KR20240055937A - Natural Fragrance Healing Oil Composition for Alleviating Depression - Google Patents

Abstract

The present invention relates to a natural aroma healing oil composition for improving depression. In the natural aroma healing oil composition, extracts of turmeric, prickly pear herb, inflorescence, parsley seed, ginger, red pine, valerian, tangerine and yellow chives are contained in a certain weight %. Characterized by mixing.

Description

Natural Fragrance Healing Oil Composition for Alleviating Depression}

The present invention relates to a natural aroma healing oil composition for improving depression, and more specifically, to a natural aroma healing oil composition for improving depression that has safety and effectiveness using extracts of natural ingredients and has excellent efficacy in improving depression. It's about.

Natural aroma oil refers to natural essential oils with aroma-to-therapy effects, and refers to 100% natural oils with vitality extracted from the flowers, leaves, stems, fruits, and roots of medicinal herbs.

There are about 70 types of natural aroma oils that can be used by the human body, and they can be used individually or in combination of 2 or 3 types depending on the purpose.

All plants have the ability to reproduce and grow themselves, heal diseases, and heal wounds. Natural aroma oil is an extract of the “life force” and “healing power” of these plants, and is used for aromatherapy purposes. Natural aroma oil of the highest quality should be used.

If it is not a natural aroma oil, it has no therapeutic effect and may have side effects that disrupt the body's rhythm.

Fragrance particles that produce therapeutic effects present in these natural aroma oils are highly volatile, easily soluble in fat or oil, are a complex of numerous ingredients, and have the characteristic of having a fragrant odor.

These fragrance particles are absorbed into the body through the sense of smell or the skin and provide a specific pharmacological effect. If we briefly look at the mechanism, first of all, in the case of olfaction, in which scent particles are absorbed in the fastest way, small scent particles are transmitted through the nose using air as a medium. When inhaled and delivered to the brain, different stimuli are delivered to the brain depending on the shape of the scent particles, and the brain that receives this stimulation produces neurochemicals that have effects such as calming, relaxation, stimulation, and happiness. Neurochemicals affect the pituitary gland to regulate hormone secretion and have a pharmacological effect on the body.

However, if safety and effectiveness are not secured, there is a risk of side effects, so there is a need to develop a natural aroma oil composition that ensures safety and effectiveness.

The present invention was created to solve the above-mentioned problems, and its purpose is to provide a natural aroma healing oil composition for improving depression that ensures safety and effectiveness using extracts of natural ingredients and is excellent in improving depression.

Meanwhile, the objects of the present invention are not limited to the objects mentioned above, and other objects not mentioned can be clearly understood by those skilled in the art from the description below.

In order to achieve the above-mentioned purpose, the natural aroma healing oil composition for improving depression according to an embodiment of the present invention first contains a certain weight of extracts of turmeric, pear herb, insinuum, parsley seed, ginger, red pine, valerian, tangerine and yellow chives. Can be mixed in %.

Preferably, the extracts of turmeric, pear root, persimmon, sour parsley seed, ginger, red pine, valerian, tangerine and yellow chili extract can be extracted using steam distillation extraction method.

Preferably, the turmeric, pear vinegar, persimmon, sour parsley seed, ginger, red pine, valerian, Tangerine and yellow chive extracts contain 6% by weight of turmeric extract, 3% by weight of pear herb extract, 30% by weight of persimmon extract, and 6% by weight of sour parsley seed extract. , 10% by weight of ginger extract, 20% by weight of red pine extract, 2% by weight of valerian extract, 20% by weight of Tangja extract, and 3% by weight of Hwangchil extract.

The natural aroma healing oil composition for improving depression according to an embodiment of the present invention secures safety and effectiveness by using natural ingredient extracts as described above through solution methods, and has an excellent effect in improving depression.

Figure 1 is a protocol image for an inhalation toxicity observation test of a natural aroma healing oil composition for improving depression according to an embodiment of the present invention.
Figure 2 is an image of a rating table for evaluating skin reactions of individual animals.
Figures 3 to 8 are test reports for each concentration showing the results of the inhalation toxicity observation test (Inhalation Toxicology).
Figures 9 and 10 are images showing the results of an open field test (OFT).
Figures 11 and 12 are images showing the results of a tail suspension test (TST).

