CN117642379A - 苯烷基胺及其制备和使用方法 - Google Patents

苯烷基胺及其制备和使用方法 Download PDF

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Publication number
CN117642379A
CN117642379A CN202280034218.1A CN202280034218A CN117642379A CN 117642379 A CN117642379 A CN 117642379A CN 202280034218 A CN202280034218 A CN 202280034218A CN 117642379 A CN117642379 A CN 117642379A
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China
Prior art keywords
hydrogen
compound
dimethoxy
mixture
alkyl
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Pending
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CN202280034218.1A
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English (en)
Chinese (zh)
Inventor
A·C·克鲁格尔
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Gilgamesh Pharmaceuticals Inc
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Gilgamesh Pharmaceuticals Inc
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Publication of CN117642379A publication Critical patent/CN117642379A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202280034218.1A 2021-03-12 2022-03-14 苯烷基胺及其制备和使用方法 Pending CN117642379A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163160292P 2021-03-12 2021-03-12
US63/160292 2021-03-12
PCT/US2022/020196 WO2022192781A1 (en) 2021-03-12 2022-03-14 Phenalkylamines and methods of making and using the same

Publications (1)

Publication Number Publication Date
CN117642379A true CN117642379A (zh) 2024-03-01

Family

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CN202280034218.1A Pending CN117642379A (zh) 2021-03-12 2022-03-14 苯烷基胺及其制备和使用方法

Country Status (11)

Country Link
US (1) US20240166618A1 (https=)
EP (1) EP4305019A1 (https=)
JP (1) JP7849377B2 (https=)
KR (1) KR20240019063A (https=)
CN (1) CN117642379A (https=)
AU (1) AU2022234444A1 (https=)
BR (1) BR112023018237A2 (https=)
CA (1) CA3213289A1 (https=)
IL (1) IL305834A (https=)
MX (1) MX2023010711A (https=)
WO (1) WO2022192781A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120271454A (zh) * 2025-04-01 2025-07-08 衢州凯沃化工有限公司 一种光催化合成含七氟异丙基取代的苯胺化合物的方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4460489A4 (en) * 2022-01-04 2026-04-08 Bright Minds Biosciences Inc PHENETHYLAMINES AND THEIR PREPARATION PROCESSES
WO2023205116A1 (en) * 2022-04-19 2023-10-26 Gilgamesh Pharmaceuticals, Inc. Pyridine derivatives for treating psychiatric disorders
AR130467A1 (es) * 2022-09-12 2024-12-11 Gilgamesh Pharmaceuticals Inc Fenalquilaminas y métodos para fabricar y usar las mismas
WO2025085701A1 (en) * 2023-10-18 2025-04-24 Gilgamesh Pharmaceuticals, Inc. Pyridine derivatives for treating psychiatric disorders
CN119827467B (zh) * 2025-01-10 2026-03-24 中国科学技术大学 酰亚胺类化合物用于阿片类毒品的光激活荧光检测方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007038372A1 (en) * 2005-09-23 2007-04-05 Alcon, Inc. Phenylethylamine analogs and their use for treating glaucoma

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1643310A1 (de) * 1966-12-29 1971-06-03 Dow Chemical Co 4-Alkyl-2,5-dimethoxy-alpha-methyl-phenaethylamin und seine pharmakologisch vertraeglichen Salze

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007038372A1 (en) * 2005-09-23 2007-04-05 Alcon, Inc. Phenylethylamine analogs and their use for treating glaucoma

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CLARE, BW: "STRUCTURE ACTIVITY CORRELATIONS FOR PSYCHOTOMIMETICS .2. PHENYLALKYLAMINES - A TREATMENT OF NONLINEARITY USING THE ALTERNATING CONDITIONAL EXPECTATIONS TECHNIQUE", 《CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS》, vol. 18, no. 1, 1 January 1993 (1993-01-01), pages 71 - 92 *
DANIEL TRACHSEL: "Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur–Aktivitätsbeziehungen. Mitteilung 2:4-Thio-substituierte [2-(2, 5-Dimethoxyphenyl)ethyl]amine (=2, 5-Dimethoxybenzolethanamine)", 《HELVETICA CHIMICA ACTA》, vol. 86, no. 7, 5 August 2003 (2003-08-05), pages 2613 *
DOWD, CS 等: "1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT2A Partial Agonists", 《JOURNAL OF MEDICINAL CHEMISTRY》, vol. 43, no. 16, 14 July 2000 (2000-07-14), pages 3074 - 3084, XP002412620, DOI: 10.1021/jm9906062 *
HANSEN, MARTIN 等: "Synthesis and Structure−Activity Relationships of N‑Benzyl Phenethylamines as 5‑HT2A/2C Agonists", 《 ACS CHEMICAL NEUROSCIENCE》, vol. 5, no. 3, 7 January 2014 (2014-01-07), pages 5 *
JENSEN, AA 等: "Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2, 5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2A Receptor Agonist", 《JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS》, vol. 361, no. 3, 1 June 2017 (2017-06-01), pages 1 *
RICHARD A. GLENNON 等: "Binding of Phenylalkylamine Derivatives at 5-HT1C and 5-HT2 Serotonin Receptors: Evidence for a Lack of Selectivity", 《JOURNAL OF MEDICINAL CHEMISTRY》, vol. 35, no. 4, 1 February 1992 (1992-02-01), pages 737, XP055045196, DOI: 10.1021/jm00082a014 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120271454A (zh) * 2025-04-01 2025-07-08 衢州凯沃化工有限公司 一种光催化合成含七氟异丙基取代的苯胺化合物的方法
CN120271454B (zh) * 2025-04-01 2026-01-06 衢州凯沃化工有限公司 一种光催化合成含七氟异丙基取代的苯胺化合物的方法

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CA3213289A1 (en) 2022-09-15
JP2024512425A (ja) 2024-03-19
BR112023018237A2 (pt) 2023-11-28
MX2023010711A (es) 2023-11-10
WO2022192781A1 (en) 2022-09-15
EP4305019A1 (en) 2024-01-17
JP7849377B2 (ja) 2026-04-21
AU2022234444A1 (en) 2023-09-28
IL305834A (en) 2023-11-01
KR20240019063A (ko) 2024-02-14
US20240166618A1 (en) 2024-05-23

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