KR20230160308A - Vmat2 억제제 및 사용 방법 - Google Patents

Vmat2 억제제 및 사용 방법 Download PDF

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Publication number
KR20230160308A
KR20230160308A KR1020237035676A KR20237035676A KR20230160308A KR 20230160308 A KR20230160308 A KR 20230160308A KR 1020237035676 A KR1020237035676 A KR 1020237035676A KR 20237035676 A KR20237035676 A KR 20237035676A KR 20230160308 A KR20230160308 A KR 20230160308A
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KR
South Korea
Prior art keywords
compound
methoxy
dimethylpropyl
isoquinolin
pyrido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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KR1020237035676A
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English (en)
Korean (ko)
Inventor
니콜 해리엇
니콜라스 파가노
바이런 에이. 분
Original Assignee
뉴로크린 바이오사이언시즈 인코퍼레이티드
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Publication of KR20230160308A publication Critical patent/KR20230160308A/ko
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020237035676A 2021-03-22 2022-03-21 Vmat2 억제제 및 사용 방법 Pending KR20230160308A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163164135P 2021-03-22 2021-03-22
US63/164,135 2021-03-22
PCT/US2022/021080 WO2022203984A1 (en) 2021-03-22 2022-03-21 Vmat2 inhibitors and methods of use

Publications (1)

Publication Number Publication Date
KR20230160308A true KR20230160308A (ko) 2023-11-23

Family

ID=81325053

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237035676A Pending KR20230160308A (ko) 2021-03-22 2022-03-21 Vmat2 억제제 및 사용 방법

Country Status (33)

Country Link
US (3) US11718618B2 (https=)
EP (2) EP4606429A3 (https=)
JP (1) JP2024511053A (https=)
KR (1) KR20230160308A (https=)
CN (1) CN117062815A (https=)
AR (1) AR125188A1 (https=)
AU (1) AU2022241988A1 (https=)
BR (1) BR112023016273A2 (https=)
CA (1) CA3207452A1 (https=)
CL (1) CL2023002785A1 (https=)
CO (1) CO2023012322A2 (https=)
CR (1) CR20230448A (https=)
DK (1) DK4168409T3 (https=)
DO (1) DOP2023000197A (https=)
EC (1) ECSP23070370A (https=)
ES (1) ES3032498T3 (https=)
FI (1) FI4168409T3 (https=)
HR (1) HRP20250868T1 (https=)
HU (1) HUE072220T2 (https=)
IL (1) IL305054A (https=)
JO (1) JOP20230205A1 (https=)
LT (1) LT4168409T (https=)
MA (1) MA60072B1 (https=)
MD (1) MD4168409T2 (https=)
MX (1) MX2023010566A (https=)
PE (1) PE20240822A1 (https=)
PL (1) PL4168409T3 (https=)
PT (1) PT4168409T (https=)
RS (1) RS67052B1 (https=)
SI (1) SI4168409T1 (https=)
SM (1) SMT202500408T1 (https=)
TW (1) TW202304901A (https=)
WO (1) WO2022203984A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026050236A1 (en) 2024-08-27 2026-03-05 Neurocrine Biosciences, Inc. Muscarinic receptor agonist in combination with a vesicular monoamine transporter 2 inhibitor, for use in the treatment of a neurological or psychiatric disorder

