CL2023002785A1 - Inhibidores de vmat2 y métodos de uso. - Google Patents

Inhibidores de vmat2 y métodos de uso.

Info

Publication number
CL2023002785A1
CL2023002785A1 CL2023002785A CL2023002785A CL2023002785A1 CL 2023002785 A1 CL2023002785 A1 CL 2023002785A1 CL 2023002785 A CL2023002785 A CL 2023002785A CL 2023002785 A CL2023002785 A CL 2023002785A CL 2023002785 A1 CL2023002785 A1 CL 2023002785A1
Authority
CL
Chile
Prior art keywords
methods
vmat2 inhibitors
vmat2
inhibitors
compositions
Prior art date
Application number
CL2023002785A
Other languages
English (en)
Inventor
Nicole Harriott
Nicholas Pagano
Byron A Boon
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of CL2023002785A1 publication Critical patent/CL2023002785A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Abstract

Esta divulgación se refiere en general a los compuestos inhibidores de VMAT2, composiciones y métodos relacionados con ellos.
CL2023002785A 2021-03-22 2023-09-20 Inhibidores de vmat2 y métodos de uso. CL2023002785A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202163164135P 2021-03-22 2021-03-22

Publications (1)

Publication Number Publication Date
CL2023002785A1 true CL2023002785A1 (es) 2024-02-02

Family

ID=81325053

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2023002785A CL2023002785A1 (es) 2021-03-22 2023-09-20 Inhibidores de vmat2 y métodos de uso.

Country Status (17)

Country Link
US (2) US11718618B2 (es)
EP (1) EP4168409A1 (es)
JP (1) JP2024511053A (es)
KR (1) KR20230160308A (es)
CN (1) CN117062815A (es)
AR (1) AR125188A1 (es)
AU (1) AU2022241988A1 (es)
BR (1) BR112023016273A2 (es)
CA (1) CA3207452A1 (es)
CL (1) CL2023002785A1 (es)
CO (1) CO2023012322A2 (es)
CR (1) CR20230448A (es)
DO (1) DOP2023000197A (es)
EC (1) ECSP23070370A (es)
IL (1) IL305054A (es)
TW (1) TW202304901A (es)
WO (1) WO2022203984A1 (es)

Family Cites Families (34)

