KR20230142712A - 아데노-연관된 바이러스(aav) 생산 - Google Patents

아데노-연관된 바이러스(aav) 생산 Download PDF

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KR20230142712A
KR20230142712A KR1020237025723A KR20237025723A KR20230142712A KR 20230142712 A KR20230142712 A KR 20230142712A KR 1020237025723 A KR1020237025723 A KR 1020237025723A KR 20237025723 A KR20237025723 A KR 20237025723A KR 20230142712 A KR20230142712 A KR 20230142712A
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cells
complementation
vector
iii
aav
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Korean (ko)
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빙난 구
제니퍼 왕
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론자 휴스턴, 아이엔씨.
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151Methods of production or purification of viral material
    • C12N2750/14152Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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    • C12N2800/00Nucleic acids vectors
    • C12N2800/40Systems of functionally co-operating vectors

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  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020237025723A 2021-02-11 2022-02-10 아데노-연관된 바이러스(aav) 생산 Pending KR20230142712A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163148350P 2021-02-11 2021-02-11
US63/148,350 2021-02-11
PCT/US2022/015975 WO2022173944A1 (en) 2021-02-11 2022-02-10 Adeno-associated virus (aav) production

Publications (1)

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KR20230142712A true KR20230142712A (ko) 2023-10-11

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KR1020237025723A Pending KR20230142712A (ko) 2021-02-11 2022-02-10 아데노-연관된 바이러스(aav) 생산

Country Status (8)

Country Link
US (1) US20220259572A1 (https=)
EP (1) EP4291665A1 (https=)
JP (1) JP2024506279A (https=)
KR (1) KR20230142712A (https=)
CN (1) CN116917490A (https=)
CA (1) CA3206771A1 (https=)
IL (1) IL304688A (https=)
WO (1) WO2022173944A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202323529A (zh) 2021-10-18 2023-06-16 美商再生元醫藥公司 包括腺病毒相關病毒聚核苷酸的真核細胞
CN120092093A (zh) * 2022-08-25 2025-06-03 富士胶片株式会社 靶病毒的制造方法及培养组合物
JP2025534369A (ja) 2022-09-30 2025-10-15 ポリプラス トランスフェクション 3種の異なるヘルパーウイルス由来のヘルパーエレメントを含むキメラヘルパー核酸分子
AU2024332181A1 (en) 2023-08-31 2026-02-12 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof
CN121780618A (zh) * 2023-12-13 2026-04-03 广州派真生物技术有限公司 一种高产重组腺相关病毒的辅助质粒及应用
TW202545971A (zh) 2024-02-08 2025-12-01 美商戴諾治療公司 殼體多肽及其使用方法
WO2025168663A1 (en) 2024-02-09 2025-08-14 F. Hoffmann-La Roche Ag Method for producing recombinant adeno-associated viral particles
WO2025252480A1 (en) 2024-06-07 2025-12-11 F. Hoffmann-La Roche Ag Method for purifying plasmid dna
WO2026022064A1 (en) 2024-07-22 2026-01-29 F. Hoffmann-La Roche Ag Novel aav rep orfs and rep polypeptides
WO2026037757A1 (en) 2024-08-13 2026-02-19 F. Hoffmann-La Roche Ag Modified aav particles
WO2026064442A2 (en) 2024-09-18 2026-03-26 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof
WO2026064428A2 (en) 2024-09-18 2026-03-26 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof
WO2026064444A1 (en) 2024-09-18 2026-03-26 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1064393B1 (en) * 1998-03-20 2004-12-29 The Trustees Of The University Of Pennsylvania Compositions and methods for helper-free production of recombinant adeno-associated viruses
CN103476399A (zh) * 2011-04-18 2013-12-25 独立行政法人国立精神·神经医疗研究中心 药剂递送粒子及其制造方法

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US20220259572A1 (en) 2022-08-18
IL304688A (en) 2023-09-01
EP4291665A1 (en) 2023-12-20
JP2024506279A (ja) 2024-02-13
WO2022173944A1 (en) 2022-08-18
CN116917490A (zh) 2023-10-20
CA3206771A1 (en) 2022-08-18

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