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3209005A (en) 1965-09-28 Hexahydro-llbh-benzo[a] quinolizines and processes therefor
GB2410947B (en) 2004-02-11 2008-09-17 Cambridge Lab Ltd Pharmaceutical compounds
CA2650904C (en) 2006-05-02 2015-07-07 The Trustees Of The University Of Pennsylvania Radiolabeled dihydrotetrabenazine derivatives and their use as imaging agents
EP2081929B1 (en) 2006-11-08 2013-01-09 Neurocrine Biosciences, Inc. Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ol compounds and methods relating thereto
US8008500B2 (en) 2007-06-08 2011-08-30 General Electric Company Intermediates useful for making tetrabenazine compounds
US7897769B2 (en) 2007-10-25 2011-03-01 General Electric Company Intermediates for fluorinated dihydrotetrabenazine ether imaging agents and probes
US7910738B2 (en) 2007-11-29 2011-03-22 General Electric Company Intermediates for alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes
US7902364B2 (en) 2007-11-29 2011-03-08 General Electric Company Alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes
US8053578B2 (en) * 2007-11-29 2011-11-08 General Electric Company Alpha-fluoroalkyl dihydrotetrabenazine imaging agents and probes
US8013161B1 (en) 2007-12-07 2011-09-06 General Electric Company Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes
US7919622B2 (en) 2007-12-07 2011-04-05 Kande Kankanamalage Dayarathna Amarasinghe Intermediates for fluorinated tetrabenazine carbinol compounds imaging agents and probes
GB2463452A (en) 2008-09-08 2010-03-17 Cambridge Lab Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof
CA2972242A1 (en) 2008-09-18 2010-04-22 Auspex Pharmaceuticals, Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
EP3351247A1 (en) 2010-06-01 2018-07-25 Auspex Pharmaceutical, Inc. Benzoquinolone inhibitors of vmat2
PT2836241T (pt) 2012-04-10 2019-05-30 Lantheus Medical Imaging Inc Métodos de síntese de radiofármacos
EP4345100A3 (en) 2012-09-18 2024-04-10 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
US8946255B2 (en) 2012-12-28 2015-02-03 Purdue Pharma L.P. Substituted morphinans and the use thereof
JP2016506957A (ja) 2013-01-31 2016-03-07 オースペックス・ファーマシューティカルズ・インコーポレイテッドAuspex Pharmaceuticals, Inc. Vmat2のベンゾキノロン阻害剤
US20160031840A1 (en) 2013-03-15 2016-02-04 University Of Kentucky Research Foundation 1,4-Disubstituted Piperidines, 1,4-Disubstituted Piperazines, 1,4-Disubstituted Diazepines, and 1,3-Disubstituted Pyrrolidine Compounds
GB201313291D0 (en) 2013-07-25 2013-09-11 Ge Healthcare Ltd Imaging neurological disease
WO2015077521A1 (en) 2013-11-22 2015-05-28 Auspex Pharmaceuticals, Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
EP3398602A1 (en) 2014-01-27 2018-11-07 Auspex Pharmaceuticals, Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
US9714246B2 (en) 2015-02-06 2017-07-25 Neurocrine Biosciences, Inc. [9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto
RS61645B1 (sr) * 2015-10-30 2021-04-29 Neurocrine Biosciences Inc Valbenazin ditozilat i njihovi polimorfi
JP6869988B2 (ja) 2015-12-23 2021-05-12 ニューロクライン バイオサイエンシーズ,インコーポレイテッド (S)−(2R,3R,11bR)−3−イソブチル−9,10−ジメトキシ−2,3,4,6,7,11b−ヘキサヒドロ−1H−ピリド[2,1−a]イソキノリン−2−イル2−アミノ−3−メチルブタノエートジ(4−メチルベンゼンスルホネート)の調製のための合成方法
US11999676B2 (en) 2016-04-21 2024-06-04 University Of Kentucky Research Foundation Vesicular monoamine transporter-2 ligands and their use in the treatment of psychostimulant abuse
US10668030B2 (en) 2016-04-21 2020-06-02 University Of Kentucky Research Foundation Vesicular monoamine transporter-2 ligands and their use in the treatment of psychostimulant abuse
JOP20190239A1 (ar) 2017-04-19 2019-10-09 Neurocrine Biosciences Inc مركبات مثبطة لـ vmat2 وتركيبات منها
TW201906818A (zh) 2017-05-31 2019-02-16 美商511製藥公司 新穎氘取代之正子發射斷層掃描(pet)顯影劑及其藥理應用
SG11202004165UA (en) 2017-11-08 2020-06-29 Yuhua Li Esters of dihydrotetrabenazine
WO2020086765A1 (en) 2018-10-24 2020-04-30 Neurocrine Biosciences, Inc. Processes for preparing a vmat2 inhibitor
US12565495B2 (en) 2019-08-12 2026-03-03 Luye Innomind Pharma Shijiazhuang Co., Ltd. VMAT2 inhibitor and preparation method therefor and application thereof
US20210087191A1 (en) 2020-12-04 2021-03-25 Dispersol Technologies, Llc SUBSTITUTED 3-ISOBUTYL-9,10-DIMETHOXY-1,3,4,6,7,11B-HEXAHYDRO-2H-PYRIDO[2,1-a]ISOQUINOLIN-2-OL COMPOUNDS, THEIR SYNTHESIS, AND USE THEREOF
WO2022232380A1 (en) 2021-04-29 2022-11-03 Neurocrine Biosciences, Inc. Processes for preparing a vmat2 inhibitor
TW202322816A (zh) 2021-08-20 2023-06-16 美商紐羅克里生物科學有限公司 篩選 vmat2 抑制劑之方法

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BR112023016273A2 (pt) 2023-10-03
PL4168409T3 (pl) 2025-09-01
SMT202500408T1 (it) 2025-11-10
LT4168409T (lt) 2025-06-25
PT4168409T (pt) 2025-06-12
DOP2023000197A (es) 2023-11-15
SI4168409T1 (sl) 2025-08-29
CL2023002785A1 (es) 2024-02-02
CO2023012322A2 (es) 2023-10-09
US11718618B2 (en) 2023-08-08
HRP20250868T1 (hr) 2025-09-26
AU2022241988A1 (en) 2023-10-12
CR20230448A (es) 2023-10-27
MX2023010566A (es) 2023-09-21
ECSP23070370A (es) 2023-10-31
EP4168409B1 (en) 2025-05-07
JOP20230205A1 (ar) 2023-09-04
IL305054A (en) 2023-10-01
MD4168409T2 (ro) 2025-09-30
PE20240822A1 (es) 2024-04-18
CA3207452A1 (en) 2022-09-29
US20250333413A1 (en) 2025-10-30
FI4168409T3 (fi) 2025-06-25
CN117062815A (zh) 2023-11-14
MA60072B1 (fr) 2025-07-31
JP2024511053A (ja) 2024-03-12
EP4606429A3 (en) 2025-12-03
US20240010647A1 (en) 2024-01-11
DK4168409T3 (da) 2025-06-02
WO2022203984A1 (en) 2022-09-29
TW202304901A (zh) 2023-02-01
ES3032498T3 (en) 2025-07-21
HUE072220T2 (hu) 2025-11-28
EP4168409A1 (en) 2023-04-26
US20230159528A1 (en) 2023-05-25
RS67052B1 (sr) 2025-08-29
AR125188A1 (es) 2023-06-21
EP4606429A2 (en) 2025-08-27

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Patent event date: 20231018

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Patent event code: PA02012R01D

Patent event date: 20250320

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