KR20240083095A - 항-lag3 항체, 약학 조성물 및 용도 - Google Patents

항-lag3 항체, 약학 조성물 및 용도 Download PDF

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KR20240083095A
KR20240083095A KR1020247012890A KR20247012890A KR20240083095A KR 20240083095 A KR20240083095 A KR 20240083095A KR 1020247012890 A KR1020247012890 A KR 1020247012890A KR 20247012890 A KR20247012890 A KR 20247012890A KR 20240083095 A KR20240083095 A KR 20240083095A
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antibody
cancer
seq
antigen
chain variable
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유 시아
종민 왕
펭 장
바이용 리
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아케소 바이오파마, 인크.
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KR1020247012890A 2021-09-29 2022-09-28 항-lag3 항체, 약학 조성물 및 용도 Pending KR20240083095A (ko)

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CN202111149114.9 2021-09-29
CN202111149114 2021-09-29
PCT/CN2022/122185 WO2023051621A1 (zh) 2021-09-29 2022-09-28 抗lag3抗体、药物组合物及用途

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KR1020247014429A Pending KR20240083096A (ko) 2021-09-29 2022-09-29 항-lag3 이중특이적 항체, 약학 조성물 및 용도

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US (2) US20250042995A1 (enExample)
EP (2) EP4410835A4 (enExample)
JP (2) JP2024536881A (enExample)
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CN (2) CN115873116A (enExample)
AU (2) AU2022355381A1 (enExample)
CA (2) CA3233205A1 (enExample)
IL (2) IL311738A (enExample)
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Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7753186B2 (ja) * 2019-08-02 2025-10-14 シーティーティーキュー-アケソ(シャンハイ) バイオメド テク カンパニー リミテッド 抗pd-1抗体およびその医学的使用
IL311738A (en) * 2021-09-29 2024-05-01 Akeso Biopharma Inc ANTI-LAG3 antibody, drug composition and use
CN119971023A (zh) * 2023-11-02 2025-05-13 正大天晴(广州)医药有限公司 含抗lag-3抗体的药物组合物及其用途
WO2025201450A1 (zh) * 2024-03-27 2025-10-02 康方汇科(上海)生物有限公司 药物组合及用途
WO2025232896A1 (zh) * 2024-05-10 2025-11-13 康方汇科(上海)生物有限公司 药物组合及用途
CN120518768A (zh) * 2025-05-30 2025-08-22 中国人民解放军军事科学院军事医学研究院 抗lag-3的单克隆抗体、抗pd-1与lag-3的双特异性抗体、制备方法及其应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
UY34887A (es) * 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
KR20160055269A (ko) * 2013-09-20 2016-05-17 브리스톨-마이어스 스큅 컴퍼니 종양을 치료하기 위한 항-lag-3 항체 및 항-pd-1 항체의 조합물
EP3556775B1 (en) * 2014-01-28 2021-11-17 Bristol-Myers Squibb Company Anti-lag-3 antibodies to treat hematological malignancies
JO3663B1 (ar) * 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
CN106632674B (zh) 2015-10-30 2018-11-16 泽达生物医药有限公司 一种抗pd-1单克隆抗体、其药物组合物及其用途
BR112018012352A2 (pt) * 2015-12-16 2018-12-11 Merck Sharp & Dohme Corp. anticorpos anti-lag3 e fragmentos de ligação ao antígeno
WO2017218707A2 (en) * 2016-06-14 2017-12-21 Xencor, Inc. Bispecific checkpoint inhibitor antibodies
US11214618B2 (en) * 2016-06-20 2022-01-04 F-Star Therapeutics Limited LAG-3 binding members
CN106977602B (zh) 2016-08-23 2018-09-25 中山康方生物医药有限公司 一种抗pd1单克隆抗体、其药物组合物及其用途
CN106967172B (zh) 2016-08-23 2019-01-08 康方药业有限公司 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途
US11285207B2 (en) * 2017-04-05 2022-03-29 Hoffmann-La Roche Inc. Bispecific antibodies specifically binding to PD1 and LAG3
WO2018217940A2 (en) * 2017-05-24 2018-11-29 Sutro Biopharma, Inc. Pd-1/lag3 bi-specific antibodies, compositions thereof, and methods of making and using the same
IL322104A (en) * 2017-05-30 2025-09-01 Bristol Myers Squibb Co Treatment of lag-3 positive tumors
KR20200104314A (ko) * 2017-12-22 2020-09-03 지앙수 헨그루이 메디슨 컴퍼니 리미티드 Lag-3 항체 약학 조성물 및 이의 용도
WO2019148412A1 (en) * 2018-02-01 2019-08-08 Merck Sharp & Dohme Corp. Anti-pd-1/lag3 bispecific antibodies
CN110615840A (zh) * 2018-06-19 2019-12-27 信达生物制药(苏州)有限公司 全人源的抗lag-3抗体及其应用
JP7177543B2 (ja) * 2018-08-21 2022-11-24 エービーエル バイオ インコーポレイテッド 抗pd-l1/抗lag3二重特異性抗体およびその使用
CN112010972B (zh) * 2019-05-31 2023-01-10 瑞阳(苏州)生物科技有限公司 与人lag-3蛋白结合的抗体及其编码基因和应用
CN112079925B (zh) * 2019-06-13 2025-04-25 上海健信生物医药科技有限公司 靶向lag-3的抗体和双特异性抗体及其用途
US20240425593A1 (en) * 2019-09-30 2024-12-26 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Anti-pd-1 antibody and use thereof
BR112022010069A2 (pt) * 2019-11-25 2022-09-06 Akeso Biopharma Inc Anticorpo biespecífico, molécula de ácido nucleico isolada, vetor, célula hospedeira, conjugado, kit, uso do anticorpo biespecífico e composição farmacêutica
JP2023507848A (ja) * 2019-12-23 2023-02-27 マクロジェニクス,インコーポレーテッド 癌の治療のための療法
WO2021136392A1 (zh) * 2019-12-30 2021-07-08 上海海路生物技术有限公司 Lag-3抗体及其医药用途
CN114945595A (zh) * 2020-01-21 2022-08-26 上海复宏汉霖生物技术股份有限公司 抗lag3单克隆抗体及其制备方法和应用
CN115073588B (zh) * 2021-03-12 2024-06-18 中山康方生物医药有限公司 提高含有免疫球蛋白Fc片段的药物的安全性的方法
IL311738A (en) * 2021-09-29 2024-05-01 Akeso Biopharma Inc ANTI-LAG3 antibody, drug composition and use

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