KR20230162685A - 아실 CoA 화합물 환원 활성을 갖는 재조합 폴리펩티드 - Google Patents
아실 CoA 화합물 환원 활성을 갖는 재조합 폴리펩티드 Download PDFInfo
- Publication number
- KR20230162685A KR20230162685A KR1020237037160A KR20237037160A KR20230162685A KR 20230162685 A KR20230162685 A KR 20230162685A KR 1020237037160 A KR1020237037160 A KR 1020237037160A KR 20237037160 A KR20237037160 A KR 20237037160A KR 20230162685 A KR20230162685 A KR 20230162685A
- Authority
- KR
- South Korea
- Prior art keywords
- amino acid
- substituted
- acid residue
- phenylalanine
- alanine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01024—Succinate-semialdehyde dehydrogenase (NAD+) (1.2.1.24)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01076—Succinate-semialdehyde dehydrogenase (acetylating) (1.2.1.76)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01079—Succinate-semialdehyde dehydrogenase (NADP+) (1.2.1.79)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/145—Clostridium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021057313 | 2021-03-30 | ||
| JPJP-P-2021-057313 | 2021-03-30 | ||
| PCT/JP2022/012463 WO2022209994A1 (ja) | 2021-03-30 | 2022-03-17 | アシルCoA化合物還元活性を有する組換えポリペプチド |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20230162685A true KR20230162685A (ko) | 2023-11-28 |
Family
ID=83456173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237037160A Pending KR20230162685A (ko) | 2021-03-30 | 2022-03-17 | 아실 CoA 화합물 환원 활성을 갖는 재조합 폴리펩티드 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240158764A1 (https=) |
| EP (1) | EP4317438A1 (https=) |
| JP (1) | JPWO2022209994A1 (https=) |
| KR (1) | KR20230162685A (https=) |
| CN (1) | CN117083388A (https=) |
| WO (1) | WO2022209994A1 (https=) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011512868A (ja) | 2008-03-11 | 2011-04-28 | ディーエスエム アイピー アセッツ ビー.ブイ. | アジピン酸(エステルまたはチオエステル)の合成 |
| JP2012188407A (ja) | 2011-03-14 | 2012-10-04 | Mitsubishi Chemicals Corp | 精製ペンタメチレンジアミンの製造方法及びポリアミド樹脂の製造方法 |
| JP2012525856A (ja) | 2009-05-07 | 2012-10-25 | ゲノマチカ, インク. | アジペート、ヘキサメチレンジアミン、及び6−アミノカプロン酸の生合成のための微生物及び方法 |
| JP2016501031A (ja) | 2012-12-21 | 2016-01-18 | エボニック デグサ ゲーエムベーハーEvonik Degussa GmbH | カルボン酸又はジカルボン酸又はそれらのモノエステルからのアミン及びジアミンの製造 |
| JP2016533162A (ja) | 2013-09-17 | 2016-10-27 | ズィモケム インコーポレイテッドZymochem Inc. | 再生可能資源から化合物を生成するための高収量経路 |
| JP2016538870A (ja) | 2013-12-05 | 2016-12-15 | アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー | 脂肪アミンの微生物生産方法 |
| JP2017533734A (ja) | 2014-11-14 | 2017-11-16 | インビスタ テクノロジーズ エス.アー.エール.エル. | 6−炭素モノマーを産生するための方法および材料 |
| JP2018046843A (ja) | 2009-06-04 | 2018-03-29 | ゲノマチカ, インク. | 1,4−ブタンジオールの生成のための微生物体及び関連する方法 |
| WO2019159831A1 (ja) | 2018-02-15 | 2019-08-22 | 国立大学法人神戸大学 | 組換え宿主細胞及びd-ブタントリオールの新規製造方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY153590A (en) * | 2008-12-12 | 2015-02-26 | Celexion Llc | Biological synthesis of difunctional alkanes from alpha ketoacids |
| WO2010126670A2 (en) * | 2009-03-27 | 2010-11-04 | Gojo Industries, Inc. | Compositions and methods for screening and using compounds antagonizing spore-surface interactions |
| CA3297132A1 (en) * | 2014-12-23 | 2026-03-02 | Genomatica, Inc. | Method of producing & processing diamines |
-
2022
- 2022-03-17 EP EP22780213.9A patent/EP4317438A1/en not_active Withdrawn
- 2022-03-17 CN CN202280024848.0A patent/CN117083388A/zh not_active Withdrawn
- 2022-03-17 KR KR1020237037160A patent/KR20230162685A/ko active Pending
- 2022-03-17 US US18/284,538 patent/US20240158764A1/en active Pending
- 2022-03-17 JP JP2023510962A patent/JPWO2022209994A1/ja active Pending
- 2022-03-17 WO PCT/JP2022/012463 patent/WO2022209994A1/ja not_active Ceased
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011512868A (ja) | 2008-03-11 | 2011-04-28 | ディーエスエム アイピー アセッツ ビー.ブイ. | アジピン酸(エステルまたはチオエステル)の合成 |
| JP2012525856A (ja) | 2009-05-07 | 2012-10-25 | ゲノマチカ, インク. | アジペート、ヘキサメチレンジアミン、及び6−アミノカプロン酸の生合成のための微生物及び方法 |
| JP2018046843A (ja) | 2009-06-04 | 2018-03-29 | ゲノマチカ, インク. | 1,4−ブタンジオールの生成のための微生物体及び関連する方法 |
| JP2012188407A (ja) | 2011-03-14 | 2012-10-04 | Mitsubishi Chemicals Corp | 精製ペンタメチレンジアミンの製造方法及びポリアミド樹脂の製造方法 |
