KR20230168005A - Red Ginseng Tablet And Preparing Method Thereof - Google Patents

Abstract

The present invention provides red ginseng tablets containing red ginseng powder and red ginseng oil. The tablet according to the present invention contains a high content of red ginseng powder and a predetermined amount of red ginseng oil, so that although it does not use lubricants such as sucrose fatty acid ester and glycerin fatty acid ester, it is compared with tablets using a lubricant. Therefore, the tableting properties are similar or better. Since these red ginseng tablets do not contain a lubricant and contain a high content of red ginseng-derived ingredients, the effect of enhancing physiological activity according to the red ginseng-derived ingredients can be maximized, and the daily intake required to achieve a certain index ingredient content is small. This has the advantage of lowering the burden on consumers.

Description

Red Ginseng Tablet And Preparing Method Thereof}

The present invention relates to red ginseng tablets containing no lubricant and a method for producing the same.

Ginseng (Panax ginseng C.A. Meyer) is a perennial herb belonging to the genus Panax of the Araliaceae family. It is one of the herbal medicines used in oriental medicine. It has a sweet and bitter taste, has a warm energy, restores vitality and protects the spleen, and It has herbal benefits such as strengthening the lungs.

The main physiologically active substances in ginseng include saponins, also called ginsenosides, essential oil components, polyacetylene, phenolic components, glycosides, and acid peptides. In addition, it contains various components such as vitamins, sugars, and minerals. The general physiological effects of ginseng have been reported to include central nervous system activity, immune function strengthening, and anti-cancer activity. In particular, about 40 types of ginsenosides have been discovered so far, and it has been confirmed that they have a wide range of effects on the central nervous system, endocrine system, immune system, and metabolic system, showing an excellent effect in regulating physical functions, that is, normalizing physiological functions. These ginsenosides may have similar or opposing effects, and it is known that certain ingredients exert various effects alone or through interactions of several types.

Among the nutrients in ginseng, the fat-soluble component content is about 1-2%. Research on the chemical composition and physiological activity of ginseng oil is still insufficient, but according to recent studies, red ginseng oil has specific ingredient characteristics that are differentiated from other existing vegetable oils and is evaluated to have excellent physiological activity. Therefore, research is continuously being conducted to utilize it in cosmetic compositions or health functional food compositions (Patent Document 1).

Until now, it has been common for oriental herbal products, including ginseng, to be consumed in the form of liquid extracts or decoctions, but recently, for various reasons such as making it easier to consume herbal functional ingredients or giving the pleasure of eating through new textures, Research is being actively conducted on various dosage forms such as tablets, pills, capsules, and jelly types (Patent Document 2).

As part of such formulation research, the present inventor was conducting research on red ginseng tablets that mainly contain ginseng-derived ingredients and do not contain a lubricant, and found that if a certain amount of red ginseng oil is used when manufacturing tablets, the tablets can be used without using a lubricant. It was confirmed that tablets of good quality could be manufactured. Accordingly, research continued on the tablet manufacturing method using red ginseng oil and the present invention was completed.

Republic of Korea Patent Publication No. 10-1440675 Republic of Korea Patent Publication No. 10-0836446

The purpose of the present invention is to provide red ginseng tablets with good tableting properties without using a lubricant and a method for producing the same.

One aspect of the present invention provides a red ginseng tablet containing red ginseng powder and red ginseng oil.

Another aspect of the present invention includes adding and mixing red ginseng oil dispersed in alcohol to red ginseng powder; And providing a method for producing red ginseng tablets comprising the step of compressing the mixture into tablets.

The tablet according to the present invention contains a high content of red ginseng powder and a predetermined amount of red ginseng oil, so that although it does not use lubricants such as sucrose fatty acid ester and glycerin fatty acid ester, it is compared with tablets using a lubricant. Therefore, the tableting properties are similar or better.