The terms used in the present invention are general terms that are currently widely used as much as possible, but in certain cases, there are terms arbitrarily selected by the applicant. In this case, it is not a simple name of the term, but the meaning described or used in the specific content for practicing the invention. The meaning should be understood by taking into account.

In this regard, first, the natural aroma healing oil composition for improving depression according to an embodiment of the present invention is for producing a natural aroma healing oil for improving depression using natural extracts. In the present invention, the natural extract is turmeric. It is characterized by mixing extracts of pear herb scent, persimmon persimmon, parsley seed, ginger, red pine, valerian root, Tangerine root, and yellow chili extract at a certain weight percentage. In this case, the extraction method of the above-mentioned extracts is extracted using steam distillation extraction method.

Meanwhile, the reason why the natural aroma healing oil composition for improving depression according to an embodiment of the present invention uses the above-mentioned natural extract is as follows.

First, in the case of turmeric ( Curcuma aromatica ) extract, it is an ingredient that has effects such as antioxidant, anti-inflammatory, antibacterial, blood pressure lowering, obesity suppressing, whitening, detoxifying, scleroderma, psoriasis, and skin cancer prevention.

At this time, the turmeric is extracted using the steam distillation extraction method as described above, and more specifically, the turmeric is extracted using the steam distillation extraction method for 30 minutes at 100°C and 210 minutes at 65°C, and the extraction of all extracts described later. The conditions are the same.

Meanwhile, Agastache rugosa extract is an ingredient that has antioxidant, anti-inflammatory, fat cell differentiation inhibition, antibacterial activity, nematicidal activity, wrinkle improvement, stress and Alzheimer's alleviation activity, and anti-diabetic effect, and it is an ingredient that has anti-oxidation effect ( Citrus medica var. sarcodactylis). ) extract is effective in sterilizing, anti-inflammatory, antibacterial, whitening, relieving depression, relieving pain, suppressing microorganisms, and relieving inflammation.

Meanwhile, Aegopodium podagraria L extract is an extract that has antioxidant, antibacterial, diuretic, estrogenic, vascular relaxant, and antithrombotic effects, while ginger ( Zingiber officinale ) relieves indigestion, promotes blood circulation, prevents inflammation, and relieves indigestion. It is effective in alleviating depression, relieving stress, inducing sound sleep, and strengthening concentration.

In addition, red pine ( Pinus densiflora ) is effective in anti-inflammatory, film-forming, anti-aging, anti-viral, anti-inflammatory, anti-cancer, antibacterial, and anti-cancer microorganism effects, while valerian plant ( Valeriana fauriei ) has sterilizing, anti-inflammatory, antibacterial, and anti-cancer properties. It is effective in allergy, antioxidant, antibacterial, nerve stabilization, stress relief, inducing good sleep, fatigue recovery, strengthening concentration, preventing diabetes and suppressing microorganisms. It is an extract that is effective in promoting hair growth, stabilizing nerves, antioxidant, antiviral, improving immunity, and protecting blood vessels.

In addition, Dendropanax morbiferus is an extract effective for anti-inflammatory, sterilizing, anti-allergic, antioxidant, stress relieving, inducing good sleep, recovering from fatigue, strengthening concentration, alleviating abdominal pain, antibacterial and nervous disorders, according to an embodiment of the present invention. A natural aroma oil composition for improving depression utilizes the effects of each extract described above.

Meanwhile, the natural aroma healing oil composition for improving depression according to an embodiment of the present invention is characterized by mixing the above-mentioned natural ingredient extracts at a certain weight%.

At this time, the mixing ratio of the extracts according to the embodiment of the present invention is 6% by weight of turmeric extract, 3% by weight of pear herb extract, 30% by weight of water parsley extract, 6% by weight of wild water parsley seed extract, 10% by weight of ginger extract, and 20% by weight of red pine extract. By weight, it consists of 2% by weight of valerian extract, 20% by weight of Tangja extract, and 3% by weight of Hwangchil extract.