* Cited by examiner, † Cited by third party
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US3209005A (en) 1965-09-28 Hexahydro-llbh-benzo[a] quinolizines and processes therefor
GB2410947B (en) 2004-02-11 2008-09-17 Cambridge Lab Ltd Pharmaceutical compounds
AU2007248764B2 (en) 2006-05-02 2013-08-01 Avid Radiopharmaceuticals, Inc. Radiolabeled dihydrotetrabenazine derivatives and their use as imaging agents
DK2081929T3 (da) 2006-11-08 2013-04-15 Neurocrine Biosciences Inc Substituerede 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11B-hexahydro-2H-pyrido[2,1-A]isoquinolin-2-ol-forbindelser og fremgangsmåder angående disse
US7897768B2 (en) 2007-06-08 2011-03-01 General Electric Company Method for making tetrabenazine compounds
US7897769B2 (en) 2007-10-25 2011-03-01 General Electric Company Intermediates for fluorinated dihydrotetrabenazine ether imaging agents and probes
US7902364B2 (en) 2007-11-29 2011-03-08 General Electric Company Alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes
US7910738B2 (en) 2007-11-29 2011-03-22 General Electric Company Intermediates for alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes
US8053578B2 (en) * 2007-11-29 2011-11-08 General Electric Company Alpha-fluoroalkyl dihydrotetrabenazine imaging agents and probes
US7919622B2 (en) 2007-12-07 2011-04-05 Kande Kankanamalage Dayarathna Amarasinghe Intermediates for fluorinated tetrabenazine carbinol compounds imaging agents and probes
US8013161B1 (en) 2007-12-07 2011-09-06 General Electric Company Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes
GB2463452A (en) 2008-09-08 2010-03-17 Cambridge Lab Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof
ES2652289T3 (es) 2008-09-18 2018-02-01 Auspex Pharmaceuticals, Inc. Derivados deuterados de benzoquinolina como inhibidores del transportador de monoamina vesicular 2
CA2801061A1 (en) 2010-06-01 2011-12-08 Auspex Pharmaceuticals, Inc. Benzoquinolone inhibitors of vmat2
ES2725314T3 (es) 2012-04-10 2019-09-23 Lantheus Medical Imaging Inc Métodos de síntesis radiofarmacéutica
WO2014047167A1 (en) 2012-09-18 2014-03-27 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
WO2014102593A1 (en) 2012-12-28 2014-07-03 Purdue Pharma L.P. Substituted morphinans and the use thereof
EP3770159A1 (en) 2013-01-31 2021-01-27 Auspex Pharmaceuticals, Inc. Benzoquinolone inhibitor of vmat2
WO2014144064A2 (en) 2013-03-15 2014-09-18 University Of Kentucky Research Foundation 1,4-disubstituted piperidines, 1,4-disubstituted piperazines, 1,4-disubstituted diazepanes, and 1,3-disubstituted pyrrolidine compounds
GB201313291D0 (en) 2013-07-25 2013-09-11 Ge Healthcare Ltd Imaging neurological disease
WO2015077521A1 (en) 2013-11-22 2015-05-28 Auspex Pharmaceuticals, Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
EP3398602A1 (en) 2014-01-27 2018-11-07 Auspex Pharmaceuticals, Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
KR102586138B1 (ko) 2015-02-06 2023-10-05 뉴로크린 바이오사이언시즈 인코퍼레이티드 [9,10-디메톡시-3-(2-메틸프로필)-1H,2H,3H,4H,6H,7H,11bH-피리도-[2,1-a]이소퀴놀린-2-일]메탄올 및 그와 관련된 화합물, 조성물 및 방법
CN108925135A (zh) 2015-12-23 2018-11-30 纽罗克里生物科学有限公司 制备(S)-(2R,3R,11bR)-3-异丁基-9,10-二甲氧基-2,3,4,6,7,11b-六氢-1H-吡啶并[2,1-a]异喹啉-2-基2-氨基-3-甲基丁酸酯二(4-甲基苯磺酸盐)的合成方法
US10668030B2 (en) 2016-04-21 2020-06-02 University Of Kentucky Research Foundation Vesicular monoamine transporter-2 ligands and their use in the treatment of psychostimulant abuse
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JOP20190239A1 (ar) 2017-04-19 2019-10-09 Neurocrine Biosciences Inc مركبات مثبطة لـ vmat2 وتركيبات منها
TW201906818A (zh) 2017-05-31 2019-02-16 美商５１１製藥公司 新穎氘取代之正子發射斷層掃描（ｐｅｔ）顯影劑及其藥理應用
BR112020008895A2 (pt) 2017-11-08 2021-03-23 Yuhua Li ésteres de di-hidrotetrabenazina
WO2020086765A1 (en) 2018-10-24 2020-04-30 Neurocrine Biosciences, Inc. Processes for preparing a vmat2 inhibitor
JP2022547390A (ja) * 2019-08-12 2022-11-14 シャンドン ルイ ファーマシューティカル カンパニー リミテッド Ｖｍａｔ２阻害剤、及びその調製方法、及びその使用
US20210087191A1 (en) 2020-12-04 2021-03-25 Dispersol Technologies, Llc SUBSTITUTED 3-ISOBUTYL-9,10-DIMETHOXY-1,3,4,6,7,11B-HEXAHYDRO-2H-PYRIDO[2,1-a]ISOQUINOLIN-2-OL COMPOUNDS, THEIR SYNTHESIS, AND USE THEREOF
WO2022232380A1 (en) 2021-04-29 2022-11-03 Neurocrine Biosciences, Inc. Processes for preparing a vmat2 inhibitor
IL310907A (en) 2021-08-20 2024-04-01 Neurocrine Biosciences Inc Screening methods for VMAT2 inhibitors

Also Published As

Publication number Publication date
ECSP23070370A (es) 2023-10-31
KR20230160308A (ko) 2023-11-23
BR112023016273A2 (pt) 2023-10-03
US20240010647A1 (en) 2024-01-11
IL305054A (en) 2023-10-01
US20230159528A1 (en) 2023-05-25
AR125188A1 (es) 2023-06-21
TW202304901A (zh) 2023-02-01
JP2024511053A (ja) 2024-03-12
CO2023012322A2 (es) 2023-10-09
US11718618B2 (en) 2023-08-08
AU2022241988A1 (en) 2023-10-12
CR20230448A (es) 2023-10-27
DOP2023000197A (es) 2023-11-15
WO2022203984A1 (en) 2022-09-29
CN117062815A (zh) 2023-11-14
CA3207452A1 (en) 2022-09-29
EP4168409A1 (en) 2023-04-26

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