KR20230112605A

KR20230112605A - 키나아제 억제제 및 그의 용도

키나아제 억제제 및 그의 용도 Download PDF

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Publication number: KR20230112605A
Authority: KR; South Korea
Prior art keywords: optionally substituted; alkyl; pharmaceutically acceptable; compound; heterocyclyl
Prior art date: 2020-08-07
Legal status : Pending

Application number

KR1020237007882A

Other languages

English (en)

Korean (ko)

Inventor

첸 첸

Original Assignee

에이비엠 쎄라퓨틱스 코포레이션

Priority date

2020-08-07

Filing date

2021-08-06

Publication date

2023-07-27

2021-08-06 Application filed by 에이비엠 쎄라퓨틱스 코포레이션 filed Critical 에이비엠 쎄라퓨틱스 코포레이션

2023-07-27 Publication of KR20230112605A publication Critical patent/KR20230112605A/ko

Status Pending legal-status Critical Current

Links

229940043355 kinase inhibitor Drugs 0.000 title description 2
239000003757 phosphotransferase inhibitor Substances 0.000 title description 2
-1 Cyclic iminopyridine compounds Chemical class 0.000 claims abstract description 350
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238000000034 method Methods 0.000 claims abstract description 63
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 53
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238000011282 treatment Methods 0.000 claims abstract description 31
208000035475 disorder Diseases 0.000 claims abstract description 27
230000002062 proliferating effect Effects 0.000 claims abstract description 21
108091000080 Phosphotransferase Proteins 0.000 claims abstract description 19
102000020233 phosphotransferase Human genes 0.000 claims abstract description 19
108091054455 MAP kinase family Proteins 0.000 claims abstract description 16
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102100030340 Ephrin type-A receptor 2 Human genes 0.000 claims abstract description 12
101100181041 Arabidopsis thaliana KINUA gene Proteins 0.000 claims abstract description 11
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125000001072 heteroaryl group Chemical group 0.000 claims description 173
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125000004093 cyano group Chemical group *C#N 0.000 claims description 24
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 23
125000004432 carbon atom Chemical group C* 0.000 claims description 19
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206010020718 hyperplasia Diseases 0.000 claims description 11
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