Since these red ginseng tablets do not contain a lubricant and contain a high content of red ginseng-derived ingredients, the effect of enhancing physiological activity according to the red ginseng-derived ingredients can be maximized, and the daily intake required to achieve a certain index ingredient content is small. This has the advantage of lowering the burden on consumers.

Figure 1 is a photograph of the appearance of tablets manufactured according to Examples and Comparative Examples of the present invention.

Hereinafter, the present invention will be described in more detail to facilitate understanding of the present invention.

Terms or words used in this specification and claims should not be construed as limited to their usual or dictionary meanings, and the inventor may appropriately define the concept of terms in order to explain his or her invention in the best way. It must be interpreted with meaning and concept consistent with the technical idea of the present invention based on the principle that it is.

1. Red ginseng tablets

The present invention provides red ginseng tablets containing red ginseng powder and red ginseng oil.

In the present invention, the term "tablet" refers to a product formed by pressurizing and compressing powder into a certain shape to make it easy for users to take. The powder refers to an aggregate of solid materials that form a tablet, and the particle size of the powder may be in the range of about 1-100㎛, but is not limited thereto. The shape of the powder may vary, for example, the powder may be scaly, angular, crystalline, dentritic, fibrous, flaky, granular ( It can be formed in granular, irregular, or spherical shapes.

The tablet may be an uncoated tablet or a coated tablet coated with a coating agent. The coating agent may be used without limitation and may be, for example, neocoat.

The red ginseng is obtained by steaming ginseng, and the ginseng can be used without limitation, such as cultivated or commercially available. The ginseng includes various processed products, for example, at least one selected from the group consisting of fresh ginseng, uncooked ginseng, black ginseng, wild ginseng, camphor ginseng, wild ginseng, purified ginseng, enzyme-treated unprocessed ginseng, fermented ginseng, red ginseng, and fermented red ginseng. It may be one, but is not limited to this. Fresh ginseng refers to raw ginseng that has maintained its original form, and uncooked ginseng refers to the thin roots of ginseng. Red ginseng is made by steaming, cooking, and drying raw ginseng. During the drying process, a browning reaction occurs, giving it a light yellow-brown to reddish-brown color. Black ginseng refers to ginseng that has turned black by steaming and drying red ginseng several times. Wild ginseng refers to native ginseng, and camphor ginseng refers to wild ginseng that has been planted and grown. Wild ginseng is ginseng grown artificially by sowing and transplanting seeds or seedlings of ginseng in mountainous forests.

The red ginseng powder is used to include both red ginseng powder obtained by mechanically pulverizing red ginseng and red ginseng concentrate powder obtained by concentrating and/or drying the red ginseng extract.

The average particle diameter of red ginseng powder used to manufacture tablets may be 100㎛ to 125㎛, or 100㎛ to 120㎛, but is not limited thereto. In addition, in order to obtain a particle size suitable for tableting, the red ginseng powder was subjected to a granulation process to produce granules having an average particle size of 210㎛ to 2㎜, or 297㎛ to 1㎜, or 595㎛ to 840㎛, or 297㎛ to 595㎛. After forming, it can be used for tableting. If the size of the red ginseng powder is less than the lower limit, flow problems may occur during tableting, a capping phenomenon in which the top of the tablet peels off from the body, and a laminating phenomenon in which the tablet is split horizontally to form stripes or peel off in layers may occur. If the red ginseng powder exceeds the upper limit, tablets with a uniform surface may not be obtained. However, the particle size of the ginseng powder used may vary depending on the raw material composition and characteristics of the tablet to be manufactured.

When pulverizing red ginseng to obtain pulverized red ginseng powder, pulverization may be performed in a conventional manner and is not particularly limited. Grinding may be performed more than once.

In the present invention, extract refers to a substance extracted from red ginseng by any method, and is used to include all of the extract thus extracted, the concentrate obtained therefrom, and the dried product and powder of the concentrate.