| JP2016501031A (ja) | 2012-12-21 | 2016-01-18 | エボニック デグサ ゲーエムベーハーEvonik Degussa GmbH | カルボン酸又はジカルボン酸又はそれらのモノエステルからのアミン及びジアミンの製造 |
| JP2016533162A (ja) | 2013-09-17 | 2016-10-27 | ズィモケム インコーポレイテッドZymochem Inc. | 再生可能資源から化合物を生成するための高収量経路 |
| JP2016538870A (ja) | 2013-12-05 | 2016-12-15 | アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー | 脂肪アミンの微生物生産方法 |
| JP2017533734A (ja) | 2014-11-14 | 2017-11-16 | インビスタ テクノロジーズ エス.アー.エール.エル. | 6−炭素モノマーを産生するための方法および材料 |
| WO2019159831A1 (ja) | 2018-02-15 | 2019-08-22 | 国立大学法人神戸大学 | 組換え宿主細胞及びd-ブタントリオールの新規製造方法 |
Non-Patent Citations (4)
| Title |
|---|
| Cheong, et. al. Energy-and carbon-efficient synthesis of functionalized small molecules in bacteria using non-decarboxylative Claisen condensation reactions, Nature biothechnology, 2016 |
| Turk et. al. Metabolic Engineering toward Sustainable Production of Nylon-6, ACS Synth. Biol. 2016, 5, pp.65-73 |
| Yu Zhou, et. al. Biosynthesis of adipic acid by a highly efficient induction-free system in Escherichia Coli, Journal of Biotechnology, Elsevier, 2020, 8, pp.314-315 |
| Yu, et.al. Direct biosynthesis of adipic acid from a synthetic pathway in recombinant Escherichia coli, Biotechinology and Bioengineering, Wiley Periodicals, Inc., 2014, vol.111, pp.2580. |
Also Published As
| Publication number | Publication date |
|---|---|
| US20240158764A1 (en) | 2024-05-16 |
| EP4317438A1 (en) | 2024-02-07 |
| CN117083388A (zh) | 2023-11-17 |
| JPWO2022209994A1 (https=) | 2022-10-06 |
| WO2022209994A1 (ja) | 2022-10-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Maier et al. | Molecular characterization of the 56-kDa CYP153 from Acinetobacter sp. EB104 | |
| JP2022023169A (ja) | 1,4-ブタンジオールおよびその前駆体の生合成のための組成物および方法 | |
| Chen et al. | Identification of an itaconic acid degrading pathway in itaconic acid producing Aspergillus terreus | |
| JP2015142577A (ja) | 3−ヒドロキシアルカン酸の酵素的脱炭酸によるアルケンの製造法 | |
| JP2014506466A (ja) | イソ酪酸を製造するための細胞及び方法 | |
| Liang et al. | Production of 3-hydroxypropionate using a novel malonyl-CoA-mediated biosynthetic pathway in genetically engineered E. coli strain | |
| CN113151201B (zh) | 高热稳定性高活性异丁香酚单加氧酶突变体及其应用 | |
| KR20150022889A (ko) | 생합성 경로, 재조합 세포 및 방법 | |
| Fedorchuk et al. | Site-directed mutagenesis and stability of the carboxylic acid reductase MAB4714 from Mycobacterium abscessus | |
| US20220348974A1 (en) | Biotin synthases for efficient production of biotin | |
| EP3090043A1 (en) | 3-hydroxyisovalerate (hiv) synthase variants | |
| US10227617B2 (en) | Sequestration of carbon dioxide with hydrogen to useful products | |
| US20240228986A1 (en) | Engineered cells, enzymes, and methods for producing cannabinoids | |
| KR20230162685A (ko) | 아실 CoA 화합물 환원 활성을 갖는 재조합 폴리펩티드 | |
| CN110607335B (zh) | 一种烟酰胺腺嘌呤二核苷酸类化合物生物合成方法 | |
| CN112368378B (zh) | 3-甲基巴豆酸脱羧酶(mdc)变体 | |
| US20250019671A1 (en) | Recombinant polypeptide having carboxylic acid reducing activity | |
| Zhou et al. | Exploring, cloning, and characterization of aryl-alcohol dehydrogenase for β-Phenylethanol production in Paocai | |
| Lee et al. | Cloning of srfA operon from Bacillus subtilis C9 and its expression in E. coli | |
| Duan et al. | Cloning, expression, characterization and application of atcA, atcB and atcC from Pseudomonas sp. for the production of l-cysteine | |
| Chung et al. | Cloning, expression, and characterization of P450 monooxygenase CYP102H1 from Nocardia farcinica | |
| CN116286696B (zh) | 一种l-泛解酸内酯脱氢酶及其共表达工程菌在合成d-泛解酸内酯中的应用 | |
| JP2020036576A (ja) | コエンザイムA(CoA)によるフィードバック阻害を受けないパントテン酸キナーゼ | |
| US7901923B2 (en) | Microorganism of Enterobacteriacae genus harboring genes associated with L-carnitine biosynthesis and method of producing L-carnitine using the microorganism | |
| Reshetnikov et al. | Alteration of cofactor specificity of the acrylyl-CoA reductase from Escherichia coli |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| D21 | Rejection of application intended |
Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D21-EXM-PE0902 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |