限公司 烟酰胺单核苷酸在制备心肌缺血再灌注损伤药物中的应用
CN113292619B (zh) * 2021-06-18 2022-04-22 邦泰生物工程(深圳)有限公司 烟酰胺单核苷酸-异烟碱共晶体及其组合物
CN115368423B (zh) * 2022-02-23 2025-05-09 音芙医药科技(上海)有限公司 还原型β-烟酰胺单核苷酸二钠盐的多晶型及其制法和用途

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