In the present invention, red ginseng extract can be obtained by extracting red ginseng or its dried product. When obtaining an extract from red ginseng, the red ginseng extract may be obtained from red ginseng in a conventional manner. For example, all conventionally known extraction methods such as solvent extraction, ultrasonic extraction, filtration, and reflux extraction can be used. Preferably, it can be prepared by using solvent extraction or reflux extraction. The extraction process can be repeated several times, and then additional steps such as concentration or freeze-drying can be performed.

When obtaining an extract from the red ginseng, at least one selected from the group consisting of water, organic solvent, supercritical fluid, and mixtures thereof can be used as an extraction solvent. The organic solvent is alcohol, preferably lower alcohol of C ₁ -C ₄ , hexane (n-hexane), ether, glycerol, propylene glycol, butylene glycol, ethyl acetate, methyl acetate, dichloromethane, chloroform, ethyl acetate, It may be any one selected from the group consisting of benzene and mixed solvents thereof. Extraction may be performed at 40°C to 120°C, preferably at 40°C to 100°C, and more preferably at 50°C to 90°C, but is not limited thereto. Extraction can be performed for 4 to 36 hours, preferably 8 to 24 hours. Extraction may be performed 3 to 12 times, but is not limited to this.

The red ginseng powder is 70 to 99.5% by weight, or 75 to 99.5% by weight, or 80 to 99.5% by weight, or 85 to 99.5% by weight, or 90 to 99.5% by weight, or 95 to 99.5% by weight, based on the total weight of the red ginseng tablet. It may be included in weight percent, or 98 to 99.5 weight percent, or 98.5 to 99.3 weight percent. If the above numerical range is exceeded, capping, laminating, and tablets may adhere to the punch, which may lower the tableting properties. If the numerical range is below the above numerical range, the tableting properties may improve, but the content of other excipients increases, which lowers consumer preference. There is.

In the present invention, red ginseng oil is oil extracted from red ginseng or red ginseng peel by any method.

In the present invention, red ginseng meal refers to a by-product generated after extracting and using red ginseng obtained by steaming and/or drying ginseng with water, organic solvent, etc., and may include a red ginseng meal powder formulation. The red ginseng powder can be obtained in powder form by washing the red ginseng powder with water and then drying it with hot air.

In the present invention, red ginseng oil can be obtained by separating and extracting the fat-soluble components contained in red ginseng or red ginseng peel through supercritical fluid extraction. Supercritical fluid extraction is an extraction method using a supercritical fluid that appears when the temperature and pressure exceed a certain critical point. The liquid has high dissolving power, rapid material movement and heat transfer, low viscosity, and rapid penetration into micropores due to a high diffusion coefficient. It is an extraction method that combines the advantages of gas and gas. In general, supercritical fluids have the property of changing solubility and density depending on changes in temperature and pressure, so the activity of the extract may vary accordingly. In this way, the extraction method using supercritical fluid allows setting conditions in a high-density state by manipulating pressure and temperature, so it has excellent selectivity for fractionation and separation, allowing high-purity natural active ingredients to be obtained, and can be extracted at a relatively low temperature. Therefore, it has the advantage of preventing loss of natural active ingredients due to heat.

In the present invention, carbon dioxide, which has a critical point close to room temperature, is non-toxic and non-flammable, and is very inexpensive, can be used as the supercritical fluid. During supercritical extraction, conditions such as temperature, time, and pressure can be adjusted as needed, and the conditions are explained in detail below.

The temperature during extraction with supercritical fluid may be 40°C to 100°C, preferably 50°C to 90°C, and more preferably 60°C to 80°C, but is not limited thereto. If the temperature during extraction is outside the appropriate range, the yield of the extract decreases, production costs increase, and the cost of the product increases.

When extracting with a supercritical fluid, the extraction time may be 0.5 hours to 10 hours, preferably 1 hour to 9 hours, and more preferably 2 hours to 8 hours or 2 hours to 5 hours. It is not limited.

The red ginseng oil may be included in an amount of 0.1 to 5% by weight, or 0.3 to 5% by weight, or 0.5 to 5% by weight, or 0.5 to 2% by weight, or 0.7 to 1.5% by weight, based on the total weight of the red ginseng tablet. If it exceeds the above numerical range, there may be a problem with the formation of granules for tableting, and if it is below the above numerical range, capping, laminating, and tablet adhesion to the punch may occur, which may lower tableting properties.

The red ginseng tablet of the present invention may contain substantially no lubricant by using red ginseng oil together with red ginseng powder. The lubricant includes talc, stearic acid and its salts, sucrose fatty acid ester, glycerin fatty acid ester, sodium lauryl sulfate, hydrogenated vegetable oil, sodium benzoate, sodium stearyl fumarate, glyceryl monostearate, polyethylene glycol, carnauba wax, and It may be a mixture of these, for example, sucrose fatty acid ester or glycerin fatty acid ester, but is not limited thereto. The tablet of the present invention may not contain the ingredients listed above as a lubricant, but if the ingredients are used as additives commonly used in the manufacture of tablets such as excipients, lubricants, and binders, the ingredients may also be included in the tablet of the present invention. may be included in

The term “substantially containing no lubricant” includes including the lubricant in the tablet in a smaller amount than the amount typically used for the purpose of improving the tabletting properties of the tablet. Additionally, the tablet of the present invention may not contain the above lubricant at all or may contain the lubricant in an amount that is not detected/measured through conventional detection/measurement methods.

The tablet of the present invention contains no commonly used lubricant ingredients at all or contains less than the usual amount of lubricant, but has the characteristic of being able to exhibit tableting properties similar to or better than red ginseng tablets using a lubricant ingredient. , it has the advantage of being able to significantly increase the content of red ginseng-derived ingredients, which are active ingredients, while exhibiting sufficient tableting properties.

In addition, the red ginseng tablet may additionally contain additional ingredients such as other functional substances, excipients, binders, diluents, disintegrants, adsorbents, moisturizers, film coating agents, and plasticizers, as needed.

The other functional substances include kudzu root extract, licorice extract, dried ginger extract, cinnamon extract, cinnamon extract, goji berry extract, antler extract, deer antler extract, angelica root extract, jujube extract, eucalyptus extract, maekmundong extract, bokryeong extract, peony extract, and baekchul extract. , Bokbunja extract, Sasangja extract, Cornus officinalis extract, Sanghwang mushroom extract, Ginger extract, Seokchangpo extract, Rehmannia glutinosa extract, Ganoderma lucidum extract, Acanthopanax extract, Schisandra chinensis extract, Hyssop extract, Fungi mushroom extract, Yin Yang Gwak extract, Uiiin extract, Clove extract, Bamboo leaf extract, dermis extract, chaga mushroom extract, Cheongung extract, Safflower extract, Astragalus extract, Hwangjeong extract, Rehmannia glutinosa extract, jujube extract, Mountain Lion extract, Yuk Jong-yong extract, Baeksu-o extract, Tosa-ja extract, Baeamchazugi extract, Luohan fruit It may include one or more selected from the group consisting of extracts and combinations thereof.

The excipient may include one or more selected from the group consisting of lactose, starch, white sugar, glucose, dextrin, mannitol, sorbitol, inorganic salt, and cellulose.

The binder may be starch paste, sugar syrup, gelatin, CMC sodium (CMC-Na), gum arabic, polyvinylpyrrolidone (PVP), copovidone, macrogol, hydroxypropylcellulose or hydroxypropyl methylcellulose (HPMC). Cellulose derivatives such as; Silicate derivatives such as light anhydrous silicic acid, synthetic aluminum silicate, calcium silicate or magnesium metasilicate aluminate; and phosphates such as calcium hydrogen phosphate; It may include one or more types selected from the group consisting of carbonates such as calcium carbonate.

The diluent is selected from the group consisting of calcium carbonate, calcium phosphate, dextrin, dextrose, fructose, glyceryl palmitostearate, sucrose, lactose, glucose, mannitol, alkaline earth metal salt, clay, polyethylene glycol, and dicalcium phosphate. It may include one or more selected types.

