KR20230128137A - 항-il-22r 항체 - Google Patents

항-il-22r 항체 Download PDF

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Publication number
KR20230128137A
KR20230128137A KR1020237028376A KR20237028376A KR20230128137A KR 20230128137 A KR20230128137 A KR 20230128137A KR 1020237028376 A KR1020237028376 A KR 1020237028376A KR 20237028376 A KR20237028376 A KR 20237028376A KR 20230128137 A KR20230128137 A KR 20230128137A
Authority
KR
South Korea
Prior art keywords
seq
antibody
antigen
sequence
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020237028376A
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English (en)
Korean (ko)
Inventor
크리스토프 프레드릭 제롬 블랑쉐토트
버지트 오르소
타인 스카크-니엘센
말렌느 버텔센
세바스찬 반 데르 워닝
마이클 사운더스
요하네스 요셉 빌헬무스 드 하아드
Original Assignee
아르제넥스 비브이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아르제넥스 비브이 filed Critical 아르제넥스 비브이
Publication of KR20230128137A publication Critical patent/KR20230128137A/ko
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020237028376A 2016-07-15 2017-07-14 항-il-22r 항체 Ceased KR20230128137A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB1612337.4 2016-07-15
GBGB1612337.4A GB201612337D0 (en) 2016-07-15 2016-07-15 Ant-il-22r antibodies
PCT/EP2017/067923 WO2018011420A1 (en) 2016-07-15 2017-07-14 Anti-il-22r antibodies
KR1020197001500A KR102571012B1 (ko) 2016-07-15 2017-07-14 항-il-22r 항체

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197001500A Division KR102571012B1 (ko) 2016-07-15 2017-07-14 항-il-22r 항체

Publications (1)

Publication Number Publication Date
KR20230128137A true KR20230128137A (ko) 2023-09-01

Family

ID=56890507

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020197001500A Active KR102571012B1 (ko) 2016-07-15 2017-07-14 항-il-22r 항체
KR1020237028376A Ceased KR20230128137A (ko) 2016-07-15 2017-07-14 항-il-22r 항체

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020197001500A Active KR102571012B1 (ko) 2016-07-15 2017-07-14 항-il-22r 항체

Country Status (27)

Country Link
US (4) US10696741B2 (enExample)
EP (2) EP3484921B1 (enExample)
JP (1) JP7163275B2 (enExample)
KR (2) KR102571012B1 (enExample)
CN (1) CN109641966B (enExample)
AU (1) AU2017296094B2 (enExample)
BR (1) BR112019000788A2 (enExample)
CA (1) CA3024370A1 (enExample)
CY (1) CY1125041T1 (enExample)
DK (1) DK3484921T3 (enExample)
ES (1) ES2903412T3 (enExample)
GB (1) GB201612337D0 (enExample)
HR (1) HRP20220197T1 (enExample)
HU (1) HUE057615T2 (enExample)
IL (1) IL264262B2 (enExample)
LT (1) LT3484921T (enExample)
MX (1) MX2019000539A (enExample)
MY (1) MY197821A (enExample)
PL (1) PL3484921T3 (enExample)
PT (1) PT3484921T (enExample)
RS (1) RS62884B1 (enExample)
RU (1) RU2758721C2 (enExample)
SA (1) SA519400856B1 (enExample)
SG (1) SG11201900128XA (enExample)
SI (1) SI3484921T1 (enExample)
UA (1) UA125585C2 (enExample)
WO (1) WO2018011420A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201612337D0 (en) 2016-07-15 2016-08-31 Argen-X N V Ant-il-22r antibodies
CA3102391A1 (en) * 2018-06-05 2019-12-12 Bioatla, Inc. Anti-il-22 antibodies, antibody fragments, their immunoconjugates and uses thereof
CN110302363B (zh) * 2019-07-04 2020-10-09 北京大学第三医院（北京大学第三临床医学院） Il-22作为制备治疗pcos药物的应用及药物制剂
EP4531804A1 (en) 2022-06-03 2025-04-09 LEO Pharma A/S Liquid formulation of il-22r antibody
WO2024184333A1 (en) 2023-03-08 2024-09-12 Leo Pharma A/S Il-22r antibody for use in treating atopic dermatitis

