KR20230114274A - 5α-하이드록시-6β-[2-(1H-이미다졸-4-일)에틸아미노]콜레스탄-3β-올의전구약물 및 암 치료에 사용하기 위한 이를 포함하는 약제학적 조성물 - Google Patents

5α-하이드록시-6β-[2-(1H-이미다졸-4-일)에틸아미노]콜레스탄-3β-올의전구약물 및 암 치료에 사용하기 위한 이를 포함하는 약제학적 조성물 Download PDF

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Publication number
KR20230114274A
KR20230114274A KR1020237021722A KR20237021722A KR20230114274A KR 20230114274 A KR20230114274 A KR 20230114274A KR 1020237021722 A KR1020237021722 A KR 1020237021722A KR 20237021722 A KR20237021722 A KR 20237021722A KR 20230114274 A KR20230114274 A KR 20230114274A
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KR
South Korea
Prior art keywords
imidazol
ethylamino
hydroxy
cholestan
compound
Prior art date
Application number
KR1020237021722A
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English (en)
Korean (ko)
Inventor
스테판 실벤트
퀜틴 말리에
??틴 말리에
아르노 리베스
니콜라스 카론
다리오 모스카
헬렌 미쇼
Original Assignee
덴드로게닉스
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Publication date
Application filed by 덴드로게닉스 filed Critical 덴드로게닉스
Publication of KR20230114274A publication Critical patent/KR20230114274A/ko

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/36Arsenic; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020237021722A 2020-12-03 2021-12-03 5α-하이드록시-6β-[2-(1H-이미다졸-4-일)에틸아미노]콜레스탄-3β-올의전구약물 및 암 치료에 사용하기 위한 이를 포함하는 약제학적 조성물 KR20230114274A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BE20205878A BE1028852B1 (fr) 2020-12-03 2020-12-03 PRODROGUE DU 5α-hydroxy-6β-[2-(1H-imidazol-4-yl) éthylamino]cholestan-3β-ol ET COMPOSITIONS PHARMACEUTIQUES LE COMPRENANT POUR UTILISATION DANS LE TRAITEMENT DU CANCER
BE20205878 2020-12-03
PCT/EP2021/084191 WO2022117824A1 (fr) 2020-12-03 2021-12-03 PRODROGUE DU 5α-HYDROXY-6β-[2-(1H-IMIDAZOL-4-YL)ETHYLAMINO]CHOLESTAN-3β-OL ET COMPOSITIONS PHARMACEUTIQUES LE COMPRENANT POUR UTILISATION DANS LE TRAITEMENT DU CANCER

Publications (1)

Publication Number Publication Date
KR20230114274A true KR20230114274A (ko) 2023-08-01

Family

ID=74175504

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237021722A KR20230114274A (ko) 2020-12-03 2021-12-03 5α-하이드록시-6β-[2-(1H-이미다졸-4-일)에틸아미노]콜레스탄-3β-올의전구약물 및 암 치료에 사용하기 위한 이를 포함하는 약제학적 조성물

Country Status (9)

Country Link
US (1) US20240002429A1 (fr)
EP (1) EP4255441A1 (fr)
JP (1) JP2024503572A (fr)
KR (1) KR20230114274A (fr)
CN (2) CN116615202A (fr)
AU (1) AU2021391628A1 (fr)
BE (1) BE1028852B1 (fr)
CA (1) CA3200327A1 (fr)
WO (1) WO2022117824A1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140098131A (ko) 2011-11-24 2014-08-07 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 스테롤 유도체의 제조 공정
CN105611934A (zh) * 2013-09-04 2016-05-25 艾菲彻姆 用于治疗化学敏感性或化学耐药性肿瘤的Dendrogenin A和抗肿瘤剂

Also Published As

Publication number Publication date
AU2021391628A1 (en) 2023-06-29
CN116615202A (zh) 2023-08-18
BE1028852A1 (fr) 2022-06-28
EP4255441A1 (fr) 2023-10-11
WO2022117824A1 (fr) 2022-06-09
US20240002429A1 (en) 2024-01-04
CN116546988A (zh) 2023-08-04
BE1028852B1 (fr) 2022-07-05
JP2024503572A (ja) 2024-01-26
CA3200327A1 (fr) 2022-06-09

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