The disintegrant may include at least one selected from the group consisting of croscarmellose, sodium starch glycolate, CMC-Ca, crospovidone, and alginic acid. You can.

The adsorbent may include one or more selected from the group consisting of colloidal silica, powdered cellulose, and activated charcoal.

The moisturizing agent may include one or more selected from the group consisting of glycerin, propylene glycol, and sorbitol.

The film coating agent includes gelatin, polyethylene glycol, shellac, polyvinyl alcohol, polyvinylpyrrolidone, polymer of vinylpyrrolidone and vinyl acetate, ethyl acrylate methacrylate methyl methacrylate trimethylammonium ethyl chloride copolymer (e.g., brand name Selected from the group consisting of Eudragit RS or RL, Degussa), methyl methacrylate ethyl acrylate copolymer (e.g. Eudragit NE30D, Degussa), and polyvinylacetyldimethylaminoacetate It may include one or more types.

The plasticizer may include one or more selected from the group consisting of glycol, ester, oil, glycerin, and glycerin derivatives, of which glycol may be propylene glycol, polyethylene glycol, or a mixture thereof, and ester may be phthalic acid. It may be diethyl, dibutyl phthalate, dibutyl sebacate, triethyl citrate, acetyltriethyl citrate, acetyltributyl citrate, triacetin, or mixtures thereof.

The additional ingredients may be included in an amount of 0.2 to 25% by weight, or 0.2 to 20% by weight, or 0.4 to 15% by weight, or 0.4 to 10% by weight, or 0.4 to 5% by weight, based on the total weight of the red ginseng tablet. . When the above numerical range is met, tabletting properties are good and the appearance or palatability of the tablet can be improved.

The hardness of the red ginseng tablet of the present invention may be 5 to 30 kp, or 10 to 20 kp, or 10 to 15 kp.

2. Manufacturing method of red ginseng tablets

One aspect of the present invention provides a method for producing red ginseng tablets, comprising adding and mixing red ginseng oil dispersed in alcohol to red ginseng powder.

The alcohol as an organic solvent for dispersing the red ginseng oil may be alcohol or an alcohol aqueous solution, and the alcohol may be at least one selected from the group consisting of C ₁ -C ₄ lower alcohols and mixtures thereof, preferably It may be ethanol or an aqueous ethanol solution.

The method of the present invention may further include forming granules from the mixture. The step of forming the granules may be performed by dry granulation, wet granulation, etc. Specifically, when granulating with dry granules, the mixture containing red ginseng powder and red ginseng oil is compressed and sieved using a roller compactor, and other ingredients are added and mixed as necessary, and then tableted. You can. In the case of direct compression without granulation, each component can be mixed and compressed directly.

The present invention includes the step of compressing the mixture or granule. The tableting may be performed using any tablet press known to those skilled in the art, for example, tableting may be performed with a compression force of 1 to 30 kN, 2 to 30 kN, 2 to 15 kN, or 3 to 15 kN. You can. For example, it can be performed using rotary tableting equipment such as GRC-15S (Sejong), (KTMD, KTMSA, KTSA, KTSS Series (Keumseong Sangi), etc.

Since the same contents as described above can be applied to the red ginseng powder and red ginseng oil, detailed description is omitted here.

Hereinafter, the present invention will be described in detail through preparation examples and examples.

However, the following preparation examples and examples are only for illustrating the present invention, and the content of the present invention is not limited by the following preparation examples and examples.

Example

Preparation Example 1 - Red ginseng powder

10 times the amount of purified water was added to 10kg of red ginseng and extracted at 90±5°C for over 24 hours. The extract was centrifuged and concentrated to prepare red ginseng concentrate, which was then dried using a spray dryer and powdered.

