KR20230038318A - 불응성 호지킨 림프종에서의 니볼루맙을 사용한 pd-1 차단 - Google Patents

불응성 호지킨 림프종에서의 니볼루맙을 사용한 pd-1 차단 Download PDF

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KR20230038318A
KR20230038318A KR1020237008131A KR20237008131A KR20230038318A KR 20230038318 A KR20230038318 A KR 20230038318A KR 1020237008131 A KR1020237008131 A KR 1020237008131A KR 20237008131 A KR20237008131 A KR 20237008131A KR 20230038318 A KR20230038318 A KR 20230038318A
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antibody
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베네데토 파르사치
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브리스톨-마이어스 스큅 컴퍼니
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020237008131A 2016-06-02 2017-06-01 불응성 호지킨 림프종에서의 니볼루맙을 사용한 pd-1 차단 Ceased KR20230038318A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662344880P 2016-06-02 2016-06-02
US62/344,880 2016-06-02
KR1020187037835A KR20190015377A (ko) 2016-06-02 2017-06-01 불응성 호지킨 림프종에서의 니볼루맙을 사용한 pd-1 차단
PCT/US2017/035492 WO2017210453A1 (en) 2016-06-02 2017-06-01 Pd-1 blockade with nivolumab in refractory hodgkin's lymphoma

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020187037835A Division KR20190015377A (ko) 2016-06-02 2017-06-01 불응성 호지킨 림프종에서의 니볼루맙을 사용한 pd-1 차단

Publications (1)

Publication Number Publication Date
KR20230038318A true KR20230038318A (ko) 2023-03-17

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ID=59067911

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Application Number Title Priority Date Filing Date
KR1020187037835A Ceased KR20190015377A (ko) 2016-06-02 2017-06-01 불응성 호지킨 림프종에서의 니볼루맙을 사용한 pd-1 차단
KR1020237008131A Ceased KR20230038318A (ko) 2016-06-02 2017-06-01 불응성 호지킨 림프종에서의 니볼루맙을 사용한 pd-1 차단

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KR1020187037835A Ceased KR20190015377A (ko) 2016-06-02 2017-06-01 불응성 호지킨 림프종에서의 니볼루맙을 사용한 pd-1 차단

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US (3) US11083790B2 (enExample)
EP (2) EP3463457B1 (enExample)
JP (3) JP7175198B2 (enExample)
KR (2) KR20190015377A (enExample)
CN (1) CN109475633A (enExample)
DK (1) DK3463457T3 (enExample)
ES (1) ES2954139T3 (enExample)
FI (1) FI3463457T3 (enExample)
HR (1) HRP20230864T1 (enExample)
HU (1) HUE062398T2 (enExample)
LT (1) LT3463457T (enExample)
PL (1) PL3463457T3 (enExample)
PT (1) PT3463457T (enExample)
RS (1) RS64388B1 (enExample)
SI (1) SI3463457T1 (enExample)
SM (1) SMT202300290T1 (enExample)
WO (1) WO2017210453A1 (enExample)

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KR20190015377A (ko) 2016-06-02 2019-02-13 브리스톨-마이어스 스큅 컴퍼니 불응성 호지킨 림프종에서의 니볼루맙을 사용한 pd-1 차단
FI3464368T3 (fi) 2016-06-02 2023-09-12 Bristol Myers Squibb Co Anti-pd-1-vasta-aineen käyttö yhdistelmänä anti-cd30-vasta-aineen kanssa lymfooman hoitamisessa
CN111770936A (zh) * 2018-01-12 2020-10-13 百时美施贵宝公司 抗il-8抗体和抗pd-1抗体联合治疗用于治疗癌症
MA51844A (fr) * 2018-02-13 2021-05-19 Merck Sharp & Dohme Méthodes de traitement du cancer avec des anticorps anti pd-1 et des anticorps anti ctla4
CN113164599B (zh) * 2018-12-24 2023-08-01 正大天晴药业集团股份有限公司 抗pd-l1单克隆抗体治疗癌症的用途
EP3946625A1 (en) * 2019-03-28 2022-02-09 Bristol-Myers Squibb Company Methods of treating tumor
WO2025136845A1 (en) * 2023-12-19 2025-06-26 Merck Sharp & Dohme Llc Methods of treating a patient with a pd-1 antagonist

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Publication number Publication date
HRP20230864T1 (hr) 2023-11-10
RS64388B1 (sr) 2023-08-31
PL3463457T3 (pl) 2023-08-21
EP4248990A2 (en) 2023-09-27
KR20190015377A (ko) 2019-02-13
JP7568698B2 (ja) 2024-10-16
JP2023025012A (ja) 2023-02-21
US20250134996A1 (en) 2025-05-01
SMT202300290T1 (it) 2023-11-13
EP3463457B1 (en) 2023-06-28
SI3463457T1 (sl) 2023-09-29
FI3463457T3 (fi) 2023-09-12
US11083790B2 (en) 2021-08-10
DK3463457T3 (da) 2023-10-02
PT3463457T (pt) 2023-09-07
EP3463457A1 (en) 2019-04-10
JP2019517504A (ja) 2019-06-24
LT3463457T (lt) 2023-09-11
HUE062398T2 (hu) 2023-10-28
US20190290757A1 (en) 2019-09-26
EP4248990A3 (en) 2024-01-03
JP2025020119A (ja) 2025-02-12
CN109475633A (zh) 2019-03-15
WO2017210453A1 (en) 2017-12-07
US20220025049A1 (en) 2022-01-27
JP7175198B2 (ja) 2022-11-18
ES2954139T3 (es) 2023-11-20

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