KR20240116537A - dsRNA, 이의 제조 방법 및 응용 - Google Patents
dsRNA, 이의 제조 방법 및 응용 Download PDFInfo
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- KR20240116537A KR20240116537A KR1020247022568A KR20247022568A KR20240116537A KR 20240116537 A KR20240116537 A KR 20240116537A KR 1020247022568 A KR1020247022568 A KR 1020247022568A KR 20247022568 A KR20247022568 A KR 20247022568A KR 20240116537 A KR20240116537 A KR 20240116537A
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- dsrna
- antisense strand
- sense strand
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
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- Organic Chemistry (AREA)
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- Wood Science & Technology (AREA)
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- Epidemiology (AREA)
- Virology (AREA)
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- Oncology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111542797.4 | 2021-12-16 | ||
| CN202111542797 | 2021-12-16 | ||
| PCT/CN2022/139488 WO2023109938A1 (zh) | 2021-12-16 | 2022-12-16 | 一种dsRNA、其制备方法及应用 |
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| KR20240116537A true KR20240116537A (ko) | 2024-07-29 |
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Family Applications (1)
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| KR1020247022568A Pending KR20240116537A (ko) | 2021-12-16 | 2022-12-16 | dsRNA, 이의 제조 방법 및 응용 |
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| JP (1) | JP2025500860A (https=) |
| KR (1) | KR20240116537A (https=) |
| CN (1) | CN118302526A (https=) |
| CA (1) | CA3240651A1 (https=) |
| TW (1) | TW202334425A (https=) |
| WO (1) | WO2023109938A1 (https=) |
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| WO2024125636A1 (zh) * | 2022-12-16 | 2024-06-20 | 上海拓界生物医药科技有限公司 | Toll样受体调节剂与dsRNA的联合治疗 |
| CN119816597A (zh) * | 2023-08-10 | 2025-04-11 | 石药集团中奇制药技术(石家庄)有限公司 | 一种抑制HBV基因表达的dsRNA分子及其应用 |
| CN116854754B (zh) | 2023-09-01 | 2023-12-12 | 北京悦康科创医药科技股份有限公司 | 一种含有核糖环或其衍生结构的GalNAc化合物及其寡核苷酸缀合物 |
| CN118638166B (zh) | 2024-08-15 | 2024-12-17 | 北京悦康科创医药科技股份有限公司 | 含有三氮唑结构的GalNAc化合物及其寡核苷酸缀合物 |
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| KR101773551B1 (ko) * | 2008-10-15 | 2017-08-31 | 아이오니스 파마수티컬즈, 인코포레이티드 | 인자 11 발현의 조정 |
| EA024762B9 (ru) * | 2011-06-30 | 2017-04-28 | Эрроухэд Рисерч Корпорейшн | Композиции и способы ингибирования экспрессии генов вируса гепатита в |
| EP3719127A4 (en) * | 2017-12-01 | 2021-10-20 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, COMPOSITION AND CONJUGATE WITH IT, MANUFACTURING METHOD AND USE |
| CN111378655B (zh) * | 2018-12-28 | 2024-03-19 | 苏州瑞博生物技术股份有限公司 | 抑制CTGF基因表达的siRNA、含有该siRNA的药物组合物及其用途 |
| AU2020280439B2 (en) * | 2019-05-22 | 2025-08-14 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| KR20220011689A (ko) * | 2019-05-22 | 2022-01-28 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 핵산, 약제학적 조성물, 접합체, 제조 방법, 및 용도 |
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2022
- 2022-12-16 CN CN202280076303.4A patent/CN118302526A/zh active Pending
- 2022-12-16 CA CA3240651A patent/CA3240651A1/en active Pending
- 2022-12-16 KR KR1020247022568A patent/KR20240116537A/ko active Pending
- 2022-12-16 TW TW111148551A patent/TW202334425A/zh unknown
- 2022-12-16 JP JP2024535520A patent/JP2025500860A/ja active Pending
- 2022-12-16 WO PCT/CN2022/139488 patent/WO2023109938A1/zh not_active Ceased
Also Published As
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| CN118302526A (zh) | 2024-07-05 |
| CA3240651A1 (en) | 2023-06-22 |
| WO2023109938A1 (zh) | 2023-06-22 |
| TW202334425A (zh) | 2023-09-01 |
| JP2025500860A (ja) | 2025-01-15 |
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