KR20240083095A - 항-lag3 항체, 약학 조성물 및 용도 - Google Patents
항-lag3 항체, 약학 조성물 및 용도 Download PDFInfo
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- KR20240083095A KR20240083095A KR1020247012890A KR20247012890A KR20240083095A KR 20240083095 A KR20240083095 A KR 20240083095A KR 1020247012890 A KR1020247012890 A KR 1020247012890A KR 20247012890 A KR20247012890 A KR 20247012890A KR 20240083095 A KR20240083095 A KR 20240083095A
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A61P7/06—Antianaemics
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/00—Immunoglobulins specific features
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- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111149114.9 | 2021-09-29 | ||
| CN202111149114 | 2021-09-29 | ||
| PCT/CN2022/122185 WO2023051621A1 (zh) | 2021-09-29 | 2022-09-28 | 抗lag3抗体、药物组合物及用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20240083095A true KR20240083095A (ko) | 2024-06-11 |
Family
ID=85770153
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247012890A Pending KR20240083095A (ko) | 2021-09-29 | 2022-09-28 | 항-lag3 항체, 약학 조성물 및 용도 |
| KR1020247014429A Pending KR20240083096A (ko) | 2021-09-29 | 2022-09-29 | 항-lag3 이중특이적 항체, 약학 조성물 및 용도 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247014429A Pending KR20240083096A (ko) | 2021-09-29 | 2022-09-29 | 항-lag3 이중특이적 항체, 약학 조성물 및 용도 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20250042995A1 (enExample) |
| EP (2) | EP4410835A4 (enExample) |
| JP (2) | JP2024536881A (enExample) |
| KR (2) | KR20240083095A (enExample) |
| CN (2) | CN115873116A (enExample) |
| AU (2) | AU2022355381A1 (enExample) |
| CA (2) | CA3233205A1 (enExample) |
| IL (2) | IL311738A (enExample) |
| MX (2) | MX2024003936A (enExample) |
| WO (2) | WO2023051621A1 (enExample) |
| ZA (2) | ZA202403273B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7753186B2 (ja) * | 2019-08-02 | 2025-10-14 | シーティーティーキュー-アケソ(シャンハイ) バイオメド テク カンパニー リミテッド | 抗pd-1抗体およびその医学的使用 |
| IL311738A (en) * | 2021-09-29 | 2024-05-01 | Akeso Biopharma Inc | ANTI-LAG3 antibody, drug composition and use |
| CN119971023A (zh) * | 2023-11-02 | 2025-05-13 | 正大天晴(广州)医药有限公司 | 含抗lag-3抗体的药物组合物及其用途 |
| WO2025201450A1 (zh) * | 2024-03-27 | 2025-10-02 | 康方汇科(上海)生物有限公司 | 药物组合及用途 |
| WO2025232896A1 (zh) * | 2024-05-10 | 2025-11-13 | 康方汇科(上海)生物有限公司 | 药物组合及用途 |
| CN120518768A (zh) * | 2025-05-30 | 2025-08-22 | 中国人民解放军军事科学院军事医学研究院 | 抗lag-3的单克隆抗体、抗pd-1与lag-3的双特异性抗体、制备方法及其应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| UY34887A (es) * | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
| KR20160055269A (ko) * | 2013-09-20 | 2016-05-17 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하기 위한 항-lag-3 항체 및 항-pd-1 항체의 조합물 |
| EP3556775B1 (en) * | 2014-01-28 | 2021-11-17 | Bristol-Myers Squibb Company | Anti-lag-3 antibodies to treat hematological malignancies |
| JO3663B1 (ar) * | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| CN106632674B (zh) | 2015-10-30 | 2018-11-16 | 泽达生物医药有限公司 | 一种抗pd-1单克隆抗体、其药物组合物及其用途 |
| BR112018012352A2 (pt) * | 2015-12-16 | 2018-12-11 | Merck Sharp & Dohme Corp. | anticorpos anti-lag3 e fragmentos de ligação ao antígeno |
| WO2017218707A2 (en) * | 2016-06-14 | 2017-12-21 | Xencor, Inc. | Bispecific checkpoint inhibitor antibodies |
| US11214618B2 (en) * | 2016-06-20 | 2022-01-04 | F-Star Therapeutics Limited | LAG-3 binding members |
| CN106977602B (zh) | 2016-08-23 | 2018-09-25 | 中山康方生物医药有限公司 | 一种抗pd1单克隆抗体、其药物组合物及其用途 |
| CN106967172B (zh) | 2016-08-23 | 2019-01-08 | 康方药业有限公司 | 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 |
| US11285207B2 (en) * | 2017-04-05 | 2022-03-29 | Hoffmann-La Roche Inc. | Bispecific antibodies specifically binding to PD1 and LAG3 |
