KR20240040799A - 감마 델타 t 세포 및 이의 조성물의 조작 - Google Patents

감마 델타 t 세포 및 이의 조성물의 조작 Download PDF

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KR20240040799A
KR20240040799A KR1020247006876A KR20247006876A KR20240040799A KR 20240040799 A KR20240040799 A KR 20240040799A KR 1020247006876 A KR1020247006876 A KR 1020247006876A KR 20247006876 A KR20247006876 A KR 20247006876A KR 20240040799 A KR20240040799 A KR 20240040799A
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cells
population
days
viral vector
car
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Korean (ko)
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이스트반 코박스
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감마델타 테라퓨틱스 엘티디
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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  • Gastroenterology & Hepatology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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KR1020247006876A 2021-08-03 2022-08-03 감마 델타 t 세포 및 이의 조성물의 조작 Pending KR20240040799A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163228972P 2021-08-03 2021-08-03
US63/228,972 2021-08-03
PCT/GB2022/052039 WO2023012475A1 (en) 2021-08-03 2022-08-03 Engineering of gamma delta t cells and compositions thereof

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KR20240040799A true KR20240040799A (ko) 2024-03-28

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KR1020247006876A Pending KR20240040799A (ko) 2021-08-03 2022-08-03 감마 델타 t 세포 및 이의 조성물의 조작

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US (1) US20240344024A1 (https=)
EP (1) EP4381075A1 (https=)
JP (1) JP2024529015A (https=)
KR (1) KR20240040799A (https=)
CN (1) CN117795083A (https=)
AR (1) AR126690A1 (https=)
AU (1) AU2022322052A1 (https=)
CA (1) CA3228168A1 (https=)
CO (1) CO2024002241A2 (https=)
MX (1) MX2024001657A (https=)
TW (1) TW202328434A (https=)
WO (1) WO2023012475A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4504247A1 (en) 2022-04-04 2025-02-12 Gammadelta Therapeutics Ltd Novel gene armoring
CN119020418B (zh) * 2024-08-17 2025-06-13 广东君厚生物医药有限公司 BaEV逆转录病毒载体的包装方法及其包装细胞系

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801030A (en) 1995-09-01 1998-09-01 Genvec, Inc. Methods and vectors for site-specific recombination
US6136597A (en) 1997-09-18 2000-10-24 The Salk Institute For Biological Studies RNA export element
EP1777294A1 (en) 2005-10-20 2007-04-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
PT2710123T (pt) 2011-05-19 2017-10-13 Inst De Medicina Molecular Linha celular de linfócitos compreendendo células t gama-delta, método de composição e produção resultante dos mesmos
AU2016274633B2 (en) 2015-06-09 2022-04-21 Gammadelta Therapeutics Ltd Methods for the production of TCR gamma delta+ T cells
WO2017072367A1 (en) 2015-10-30 2017-05-04 Cancer Research Technology Limited EXPANSION OF NON-HAEMATOPOIETIC TISSUE-RESIDENT γδ T CELLS AND USES OF THESE CELLS
DE102017127984B4 (de) * 2017-11-27 2019-12-05 Immatics US, Inc. Verfahren für die Vermehrung und Aktivierung von γδ-T-Zellen
CN113423820A (zh) 2018-11-08 2021-09-21 伽马三角洲疗法有限公司 分离和扩增细胞的方法
GB201818243D0 (en) 2018-11-08 2018-12-26 Gammadelta Therapeutics Ltd Methods for isolating and expanding cells

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WO2023012475A1 (en) 2023-02-09
US20240344024A1 (en) 2024-10-17
AU2022322052A1 (en) 2024-02-29
CN117795083A (zh) 2024-03-29
EP4381075A1 (en) 2024-06-12
MX2024001657A (es) 2024-04-19
JP2024529015A (ja) 2024-08-01
TW202328434A (zh) 2023-07-16
CA3228168A1 (en) 2023-02-09
CO2024002241A2 (es) 2024-03-07
AR126690A1 (es) 2023-11-01

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