KR20240019063A - 펜알킬아민 및 이의 제조 및 사용 방법 - Google Patents

펜알킬아민 및 이의 제조 및 사용 방법 Download PDF

Info

Publication number
KR20240019063A
KR20240019063A KR1020237034789A KR20237034789A KR20240019063A KR 20240019063 A KR20240019063 A KR 20240019063A KR 1020237034789 A KR1020237034789 A KR 1020237034789A KR 20237034789 A KR20237034789 A KR 20237034789A KR 20240019063 A KR20240019063 A KR 20240019063A
Authority
KR
South Korea
Prior art keywords
mmol
alkyl
hydrogen
dimethoxy
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020237034789A
Other languages
English (en)
Korean (ko)
Inventor
앤드류 캐리 크뤼겔
Original Assignee
길가메쉬 파마슈티컬스, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 길가메쉬 파마슈티컬스, 인코포레이티드 filed Critical 길가메쉬 파마슈티컬스, 인코포레이티드
Publication of KR20240019063A publication Critical patent/KR20240019063A/ko
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/145Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/49Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58Radicals substituted by nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020237034789A 2021-03-12 2022-03-14 펜알킬아민 및 이의 제조 및 사용 방법 Pending KR20240019063A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163160292P 2021-03-12 2021-03-12
US63/160,292 2021-03-12
PCT/US2022/020196 WO2022192781A1 (en) 2021-03-12 2022-03-14 Phenalkylamines and methods of making and using the same

Publications (1)

Publication Number Publication Date
KR20240019063A true KR20240019063A (ko) 2024-02-14

Family

ID=80999639

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237034789A Pending KR20240019063A (ko) 2021-03-12 2022-03-14 펜알킬아민 및 이의 제조 및 사용 방법

Country Status (11)

Country Link
US (1) US20240166618A1 (https=)
EP (1) EP4305019A1 (https=)
JP (1) JP7849377B2 (https=)
KR (1) KR20240019063A (https=)
CN (1) CN117642379A (https=)
AU (1) AU2022234444A1 (https=)
BR (1) BR112023018237A2 (https=)
CA (1) CA3213289A1 (https=)
IL (1) IL305834A (https=)
MX (1) MX2023010711A (https=)
WO (1) WO2022192781A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4460489A4 (en) * 2022-01-04 2026-04-08 Bright Minds Biosciences Inc PHENETHYLAMINES AND THEIR PREPARATION PROCESSES
WO2023205116A1 (en) * 2022-04-19 2023-10-26 Gilgamesh Pharmaceuticals, Inc. Pyridine derivatives for treating psychiatric disorders
AR130467A1 (es) * 2022-09-12 2024-12-11 Gilgamesh Pharmaceuticals Inc Fenalquilaminas y métodos para fabricar y usar las mismas
WO2025085701A1 (en) * 2023-10-18 2025-04-24 Gilgamesh Pharmaceuticals, Inc. Pyridine derivatives for treating psychiatric disorders
CN119827467B (zh) * 2025-01-10 2026-03-24 中国科学技术大学 酰亚胺类化合物用于阿片类毒品的光激活荧光检测方法
CN120271454B (zh) * 2025-04-01 2026-01-06 衢州凯沃化工有限公司 一种光催化合成含七氟异丙基取代的苯胺化合物的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1643310A1 (de) * 1966-12-29 1971-06-03 Dow Chemical Co 4-Alkyl-2,5-dimethoxy-alpha-methyl-phenaethylamin und seine pharmakologisch vertraeglichen Salze
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma

Also Published As

Publication number Publication date
CA3213289A1 (en) 2022-09-15
JP2024512425A (ja) 2024-03-19
BR112023018237A2 (pt) 2023-11-28
MX2023010711A (es) 2023-11-10
WO2022192781A1 (en) 2022-09-15
EP4305019A1 (en) 2024-01-17
JP7849377B2 (ja) 2026-04-21
CN117642379A (zh) 2024-03-01
AU2022234444A1 (en) 2023-09-28
IL305834A (en) 2023-11-01
US20240166618A1 (en) 2024-05-23

Similar Documents

Publication Publication Date Title
KR20240019063A (ko) 펜알킬아민 및 이의 제조 및 사용 방법
EP3697759B1 (en) MUSCARINIC ACETYLCHOLINE RECEPTOR M4 ANTAGONISTS
CN114945566A (zh) 作为钠通道调节剂的取代四氢呋喃
US20240368151A1 (en) Novel ergolines and methods of treating mood disorders
CN109496213B (zh) 螺环化合物及其制备和使用方法
WO2017087858A1 (en) Pyrazole compounds and methods of making and using same
US20230116703A1 (en) Novel ergolines and methods of treating mood disorders
KR20240128059A (ko) 화합물
CN111032034A (zh) 螺环化合物及其制造和使用方法
JP2015529238A (ja) 新規二環式ピリジノン
US12428373B2 (en) Dopamine D2 receptor ligands
EP3697781B1 (en) Antagonists of the muscarinic acetylcholine receptor m4
TW201718550A (zh) 煙麯黴醇(fumagillol)雜環化合物及其製造及使用方法
TWI743088B (zh) 作爲免疫調節劑的三並環化合物
JP2019023225A (ja) ヘテロアリール化合物及びその使用方法
WO2022261427A1 (en) (4-(6-((2-octahydrocyclopenta[c]pyrrol-5-yl)amino)pyridazin-3-yl)phenyl)(imino)(methyl)-lambda6- sulfanone derivatives and similar compounds as muscarinic acetylcholine receptor m4 antagonists for the treatment of neurodegenerative disorders
JP7716494B2 (ja) Kv1.3カリウムシェーカーチャネル遮断剤としてのアリール複素環化合物
TW202340207A (zh) Klf2誘導劑及其使用方法
US12428380B2 (en) Compounds
KR20260053507A (ko) 화합물
KR20260053282A (ko) 정신 질환의 치료를 위한 피롤로피리딘 화합물
CN107200725B (zh) 稠杂环类衍生物、其制备方法及其在医药上的应用
WO2026060256A1 (en) Sting inhibitors and uses thereof
CN120787225A (zh) 新型麦角林类和治疗心境障碍的方法
HK40004417B (zh) 螺环化合物及其制备和使用方法

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20231011

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20250312

Comment text: Request for Examination of Application