KR20240038723A - 메소텔린을 특이적으로 표적화하는 car-발현 면역 세포 및 이의 용도 - Google Patents

메소텔린을 특이적으로 표적화하는 car-발현 면역 세포 및 이의 용도 Download PDF

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KR20240038723A
KR20240038723A KR1020247003396A KR20247003396A KR20240038723A KR 20240038723 A KR20240038723 A KR 20240038723A KR 1020247003396 A KR1020247003396 A KR 1020247003396A KR 20247003396 A KR20247003396 A KR 20247003396A KR 20240038723 A KR20240038723 A KR 20240038723A
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nucleic acid
sequence
acid molecule
sequence identity
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개리 샤피로
치히로 타케
요시아키 카사이
싱위에 헤
찬탈 쿤
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다케다 야쿠힝 고교 가부시키가이샤
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Publication of KR20240038723A publication Critical patent/KR20240038723A/ko
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/35—Cytokines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4254—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • A61K40/4255—Mesothelin [MSLN]
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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KR1020247003396A 2021-07-29 2022-07-28 메소텔린을 특이적으로 표적화하는 car-발현 면역 세포 및 이의 용도 Pending KR20240038723A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163227115P 2021-07-29 2021-07-29
US63/227,115 2021-07-29
US202263306862P 2022-02-04 2022-02-04
US63/306,862 2022-02-04
PCT/US2022/038640 WO2023009700A2 (en) 2021-07-29 2022-07-28 Car-expressing immune cells that specifically target mesothelin and uses thereof

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KR20240038723A true KR20240038723A (ko) 2024-03-25

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KR1020247003396A Pending KR20240038723A (ko) 2021-07-29 2022-07-28 메소텔린을 특이적으로 표적화하는 car-발현 면역 세포 및 이의 용도

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US (1) US20240374721A1 (https=)
EP (1) EP4377355A4 (https=)
JP (1) JP2024528052A (https=)
KR (1) KR20240038723A (https=)
AU (1) AU2022316980A1 (https=)
CA (1) CA3227745A1 (https=)
CO (1) CO2024001484A2 (https=)
IL (1) IL309914A (https=)
MX (1) MX2024001364A (https=)
TW (1) TW202313979A (https=)
WO (1) WO2023009700A2 (https=)

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Publication number Priority date Publication date Assignee Title
CN112771166B (zh) * 2018-08-31 2025-03-04 诺伊尔免疫生物科技株式会社 表达car的t细胞和car表达载体
AU2024263914A1 (en) 2023-04-27 2025-12-04 Takeda Pharmaceutical Company Limited Method for expanding cd56+/cd3- cells
CN119101166A (zh) * 2023-06-08 2024-12-10 博生吉医药科技(苏州)有限公司 B7-H3嵌合抗原受体修饰的Vδ1 T细胞及其应用
WO2025140683A1 (zh) * 2023-12-29 2025-07-03 北京鼎成肽源生物技术有限公司 表达趋化因子10和白介素15的工程化免疫细胞

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013063419A2 (en) 2011-10-28 2013-05-02 The Trustees Of The University Of Pennsylvania A fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
WO2020045610A1 (ja) 2018-08-31 2020-03-05 ノイルイミューン・バイオテック株式会社 Ｃａｒ発現ｔ細胞及びｃａｒ発現ベクター
US20200101142A1 (en) 2017-06-12 2020-04-02 Obsidian Therapeutics, Inc. Pde5 compositions and methods for immunotherapy

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108728458B (zh) * 2017-04-21 2021-11-16 上海恒润达生生物科技股份有限公司 靶向mesothelin的嵌合抗原受体并联合表达IL-15的方法和用途
CN118948892A (zh) * 2017-05-01 2024-11-15 朱诺治疗学股份有限公司 细胞疗法与免疫调节化合物的组合
WO2019124468A1 (ja) * 2017-12-24 2019-06-27 ノイルイミューン・バイオテック株式会社 ヒトメソセリンを特異的に認識する細胞表面分子、ｉｌ－７、及びｃｃｌ１９を発現する免疫担当細胞
US20200399383A1 (en) * 2018-02-13 2020-12-24 Novartis Ag Chimeric antigen receptor therapy in combination with il-15r and il15

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013063419A2 (en) 2011-10-28 2013-05-02 The Trustees Of The University Of Pennsylvania A fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
US20200101142A1 (en) 2017-06-12 2020-04-02 Obsidian Therapeutics, Inc. Pde5 compositions and methods for immunotherapy
WO2020045610A1 (ja) 2018-08-31 2020-03-05 ノイルイミューン・バイオテック株式会社 Ｃａｒ発現ｔ細胞及びｃａｒ発現ベクター

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CA3227745A1 (en) 2023-02-02
WO2023009700A2 (en) 2023-02-02
JP2024528052A (ja) 2024-07-26
IL309914A (en) 2024-03-01
TW202313979A (zh) 2023-04-01
WO2023009700A3 (en) 2023-04-13
EP4377355A2 (en) 2024-06-05
EP4377355A4 (en) 2025-06-18
CO2024001484A2 (es) 2024-02-26
US20240374721A1 (en) 2024-11-14
MX2024001364A (es) 2024-02-27
AU2022316980A1 (en) 2024-01-25

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