The reason for numerically limiting the weight % of the extracts in this way is to achieve the optimal depression improvement effect through the limited numerical range of the extracts.

Hereinafter, the effect of a natural aroma healing oil for improving depression containing a composition according to an embodiment of the present invention will be described in detail with reference to FIGS. 1 to 12.

1. Safety confirmation test

1) Inhalation Toxicology

Inhalation toxicity testing is a field of testing that evaluates the toxic effects in the living body caused by substances inhaled through the respiratory tract. It includes tests to check the toxicity caused by inhalation of inhaled drugs, biological drugs, pesticides, chemicals, and environmental hazardous substances. says

The forms inhaled into the living body applied in this test are Mist and Gas, and nasal exposure and whole body exposure were performed by inhalation exposure to animals (rodents), and the presence of irritation around the nose and skin is evaluated based on the following criteria.

① The skin reaction of each animal is scored using an evaluation rating table (see Figure 2).

The erythema and edema scores of the test substances are added, and the average value is taken as the primary skin irritation index.

② Irritation of the test substance is evaluated separately according to Table 1 below with the highest primary skin irritation index.

At this time, the irritancy of the test substance must be evaluated considering clinical symptoms observed during the test period in addition to the primary skin irritation index.

Primary skin irritation index classification 0.0 ~ 1.0 Non-irritating 1.1 ~ 2.0 mild irritant 2.1 ~ 5.0 moderate irritant 5.1 ~ 8.0 strong irritant

Meanwhile, the concentration of natural aroma that is non-irritating was confirmed through the primary skin irritation index for each test substance, and all animal experiments were conducted with permission from Wonkwang University's Animal Testing Ethics Committee (approval number: WKU22-49).

2) Results of inhalation toxicity observation test (Inhalation Toxicology)

As a result of the exposure type being Mist and Gas, the natural aroma concentration confirming the hypoallergenicity of natural aroma oil was confirmed through an inhalation toxicity test by concentration, and the results of the rat with the highest primary skin irritation index for each group were recorded. The v_0.5%, v_1.0%, and v_1.5% samples were all confirmed to be non-irritating with a primary skin irritation index of 0.0.

Reports for each concentration (experiment detailed data results) are shown in Figures 3 to 8.

2. Observation experiment for effectiveness

1) Open field test (OFT)

To investigate the effect of scent healing on activity, behavior was observed in an open field.

The open field used in the experiment was a box made of acrylic with dimensions of 50 It was sprayed three times in a time cycle (9:00, 13:00, 17:00), and after scent healing for a total of 5 days, behavior in an open field was observed for 6 minutes and walking activity, climbing posture, etc. were recorded.

Walking activity was calculated by moving the checkerboard in an open field, and climbing posture was calculated based on lifting the upper body for more than 1 second and touching the wall with the front feet. The groups were divided into normal group, control group, and experimental group. A group is defined as follows:

- Normal group: A group of experimental animals raised without scent therapy

- Control group: The effect of each experiment was confirmed without scent healing.

The group that caused the desired symptom (depression)

- Experimental group: A group of experimental animals administered scent therapy by dose or time.

Meanwhile, the data of all experimental results were expressed as mean ± S.D. Statistical significance was expressed as P-value through an independent sample T-test test using SPSS 26.0 (SPSS Inc., USA) program, and P-value was * They were classified as (p<0.05), **(p<0.01), and ***(p<0.001), respectively.

2) Open field test (OFT) results

Referring to Figure 9, an animal model of depression whose activity was significantly reduced through periodic exposure to stress (forced swimming) for 3 days was subjected to scent healing 3 times a day for 4 hours for 5 days, and then walked through an open field experiment for 6 minutes. Activity and climbing posture were measured to confirm the antidepressant effect by scent concentration, and it was confirmed that walking activity significantly increased in the V_0.5% group compared to the control group. (In this case, "V" = mixed oil of 9 natural extracts lim.)

An independent samples T test was conducted to determine whether activity improved depending on the scent sample.

As a result, in the V_0.5% group, t=-3.461, p=0.003 was found to be statistically significant based on the significance level of 0.01. Therefore, the null hypothesis was rejected and the alternative hypothesis was adopted, 'There is a difference between the control group and the V_0.5% walking group. It can be said that there is a ‘difference in activity averages’. The control group had an average of 122.4 times, and the V_0.5% had 146.70 times, showing a relatively higher average number of activities in the V_0.5% group than the depression model.

3) Tail suspension test (TST)

The antidepressant effect by tail suspension experiment was conducted according to the method of Steru et al.

Rats with dangling tails move actively at first, but when they become depressed due to stress, they show a still and immobile posture and alternate between these movements. When anti-kid therapy is performed, the time in which the immobility is shown (duration of immobility) is reduced. was measured to confirm the antidepressant effect.

Fragrance healing was sprayed 3 times a day in a 4-hour cycle (9:00, 1:00, 17:00). After scent healing for a total of 5 days, the tail of the white rat was attached to the test rod with painless tape and treated for 6 minutes under lighting with noise blocked. While the tail suspension method was performed, the time spent in an immobile posture was measured.

The groups were divided into normal group, control group, and experimental group, and each group was defined as follows.

- Normal group: A group of experimental animals raised without scent therapy

- Control group: The effect of each experiment was confirmed without scent healing.

The group that caused the desired symptom (depression)

- Experimental group: A group of experimental animals administered scent therapy by dose or time.

The data of all experimental results were expressed as mean ± S.D. Statistical significance was expressed as P-value through an independent sample T-test using the SPSS 26.0 (SPSS Inc., USA) program, and P-value was *(p <0.05), **(p<0.01), and ***(p<0.001).

4) Tail suspension test (TST) results

An animal model of depression whose activity was significantly reduced through periodic exposure to stress (forced swimming) for 3 days was subjected to scent healing 3 times a day for 4 hours for 5 days. Afterwards, immobility was measured through a tail suspension experiment for 6 minutes, and the scent concentration was evaluated. The antidepressant effect was confirmed, and it was confirmed that immobility time was significantly shorter in the V_1.5% group compared to the control group.

In the V_1.5% group, t = 3.419, p = 0.002, which was statistically significant based on the significance level of 0.01. Therefore, the null hypothesis was rejected and the alternative hypothesis was adopted, 'The average difference in immobility time between the control group and V_1.5% 'It can be said that there is.

The control group had an average of 164.70 seconds, and the V_1.5% group had an average of 148.21 seconds, showing a relatively higher average activity time in the V_1.5% group than in the depression model.

As a result, the natural aroma healing oil composition for improving depression according to an embodiment of the present invention secures safety and effectiveness by using natural ingredient extracts and has an excellent effect in improving depression.

As discussed above, the present invention has been illustrated and described by way of preferred embodiments, but it is not limited to the above-described embodiments and is intended to be used by those skilled in the art without departing from the spirit of the invention. Various changes and modifications may be possible.

Claims (3)

In the natural aroma healing oil composition,
A natural aroma healing oil composition for improving depression, characterized by a mixture of extracts of turmeric, pear herb, persimmon, parsley seed, ginger, red pine, valerian, tangerine and yellow chili extract at a certain weight percentage.
According to claim 1,
A natural aroma healing oil composition for improving depression, wherein the extracts of turmeric, pear root, persimmon, parsley seed, ginger, red pine, valerian, tangerine and yellow chive extract are extracted using a steam distillation extraction method.
According to clause 2,
The turmeric, pear vinegar, persimmon, sour parsley seed, ginger, red pine, valerian, Tangerine and yellow chive extracts are 6% by weight of turmeric extract, 3% by weight of pear vinegar extract, 30% by weight of persimmon extract, 6% by weight of sour parsley seed extract, and ginger. A natural aroma healing oil composition for improving depression, comprising 10% by weight of extract, 20% by weight of red pine extract, 2% by weight of valerian extract, 20% by weight of Tangerine extract, and 3% by weight of Hwangchil extract.