KR20230156945A - 백신 조성물 및 이의 사용 방법 - Google Patents

백신 조성물 및 이의 사용 방법 Download PDF

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KR20230156945A
KR20230156945A KR1020237035159A KR20237035159A KR20230156945A KR 20230156945 A KR20230156945 A KR 20230156945A KR 1020237035159 A KR1020237035159 A KR 1020237035159A KR 20237035159 A KR20237035159 A KR 20237035159A KR 20230156945 A KR20230156945 A KR 20230156945A
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protein
polynucleotide
seq
polynucleotide encoding
acid sequence
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Korean (ko)
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바바라 머틴스
토마스 폴리어드
임레 매거
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익셉젠 인크.
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KR1020237035159A 2021-03-17 2022-03-17 백신 조성물 및 이의 사용 방법 Pending KR20230156945A (ko)

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US202163162496P 2021-03-17 2021-03-17
US63/162,496 2021-03-17
PCT/US2022/020774 WO2022197940A1 (en) 2021-03-17 2022-03-17 Vaccine compositions and methods of use thereof

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KR102832944B1 (ko) * 2024-12-27 2025-07-15 대한민국 제2형 중증급성호흡기증후군 코로나바이러스 변이들의 공통 서열을 포함하는 코로나바이러스감염증-19 범용 백신 조성물

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CN1820020B (zh) * 2003-05-06 2010-04-28 技术持有有限公司 Sars-冠状病毒病毒样颗粒以及应用方法
US7741022B2 (en) * 2006-01-18 2010-06-22 Wisconsin Alumi Research Foundation Protein inhibitor of Ran activity and methods of use thereof
US20190382450A1 (en) * 2018-06-18 2019-12-19 University Of Maryland, College Park Newcastle disease virus-based vectored vaccine
CN111748557B (zh) * 2020-04-03 2022-03-11 苏州吉玛基因股份有限公司 抑制新型冠状病毒的小干扰核酸及组合物和应用
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