| WO2018217940A2 (en) * | 2017-05-24 | 2018-11-29 | Sutro Biopharma, Inc. | Pd-1/lag3 bi-specific antibodies, compositions thereof, and methods of making and using the same |
| IL322104A (en) * | 2017-05-30 | 2025-09-01 | Bristol Myers Squibb Co | Treatment of lag-3 positive tumors |
| KR20200104314A (ko) * | 2017-12-22 | 2020-09-03 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | Lag-3 항체 약학 조성물 및 이의 용도 |
| WO2019148412A1 (en) * | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anti-pd-1/lag3 bispecific antibodies |
| CN110615840A (zh) * | 2018-06-19 | 2019-12-27 | 信达生物制药(苏州)有限公司 | 全人源的抗lag-3抗体及其应用 |
| JP7177543B2 (ja) * | 2018-08-21 | 2022-11-24 | エービーエル バイオ インコーポレイテッド | 抗pd-l1/抗lag3二重特異性抗体およびその使用 |
| CN112010972B (zh) * | 2019-05-31 | 2023-01-10 | 瑞阳(苏州)生物科技有限公司 | 与人lag-3蛋白结合的抗体及其编码基因和应用 |
| CN112079925B (zh) * | 2019-06-13 | 2025-04-25 | 上海健信生物医药科技有限公司 | 靶向lag-3的抗体和双特异性抗体及其用途 |
| US20240425593A1 (en) * | 2019-09-30 | 2024-12-26 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Anti-pd-1 antibody and use thereof |
| BR112022010069A2 (pt) * | 2019-11-25 | 2022-09-06 | Akeso Biopharma Inc | Anticorpo biespecífico, molécula de ácido nucleico isolada, vetor, célula hospedeira, conjugado, kit, uso do anticorpo biespecífico e composição farmacêutica |
| JP2023507848A (ja) * | 2019-12-23 | 2023-02-27 | マクロジェニクス,インコーポレーテッド | 癌の治療のための療法 |
| WO2021136392A1 (zh) * | 2019-12-30 | 2021-07-08 | 上海海路生物技术有限公司 | Lag-3抗体及其医药用途 |
| CN114945595A (zh) * | 2020-01-21 | 2022-08-26 | 上海复宏汉霖生物技术股份有限公司 | 抗lag3单克隆抗体及其制备方法和应用 |
| CN115073588B (zh) * | 2021-03-12 | 2024-06-18 | 中山康方生物医药有限公司 | 提高含有免疫球蛋白Fc片段的药物的安全性的方法 |
| IL311738A (en) * | 2021-09-29 | 2024-05-01 | Akeso Biopharma Inc | ANTI-LAG3 antibody, drug composition and use |
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2022
- 2022-09-28 IL IL311738A patent/IL311738A/en unknown
- 2022-09-28 US US18/696,559 patent/US20250042995A1/en active Pending
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- 2022-09-28 CA CA3233205A patent/CA3233205A1/en active Pending
- 2022-09-28 WO PCT/CN2022/122185 patent/WO2023051621A1/zh not_active Ceased
- 2022-09-28 AU AU2022355381A patent/AU2022355381A1/en active Pending
- 2022-09-28 CN CN202211192782.4A patent/CN115873116A/zh active Pending
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- 2022-09-28 EP EP22875004.8A patent/EP4410835A4/en active Pending
- 2022-09-28 JP JP2024519329A patent/JP2024536881A/ja active Pending
- 2022-09-29 CN CN202211199026.4A patent/CN115873123A/zh active Pending
- 2022-09-29 IL IL311692A patent/IL311692A/en unknown
- 2022-09-29 MX MX2024003935A patent/MX2024003935A/es unknown
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- 2022-09-29 JP JP2024520079A patent/JP2024538669A/ja active Pending
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2024
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Also Published As
| Publication number | Publication date |
|---|---|
| US20240392040A1 (en) | 2024-11-28 |
| JP2024538669A (ja) | 2024-10-23 |
| WO2023051621A1 (zh) | 2023-04-06 |
| EP4410835A4 (en) | 2025-09-24 |
| JP2024536881A (ja) | 2024-10-08 |
| EP4410837A1 (en) | 2024-08-07 |
| CN115873123A (zh) | 2023-03-31 |
| US20250042995A1 (en) | 2025-02-06 |
| IL311692A (en) | 2024-05-01 |
| MX2024003936A (es) | 2024-06-28 |
| CA3233192A1 (en) | 2023-04-06 |
| EP4410837A4 (en) | 2025-10-08 |
| CA3233205A1 (en) | 2023-04-06 |
| ZA202403273B (en) | 2025-01-29 |
| MX2024003935A (es) | 2024-06-28 |
| AU2022355986A1 (en) | 2024-04-18 |
| CN115873116A (zh) | 2023-03-31 |
| KR20240083096A (ko) | 2024-06-11 |
| ZA202403275B (en) | 2025-02-26 |
| WO2023051683A1 (zh) | 2023-04-06 |
| IL311738A (en) | 2024-05-01 |
| AU2022355381A1 (en) | 2024-05-02 |
| EP4410835A1 (en) | 2024-08-07 |
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