KR20220133246A - 류신 풍부 반복 키나아제 2 (LRRK2) iRNA 작용제 조성물 및 이의 사용 방법 - Google Patents

류신 풍부 반복 키나아제 2 (LRRK2) iRNA 작용제 조성물 및 이의 사용 방법 Download PDF

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KR20220133246A
KR20220133246A KR1020227029378A KR20227029378A KR20220133246A KR 20220133246 A KR20220133246 A KR 20220133246A KR 1020227029378 A KR1020227029378 A KR 1020227029378A KR 20227029378 A KR20227029378 A KR 20227029378A KR 20220133246 A KR20220133246 A KR 20220133246A
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nucleotides
dsrna agent
nucleotide
strand
antisense strand
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제임스 디. 맥키니치
제이슨 길버트
애덤 캐스토레노
란 티 호앙 당
새라 레블랑크
헤이얀 펑
캐럴램보스 케이태니스
망갈라 미낙시 사운다라판디안
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알닐람 파마슈티칼스 인코포레이티드
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KR1020227029378A 2020-01-24 2021-01-22 류신 풍부 반복 키나아제 2 (LRRK2) iRNA 작용제 조성물 및 이의 사용 방법 Pending KR20220133246A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062965452P 2020-01-24 2020-01-24
US62/965,452 2020-01-24
US202163138717P 2021-01-18 2021-01-18
US63/138,717 2021-01-18
PCT/US2021/014729 WO2021150969A1 (en) 2020-01-24 2021-01-22 LEUCINE-RICH REPEAT KINASE 2 (LRRK2) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF

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KR20220133246A true KR20220133246A (ko) 2022-10-04

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KR1020227029378A Pending KR20220133246A (ko) 2020-01-24 2021-01-22 류신 풍부 반복 키나아제 2 (LRRK2) iRNA 작용제 조성물 및 이의 사용 방법

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US (1) US20230126233A1 (https=)
EP (1) EP4093872A4 (https=)
JP (1) JP7826211B2 (https=)
KR (1) KR20220133246A (https=)
CN (1) CN115298312A (https=)
AU (1) AU2021211723A1 (https=)
BR (1) BR112022014590A2 (https=)
CA (1) CA3168871A1 (https=)
IL (1) IL294728A (https=)
MX (1) MX2022009026A (https=)
TW (1) TW202142690A (https=)
WO (1) WO2021150969A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4731763A1 (en) * 2023-06-20 2026-04-29 Adarx Pharmaceuticals, Inc. Lrrk2-modulating compositions and methods of use thereof
AU2024353921A1 (en) * 2023-09-27 2026-04-16 Neuro3 Therapeutics (Suzhou) Ltd. Novel sirna constructs, therapeutics, and modifications
CN120082552A (zh) * 2023-12-01 2025-06-03 艾码生物科技(南京)有限公司 初级-miRNA及其应用
TW202600826A (zh) * 2024-03-14 2026-01-01 大陸商上海拓界生物醫藥科技有限公司 靶向ＬＲＲＫ２的ＲＮＡｉ劑及其醫藥用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007124096A2 (en) * 2006-04-21 2007-11-01 The Trustees Of Columbia University In The City Of New York Lrrk2 regulaton of neuronal process morphology
WO2008091799A2 (en) * 2007-01-22 2008-07-31 The Trustees Of Columbia University In The City Of New York Cell-based methods for identifying inhibitors of parkinson's disease-associated lrrk2 mutants
GB201004475D0 (en) * 2010-03-17 2010-05-05 Isis Innovation Gene silencing
EA038792B1 (ru) * 2013-05-22 2021-10-20 Элнилэм Фармасьютикалз, Инк. КОМПОЗИЦИИ НА ОСНОВЕ RNAi Serpina1 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
WO2017087282A1 (en) * 2015-11-18 2017-05-26 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (lrrk2) for the treatment of parkinsons disease
TWI833770B (zh) 2018-06-27 2024-03-01 美商Ionis製藥公司 用於減少 lrrk2 表現之化合物及方法

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IL294728A (en) 2022-09-01
TW202142690A (zh) 2021-11-16
BR112022014590A2 (pt) 2022-09-13
MX2022009026A (es) 2022-08-11
JP2023511434A (ja) 2023-03-17
AU2021211723A1 (en) 2022-08-04
CA3168871A1 (en) 2021-07-29
WO2021150969A1 (en) 2021-07-29
EP4093872A4 (en) 2024-06-05
EP4093872A1 (en) 2022-11-30
CN115298312A (zh) 2022-11-04
WO2021150969A8 (en) 2022-01-06
JP7826211B2 (ja) 2026-03-09
US20230126233A1 (en) 2023-04-27

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