KR20240033237A - 류신이 풍부한 반복 키나아제 2(LRRK2) iRNA 제제 조성물 및 이의 사용 방법 - Google Patents

류신이 풍부한 반복 키나아제 2(LRRK2) iRNA 제제 조성물 및 이의 사용 방법 Download PDF

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KR20240033237A
KR20240033237A KR1020247003234A KR20247003234A KR20240033237A KR 20240033237 A KR20240033237 A KR 20240033237A KR 1020247003234 A KR1020247003234 A KR 1020247003234A KR 20247003234 A KR20247003234 A KR 20247003234A KR 20240033237 A KR20240033237 A KR 20240033237A
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nucleotides
dsrna
nucleotide
strand
antisense strand
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란 티 호앙 당
제임스 디. 매키닌치
마크 케이. 슐러겔
아담 카스토레노
투옌 엠. 응우옌
조세프 배리
매튜 스트리코스
사라 레블랑
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알닐람 파마슈티칼스 인코포레이티드
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KR1020247003234A 2021-06-29 2022-06-29 류신이 풍부한 반복 키나아제 2(LRRK2) iRNA 제제 조성물 및 이의 사용 방법 Pending KR20240033237A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163216119P 2021-06-29 2021-06-29
US63/216,119 2021-06-29
US202263353953P 2022-06-21 2022-06-21
US63/353,953 2022-06-21
PCT/US2022/035561 WO2023278607A1 (en) 2021-06-29 2022-06-29 Leucine-rich repeat kinase 2 (lrrk2) irna agent compositions and methods of use thereof

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US (1) US20240301426A1 (https=)
EP (1) EP4363588A1 (https=)
JP (1) JP2024528503A (https=)
KR (1) KR20240033237A (https=)
AU (1) AU2022303358A1 (https=)
BR (1) BR112023027446A2 (https=)
CA (1) CA3225740A1 (https=)
CL (3) CL2023003984A1 (https=)
CO (1) CO2023018579A2 (https=)
IL (1) IL309548A (https=)
MX (1) MX2024000065A (https=)
TW (1) TW202317149A (https=)
WO (1) WO2023278607A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024238385A2 (en) * 2023-05-12 2024-11-21 Alnylam Pharmaceuticals, Inc. Single-stranded loop oligonucleotides
CN121712891A (zh) * 2023-06-20 2026-03-20 阿达尔克斯制药有限公司 Lrrk2调节组合物及其使用方法
AU2024353921A1 (en) 2023-09-27 2026-04-16 Neuro3 Therapeutics (Suzhou) Ltd. Novel sirna constructs, therapeutics, and modifications
CN120082552A (zh) * 2023-12-01 2025-06-03 艾码生物科技(南京)有限公司 初级-miRNA及其应用

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WO2014110205A1 (en) * 2013-01-11 2014-07-17 Children's Medical Center Corporation Methods and compositions for the production of sirnas
TWI833770B (zh) * 2018-06-27 2024-03-01 美商Ionis製藥公司 用於減少 lrrk2 表現之化合物及方法

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CL2025000168A1 (es) 2025-05-30
JP2024528503A (ja) 2024-07-30
WO2023278607A1 (en) 2023-01-05
MX2024000065A (es) 2024-02-23
CL2025003326A1 (es) 2026-02-20
IL309548A (en) 2024-02-01
TW202317149A (zh) 2023-05-01
AU2022303358A1 (en) 2024-01-18
BR112023027446A2 (pt) 2024-03-12
CL2023003984A1 (es) 2024-08-16
EP4363588A1 (en) 2024-05-08
CA3225740A1 (en) 2023-01-05
US20240301426A1 (en) 2024-09-12
CO2023018579A2 (es) 2024-01-15

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