KR20220140647A - 과다운동성 운동 장애의 치료를 위한 vmat2 억제제 - Google Patents

과다운동성 운동 장애의 치료를 위한 vmat2 억제제 Download PDF

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Publication number
KR20220140647A
KR20220140647A KR1020227034399A KR20227034399A KR20220140647A KR 20220140647 A KR20220140647 A KR 20220140647A KR 1020227034399 A KR1020227034399 A KR 1020227034399A KR 20227034399 A KR20227034399 A KR 20227034399A KR 20220140647 A KR20220140647 A KR 20220140647A
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KR
South Korea
Prior art keywords
htbz
dimethoxy
isobutyl
pyrido
isoquinolin
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Ceased
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KR1020227034399A
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English (en)
Korean (ko)
Inventor
크리스토퍼 에프. 오브라이언
Original Assignee
뉴로크린 바이오사이언시즈 인코퍼레이티드
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Priority to KR1020247001490A priority Critical patent/KR20240011255A/ko
Publication of KR20220140647A publication Critical patent/KR20220140647A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020227034399A 2014-05-06 2015-05-06 과다운동성 운동 장애의 치료를 위한 vmat2 억제제 Ceased KR20220140647A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247001490A KR20240011255A (ko) 2014-05-06 2015-05-06 과다운동성 운동 장애의 치료를 위한 vmat2 억제제

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461989240P 2014-05-06 2014-05-06
US61/989,240 2014-05-06
KR1020207032879A KR20200133003A (ko) 2014-05-06 2015-05-06 과다운동성 운동 장애의 치료를 위한 vmat2 억제제
PCT/US2015/029519 WO2015171802A1 (en) 2014-05-06 2015-05-06 Vmat2 inhibitors for the treatment of hyperkinetic movement disorders

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020207032879A Division KR20200133003A (ko) 2014-05-06 2015-05-06 과다운동성 운동 장애의 치료를 위한 vmat2 억제제

Related Child Applications (1)

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KR1020247001490A Division KR20240011255A (ko) 2014-05-06 2015-05-06 과다운동성 운동 장애의 치료를 위한 vmat2 억제제

Publications (1)

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KR20220140647A true KR20220140647A (ko) 2022-10-18

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Application Number Title Priority Date Filing Date
KR1020227034399A Ceased KR20220140647A (ko) 2014-05-06 2015-05-06 과다운동성 운동 장애의 치료를 위한 vmat2 억제제
KR1020207032879A Ceased KR20200133003A (ko) 2014-05-06 2015-05-06 과다운동성 운동 장애의 치료를 위한 vmat2 억제제
KR1020247001490A Ceased KR20240011255A (ko) 2014-05-06 2015-05-06 과다운동성 운동 장애의 치료를 위한 vmat2 억제제
KR1020257005033A Pending KR20250029267A (ko) 2014-05-06 2015-05-06 과다운동성 운동 장애의 치료를 위한 vmat2 억제제
KR1020167033765A Ceased KR20160147044A (ko) 2014-05-06 2015-05-06 과다운동성 운동 장애의 치료를 위한 vmat2 억제제

Family Applications After (4)

Application Number Title Priority Date Filing Date
KR1020207032879A Ceased KR20200133003A (ko) 2014-05-06 2015-05-06 과다운동성 운동 장애의 치료를 위한 vmat2 억제제
KR1020247001490A Ceased KR20240011255A (ko) 2014-05-06 2015-05-06 과다운동성 운동 장애의 치료를 위한 vmat2 억제제
KR1020257005033A Pending KR20250029267A (ko) 2014-05-06 2015-05-06 과다운동성 운동 장애의 치료를 위한 vmat2 억제제
KR1020167033765A Ceased KR20160147044A (ko) 2014-05-06 2015-05-06 과다운동성 운동 장애의 치료를 위한 vmat2 억제제

Country Status (24)

Country Link
US (3) US20170071932A1 (enExample)
EP (3) EP4389227A3 (enExample)
JP (4) JP6635945B2 (enExample)
KR (5) KR20220140647A (enExample)
CN (3) CN112741835A (enExample)
AU (1) AU2015256012B2 (enExample)
CA (1) CA2947736C (enExample)
CY (1) CY1125058T1 (enExample)
DK (2) DK3139925T3 (enExample)
ES (2) ES2904526T3 (enExample)
FI (1) FI3936130T3 (enExample)
HR (2) HRP20220025T1 (enExample)
HU (2) HUE066361T2 (enExample)
IL (1) IL248745B (enExample)
LT (2) LT3139925T (enExample)
MX (1) MX387625B (enExample)
NZ (1) NZ725826A (enExample)
PL (2) PL3139925T3 (enExample)
PT (2) PT3139925T (enExample)
RS (2) RS65359B1 (enExample)
RU (1) RU2753740C2 (enExample)
SI (2) SI3936130T1 (enExample)
SM (2) SMT202400199T1 (enExample)
WO (1) WO2015171802A1 (enExample)

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LT3875459T (lt) * 2015-10-30 2024-02-26 Neurocrine Biosciences, Inc. Valbenazino dihidrochlorido druskos ir jų polimorfai
CA3009169A1 (en) * 2015-12-23 2017-06-29 Neurocrine Biosciences, Inc. Synthetic methods for preparation of (s)-(2r,3r,11br)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1h-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate)
EP3473623B1 (en) 2016-06-29 2020-07-15 Crystal Pharmaceutical (Suzhou) Co., Ltd. Crystal forms of nbi-98854, preparation method therefor and use thereof
JP2020500875A (ja) * 2016-12-02 2020-01-16 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 統合失調症または統合失調感情障害を処置するためのバルベナジンの使用
US10703750B2 (en) 2017-01-10 2020-07-07 Sandoz Ag Crystalline valbenazine free base
JP7090151B2 (ja) 2017-01-27 2022-06-23 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 特定のｖｍａｔ２インヒビターを投与するための方法
US10954235B2 (en) 2017-02-27 2021-03-23 Sandoz Ag Crystalline forms of valbenazine salts
WO2018164996A1 (en) * 2017-03-06 2018-09-13 Neurocrine Biosciences, Inc. Dosing regimen for valbenazine
JP2020512986A (ja) * 2017-04-01 2020-04-30 アデプティオ ファーマシューティカルズ リミテッド 運動障害の治療に使用するための（＋）−α−ジヒドロテトラベナジン
GB201705302D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705304D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705306D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705305D0 (en) * 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
US20190111035A1 (en) * 2017-04-01 2019-04-18 Adeptio Pharmaceuticals Limited Pharmaceutical compositions
CN110691596A (zh) * 2017-04-01 2020-01-14 阿德普蒂奥制药有限公司 药物组合物
GB201705303D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
WO2018200605A1 (en) * 2017-04-26 2018-11-01 Neurocrine Biosciences, Inc. Use of valbenazine for treating levodopa-induced dyskinesia
MA50175B1 (fr) 2017-09-21 2025-05-30 Neurocrine Biosciences, Inc. Formulation de valbenazine à dosage élevé et compositions, procédés et kits associés
KR20250070134A (ko) 2017-10-10 2025-05-20 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
AU2017435893B2 (en) 2017-10-10 2023-06-29 Neurocrine Biosciences, Inc Methods for the administration of certain VMAT2 inhibitors
WO2019094491A1 (en) * 2017-11-08 2019-05-16 Yuhua Li Esters of dihydrotetrabenazine
CA3086611C (en) 2017-12-26 2023-07-25 Crystal Pharmaceutical (Suzhou) Co., Ltd. A crystalline form of valbenazine ditosylate, processes for preparation thereof and use thereof
CA3097189A1 (en) * 2018-04-25 2019-10-31 Shinkei Therapeutics Llc Tetrabenazine transdermal delivery device
GB201808464D0 (en) 2018-05-23 2018-07-11 Adeptio Pharmaceuticals Ltd Pharmaceutical compounds for use in treating huntington's disease
WO2019241555A1 (en) 2018-06-14 2019-12-19 Neurocrine Biosciences, Inc. Vmat2 inhibitor compounds, compositions, and methods relating thereto
SG11202100303QA (en) 2018-08-15 2021-02-25 Neurocrine Biosciences Inc Methods for the administration of certain vmat2 inhibitors
WO2020070236A1 (en) 2018-10-04 2020-04-09 Adeptio Pharmaceuticals Limited (+)-alpha-dihydrotetrabenazine dosage regimen for treating movement disorders
JOP20210274A1 (ar) * 2019-05-09 2023-01-30 Neurocrine Biosciences Inc طرق لإعطاء مثبط vmat2 معين
US10940141B1 (en) * 2019-08-23 2021-03-09 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors

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JP2010509336A (ja) * 2006-11-09 2010-03-25 ニューヨーク ユニバーシティ サンドイッチ材料の製造方法、ガラス／セラミック／ガラス複合構造物、ガラス／セラミック／ガラス、医科あるいは歯科補綴、およびガラス／ジルコニア／ガラスサンドイッチ材料
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JP6362601B2 (ja) * 2012-09-18 2018-07-25 オースペックス・ファーマシューティカルズ・インコーポレイテッドＡｕｓｐｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 小胞モノアミン輸送体２の重水素化ベンゾキノリン阻害剤の製剤薬物動態
CN106061506A (zh) * 2014-02-07 2016-10-26 纽罗克里生物科学有限公司 包含抗精神病药物和vmat2抑制剂的药物组合物及其用途

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AU2015256012A1 (en) 2016-11-24
IL248745A0 (en) 2017-01-31
HUE066361T2 (hu) 2024-07-28
CA2947736A1 (en) 2015-11-12
CA2947736C (en) 2023-04-18
ES2904526T3 (es) 2022-04-05
MX387625B (es) 2025-03-18
CN106456629A (zh) 2017-02-22
JP2017514850A (ja) 2017-06-08
KR20200133003A (ko) 2020-11-25
PT3139925T (pt) 2022-01-26
EP4389227A2 (en) 2024-06-26
LT3936130T (lt) 2024-04-25
RU2016147523A3 (enExample) 2018-12-28
LT3139925T (lt) 2022-01-25
SMT202400199T1 (it) 2024-07-09
HUE057839T2 (hu) 2022-06-28
IL248745B (en) 2022-07-01
SI3936130T1 (sl) 2024-05-31
SI3139925T1 (sl) 2022-04-29
DK3139925T3 (da) 2021-12-20
JP2019218407A (ja) 2019-12-26
EP3139925B1 (en) 2021-12-01
HRP20220025T1 (hr) 2022-04-01
EP3936130A1 (en) 2022-01-12
EP3936130B1 (en) 2024-02-14
WO2015171802A1 (en) 2015-11-12
HRP20240459T1 (hr) 2024-06-21
JP6635945B2 (ja) 2020-01-29
SMT202200193T1 (it) 2022-07-21
US20200101063A1 (en) 2020-04-02
CY1125058T1 (el) 2023-06-09
RU2753740C2 (ru) 2021-08-23
US20170071932A1 (en) 2017-03-16
CN112741836A (zh) 2021-05-04
CN112741835A (zh) 2021-05-04
US20210196702A1 (en) 2021-07-01
JP2024153782A (ja) 2024-10-29
PL3936130T3 (pl) 2024-06-10
DK3936130T3 (da) 2024-03-25
JP2021191799A (ja) 2021-12-16
RS65359B1 (sr) 2024-04-30
EP3139925A1 (en) 2017-03-15
ES2976207T3 (es) 2024-07-26
KR20240011255A (ko) 2024-01-25
MX2016014429A (es) 2017-04-06
AU2015256012B2 (en) 2020-07-23
PL3139925T3 (pl) 2022-03-21
NZ725826A (en) 2023-05-26
PT3936130T (pt) 2024-04-17
EP4389227A3 (en) 2024-09-04
FI3936130T3 (fi) 2024-04-23
RU2016147523A (ru) 2018-06-08
KR20160147044A (ko) 2016-12-21
RS62782B1 (sr) 2022-01-31
KR20250029267A (ko) 2025-03-04

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