Preparation Example 2 - Red ginseng oil

Red ginseng or red ginseng from which water-soluble components were removed was dried and pulverized and then extracted by placing it in a supercritical extraction device. The extracted red ginseng oil was filtered and purified using activated carbon, etc.

Example 1 - Red ginseng tablets

300g of red ginseng powder was used as a seed, and 4.5g of red ginseng oil and 45g of ethanol aqueous solution were used as a binder solution, and were mixed and granulated using a fluidized bed granulator (manufacturer GLATT, product name Granulator). The granular powder was then compressed into tablets to prepare tablets with a cross-sectional diameter of approximately 14.51 mm and a thickness of 4.54 mm.

Example 2

Tablets of Example 2 were prepared in the same manner as Example 1, except that the ingredients and mixing ratios were changed as shown in Table 1 below.

Comparative Examples 1 to 4

In Comparative Example 1, a raw material consisting of only 300 g of red ginseng powder was placed in a fluidized bed granulator and mixed and granulated to prepare tablets.

In Comparative Examples 2 to 4, each component of red ginseng oil, sucrose fatty acid ester, or glycerin fatty acid ester was added directly to red ginseng powder in the amounts shown in Table 1, and then mixed and granulated in a fluidized bed granulator to prepare tablets.

Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Red ginseng powder (%) 98.52 99.26 100 98.52 98.52 98.52 Red ginseng oil (%) 1.48 0.74 Sucrose fatty acid ester (%) 1.33 1.48 Glycerin fatty acid ester (%) 0.15 1.48

Experimental Example 1 - Tabletability

In order to evaluate the tableting properties of the red ginseng tablets of Examples and Comparative Examples, the appearance was observed with the naked eye immediately after tableting, and a photograph of the appearance is shown in Figure 1.

From the results shown in FIG. 1, it can be seen that the red ginseng tablet of Example 1 had excellent tableting properties, and the red ginseng tablets of Example 2 had good tableting properties.

On the other hand, the red ginseng tablet of Comparative Example 1 had low tableting properties due to capping, laminating, and tablet adhesion to the punch. In addition, the red ginseng tablets of Comparative Examples 2 to 4 had low tableting properties due to sticking.

Therefore, according to the present invention, it can be seen that tabletting properties are superior to those when using a conventional lubricant at the same mixing ratio, and in addition, since it is composed only of red ginseng-derived ingredients such as red ginseng powder and red ginseng oil, the effect of improving physiological activity is further increased. There is.

Claims (8)

Red ginseng tablets containing red ginseng powder and red ginseng oil. In claim 1,
Based on the total weight of red ginseng tablets,
95 to 99.5% by weight of red ginseng powder; and
Red ginseng tablets containing 0.5 to 5% by weight of red ginseng oil. In claim 1,
A red ginseng tablet further comprising one or more additional ingredients selected from the group consisting of other functional substances, excipients, binders, diluents, disintegrants, adsorbents, moisturizers, film coating agents, and plasticizers. In claim 3,
Based on the total weight of red ginseng tablets,
90-99.5% by weight of red ginseng powder;
Red ginseng oil 0.1~5% by weight; and
Red ginseng tablets containing 0.4 to 5% by weight of additional ingredients. In claim 1,
The red ginseng powder is a red ginseng tablet containing red ginseng concentrate powder and red ginseng ground powder. In claim 1,
The red ginseng tablets include talc, stearic acid and its salts, sucrose fatty acid ester, glycerin fatty acid ester, sodium lauryl sulfate, hydrogenated vegetable oil, sodium benzoate, sodium stearyl fumarate, glyceryl monostearate, polyethylene glycol, carnauba wax, and Red ginseng tablets that do not contain one or more lubricants selected from the group consisting of mixtures thereof. Adding and mixing red ginseng oil dispersed in alcohol to red ginseng powder; and
A method for producing red ginseng tablets comprising: compressing the mixture into tablets. In claim 7,
In the mixing step, 0.5 to 5 parts by weight of red ginseng oil is added to 95 to 99.5 parts by weight of red ginseng powder and mixed.