KR20230010228A - 자연 살해 세포를 표적으로 하는 키메라 항원 수용체 (cars) - Google Patents

자연 살해 세포를 표적으로 하는 키메라 항원 수용체 (cars) Download PDF

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KR20230010228A
KR20230010228A KR1020227043093A KR20227043093A KR20230010228A KR 20230010228 A KR20230010228 A KR 20230010228A KR 1020227043093 A KR1020227043093 A KR 1020227043093A KR 20227043093 A KR20227043093 A KR 20227043093A KR 20230010228 A KR20230010228 A KR 20230010228A
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seq
set forth
car
sequence set
domain
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Korean (ko)
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토르 웨그너
플로리안 엔가코 카메니
Original Assignee
시애틀 칠드런즈 호스피탈 디/비/에이 시애틀 칠드런즈 리서치 인스티튜트
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Publication of KR20230010228A publication Critical patent/KR20230010228A/ko
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KR1020227043093A 2020-05-08 2021-05-07 자연 살해 세포를 표적으로 하는 키메라 항원 수용체 (cars) Pending KR20230010228A (ko)

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Application Number Priority Date Filing Date Title
US202063022149P 2020-05-08 2020-05-08
US63/022,149 2020-05-08
PCT/US2021/031421 WO2021226543A2 (en) 2020-05-08 2021-05-07 Chimeric antigen receptors (cars) targeting natural killer cells

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KR20230010228A true KR20230010228A (ko) 2023-01-18

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US (1) US20230348854A1 (enExample)
EP (1) EP4146703A4 (enExample)
JP (1) JP2023525049A (enExample)
KR (1) KR20230010228A (enExample)
CN (1) CN115551893A (enExample)
WO (1) WO2021226543A2 (enExample)

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WO2021249462A1 (zh) * 2020-06-11 2021-12-16 南京北恒生物科技有限公司 表达nk抑制性分子的工程化免疫细胞及其用途
US11802866B2 (en) * 2021-07-08 2023-10-31 Medic Life Sciences Inc. High-throughput screening system for identification of novel drugs and drug targets
EP4569117A2 (en) * 2022-08-11 2025-06-18 The Trustees of The University of Pennsylvania Universal t cells and compositions and methods of use thereof
JP2025005236A (ja) * 2023-06-27 2025-01-16 国立大学法人 東京大学 タンパク質シンチレーター
WO2025168691A1 (en) * 2024-02-07 2025-08-14 Astrazeneca Ab Engineered cells expressing modified hla-e polypeptide
CN120647771A (zh) * 2024-03-15 2025-09-16 上海鑫湾生物科技有限公司 一种激活免疫细胞杀伤肿瘤细胞的融合蛋白及其重组病毒和用途
WO2025225645A1 (ja) * 2024-04-24 2025-10-30 第一三共株式会社 Ｎｋｇ２ａアゴニストを用いた免疫拒絶の回避方法

Family Cites Families (22)

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Publication number Priority date Publication date Assignee Title
US6194548B1 (en) * 1998-01-23 2001-02-27 Takashi Osumi Green fluorescent proteins and blue fluorescent proteins
AU2008204433B2 (en) * 2007-01-11 2014-03-13 Novo Nordisk A/S Anti-KIR antibodies, formulations, and uses thereof
MX2010007935A (es) * 2008-01-24 2010-08-23 Novo Nordisk As Anticuerpo monoclonal humanizado anti-nkg2a humano.
DK2699593T4 (da) * 2011-04-20 2021-02-08 Univ Washington Through Its Center For Commercialization Beta-2 mikroglobulin-deficiente celler
EP2814846B1 (en) * 2012-02-13 2020-01-08 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
AU2015316993B2 (en) * 2014-09-16 2021-03-18 Innate Pharma Treatment regimens using anti-NKG2A antibodies
KR20250007689A (ko) * 2014-09-16 2025-01-14 이나뜨 파르마 에스.에이. 림프구에서의 억제 경로의 중화
CN107429253B (zh) * 2014-12-05 2021-11-05 希望之城公司 Cs1靶向性嵌合抗原受体修饰的t细胞
GB201503742D0 (en) * 2015-03-05 2015-04-22 Ucl Business Plc Chimeric antigen receptor
AU2016284871B2 (en) * 2015-06-23 2022-09-29 Innate Pharma Multispecific NK engager proteins
EP3325967B1 (en) * 2015-07-24 2019-12-04 Innate Pharma Methods for detecting tissue infiltrating nk cells
US10222369B2 (en) * 2016-05-17 2019-03-05 Chimera Bioengineering, Inc. Methods for making novel antigen binding domains
KR102708285B1 (ko) * 2017-03-13 2024-09-20 포세이다 테라퓨틱스, 인크. 조혈 줄기세포의 선택적 제거 및 대체를 위한 조성물 및 방법
JP2020536531A (ja) * 2017-09-26 2020-12-17 ロングウッド ユニバーシティーＬｏｎｇｗｏｏｄ Ｕｎｉｖｅｒｓｉｔｙ 免疫療法としてのｐｄ１特異的キメラ抗原受容体
IL315737A (en) * 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
CN109694854B (zh) * 2017-10-20 2023-11-21 亘喜生物科技（上海）有限公司 通用型嵌合抗原受体t细胞制备技术
US11851679B2 (en) * 2017-11-01 2023-12-26 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
WO2019129851A1 (en) * 2017-12-29 2019-07-04 Cellectis Method for improving production of car t cells
CN110856724B (zh) * 2018-08-24 2022-05-27 杭州康万达医药科技有限公司 包含核酸及car修饰的免疫细胞的治疗剂及其应用
US12473345B2 (en) * 2018-11-01 2025-11-18 Juno Therapeutics, Inc. Methods for treatment using chimeric antigen receptors specific for B-cell maturation antigen
CN109734814A (zh) * 2019-02-12 2019-05-10 南京卡提医学科技有限公司 具有免疫受体的工程化t细胞治疗癌症的用途
EP4150058A4 (en) * 2020-05-13 2024-06-19 Nanjing Legend Biotech Co., Ltd. COMPOSITIONS AND METHODS FOR REDUCING HOST REJECTION OF ALLOGENIC CELLS USING MONKEY ICP47 AND VARIANTS THEREOF

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