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
KR20050116392A (ko) * 2003-03-24 2005-12-12 지모제넥틱스, 인코포레이티드 항-ｉｌ-22ｒａ 항체 및 결합 파트너 및 염증에 있어서의사용 방법
BRPI0516975A (pt) 2004-10-22 2008-09-30 Zymogenetics Inc anticorpo ou seu fragmento de ligação a antìgeno, composição farmacêutica, imunoconjugado, hibridoma, anticorpo monoclonal, e, uso de um anticorpo ou seu fragmento de ligação a antìgeno
CN105859886A (zh) * 2005-12-02 2016-08-17 健泰科生物技术公司 牵涉与il-22和il-22r结合的抗体的组合物和方法
GB2461546B (en) 2008-07-02 2010-07-07 Argen X Bv Antigen binding polypeptides
CN102665759B (zh) * 2009-11-19 2015-09-30 默克雪兰诺有限公司 人源化抗il-22ra抗体
GB2476681B (en) 2010-01-04 2012-04-04 Argen X Bv Humanized camelid VH, VK and VL immunoglobulin domains
GB2504139B (en) * 2012-07-20 2014-12-31 Argen X Bv Antibodies to highly conserved targets produced by the immunisation of Camelidae species
WO2013087912A1 (en) * 2011-12-16 2013-06-20 Synthon Biopharmaceuticals B.V. Compounds and methods for treating inflammatory diseases
EP2890711B1 (en) 2012-08-31 2017-01-04 Argen-X Nv Method for producing antibody molecules having inter-species, intra-target cross-reactivity
US10093737B2 (en) * 2013-03-01 2018-10-09 Albert Einstein College Of Medicine, Inc. HHLA2 as a novel inhibitor of human immune system and uses thereof
CN105601739B (zh) * 2016-02-22 2019-01-18 王晨辉 一种人源化抗白介素22基因工程抗体及其应用
GB201612337D0 (en) 2016-07-15 2016-08-31 Argen-X N V Ant-il-22r antibodies

Also Published As

Publication number Publication date
RU2758721C2 (ru) 2021-11-01
EP3484921A1 (en) 2019-05-22
EP3484921B1 (en) 2021-11-17
CA3024370A1 (en) 2018-01-18
SA519400856B1 (ar) 2022-10-25
WO2018011420A1 (en) 2018-01-18
US20200157207A1 (en) 2020-05-21
US20230088269A1 (en) 2023-03-23
JP2019528046A (ja) 2019-10-10
EP4023674A2 (en) 2022-07-06
SG11201900128XA (en) 2019-02-27
ES2903412T3 (es) 2022-04-01
DK3484921T3 (da) 2022-02-07
CN109641966B (zh) 2022-08-23
HRP20220197T1 (hr) 2022-04-29
US20200216528A1 (en) 2020-07-09
RS62884B1 (sr) 2022-03-31
NZ748737A (en) 2025-06-27
AU2017296094B2 (en) 2024-02-01
MY197821A (en) 2023-07-18
RU2019103991A (ru) 2020-08-17
AU2017296094A1 (en) 2018-12-13
KR102571012B1 (ko) 2023-08-24
IL264262B1 (en) 2024-07-01
HUE057615T2 (hu) 2022-05-28
US11261246B2 (en) 2022-03-01
KR20190026766A (ko) 2019-03-13
US10696741B2 (en) 2020-06-30
GB201612337D0 (en) 2016-08-31
CN109641966A (zh) 2019-04-16
EP4023674A3 (en) 2022-10-05
SI3484921T1 (sl) 2022-02-28
CY1125041T1 (el) 2023-03-24
IL264262B2 (en) 2024-11-01
PL3484921T3 (pl) 2022-03-28
UA125585C2 (uk) 2022-04-27
LT3484921T (lt) 2022-01-10
IL264262A (en) 2019-02-28
MX2019000539A (es) 2019-10-04
RU2019103991A3 (enExample) 2021-04-29
US11447544B2 (en) 2022-09-20
US20190127459A1 (en) 2019-05-02
BR112019000788A2 (pt) 2019-07-02
JP7163275B2 (ja) 2022-10-31
PT3484921T (pt) 2022-01-26

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Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20230821

Application number text: 1020197001500

Filing date: 20190116

PG1501 Laying open of application
E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20250217

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D