KR20230144550A

KR20230144550A - 치료제로서의 cGAS 활성의 저해제

치료제로서의 cGAS 활성의 저해제 Download PDF

Info

Publication number: KR20230144550A
Authority: KR; South Korea
Prior art keywords: alkyl; methylbenzofuro; carboxylic acid; pyrrolidine; pyrimidin
Prior art date: 2021-02-11
Legal status : Pending

Application number

KR1020237028625A

Other languages

English (en)

Korean (ko)

Inventor

로버트 지. 로워리

미라 쿠마르

매튜 복서

데이비드 말로니

Original Assignee

벨부르크 랩스, 엘엘씨

Priority date

2021-02-11

Filing date

2022-02-11

Publication date

2023-10-16

2022-02-11 Application filed by 벨부르크 랩스, 엘엘씨 filed Critical 벨부르크 랩스, 엘엘씨

2023-10-16 Publication of KR20230144550A publication Critical patent/KR20230144550A/ko

Status Pending legal-status Critical Current

Links

102100031256 Cyclic GMP-AMP synthase Human genes 0.000 title claims description 64
101710118064 Cyclic GMP-AMP synthase Proteins 0.000 title claims 2
239000003814 drug Substances 0.000 title description 20
230000000694 effects Effects 0.000 title description 20
239000003112 inhibitor Substances 0.000 title description 17
229940124597 therapeutic agent Drugs 0.000 title description 7
150000001875 compounds Chemical class 0.000 claims abstract description 285
108010050904 Interferons Proteins 0.000 claims abstract description 26
102000014150 Interferons Human genes 0.000 claims abstract description 25
229940079322 interferon Drugs 0.000 claims abstract description 24
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 17
230000004913 activation Effects 0.000 claims abstract description 16
102000002227 Interferon Type I Human genes 0.000 claims abstract description 7
108010014726 Interferon Type I Proteins 0.000 claims abstract description 7
230000004044 response Effects 0.000 claims abstract description 6
-1 (2S,4R)-1-(2-methylbenzofuro[3,2-d]pyrimidin-4-yl)-4-(2-oxo-2-((4-(trifluoromethyl)phenyl )Amino)ethyl)pyrrolidine-2-carboxylic acid Chemical compound 0.000 claims description 85
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical compound OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 64
238000000034 method Methods 0.000 claims description 52
239000001257 hydrogen Substances 0.000 claims description 47
229910052739 hydrogen Inorganic materials 0.000 claims description 47
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 44
229910052736 halogen Inorganic materials 0.000 claims description 34
150000002367 halogens Chemical class 0.000 claims description 34
125000001072 heteroaryl group Chemical group 0.000 claims description 32
229910052799 carbon Inorganic materials 0.000 claims description 29
125000000217 alkyl group Chemical group 0.000 claims description 28
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 27
125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 26
125000000753 cycloalkyl group Chemical group 0.000 claims description 24
125000000623 heterocyclic group Chemical group 0.000 claims description 24
125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 23
125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 20
150000002431 hydrogen Chemical class 0.000 claims description 18
125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims description 18
125000003386 piperidinyl group Chemical group 0.000 claims description 18
208000023275 Autoimmune disease Diseases 0.000 claims description 17
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 17
150000003839 salts Chemical class 0.000 claims description 17
125000004076 pyridyl group Chemical group 0.000 claims description 16
125000003118 aryl group Chemical group 0.000 claims description 15
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208000033237 Aicardi-Goutières syndrome Diseases 0.000 claims description 12
125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims description 11
150000001204 N-oxides Chemical class 0.000 claims description 11
125000000719 pyrrolidinyl group Chemical group 0.000 claims description 11
238000011282 treatment Methods 0.000 claims description 11
125000002393 azetidinyl group Chemical group 0.000 claims description 10
125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 10
125000002883 imidazolyl group Chemical group 0.000 claims description 10
125000001041 indolyl group Chemical group 0.000 claims description 10
230000005764 inhibitory process Effects 0.000 claims description 10
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 10
239000012453 solvate Substances 0.000 claims description 10
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 9
125000004193 piperazinyl group Chemical group 0.000 claims description 9
125000003226 pyrazolyl group Chemical group 0.000 claims description 9
125000002098 pyridazinyl group Chemical group 0.000 claims description 9
125000000714 pyrimidinyl group Chemical group 0.000 claims description 9
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 8
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
239000003795 chemical substances by application Substances 0.000 claims description 8
AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims description 8
125000006513 pyridinyl methyl group Chemical group 0.000 claims description 8
208000021386 Sjogren Syndrome Diseases 0.000 claims description 7
125000002757 morpholinyl group Chemical group 0.000 claims description 7
125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 6
239000003085 diluting agent Substances 0.000 claims description 5
208000036546 leukodystrophy Diseases 0.000 claims description 5
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 4
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
239000002904 solvent Substances 0.000 claims description 4
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