KR20220120844A - Herbal composition for preventing and treating tear stain and excessive tear in companion animals - Google Patents
Herbal composition for preventing and treating tear stain and excessive tear in companion animals Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims abstract description 30
- 241001465754 Metazoa Species 0.000 title claims abstract description 18
- 208000011580 syndromic disease Diseases 0.000 claims abstract description 21
- 238000010186 staining Methods 0.000 claims abstract description 15
- 229940124595 oriental medicine Drugs 0.000 claims description 15
- 235000007516 Chrysanthemum Nutrition 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 6
- 230000019612 pigmentation Effects 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- -1 tangjeon Substances 0.000 claims description 2
- 241000723353 Chrysanthemum Species 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 240000004713 Pisum sativum Species 0.000 claims 1
- 235000010582 Pisum sativum Nutrition 0.000 claims 1
- 241000282472 Canis lupus familiaris Species 0.000 abstract description 13
- 240000005250 Chrysanthemum indicum Species 0.000 abstract description 11
- 241000282326 Felis catus Species 0.000 abstract description 6
- 235000018959 Chrysanthemum indicum Nutrition 0.000 abstract description 2
- 241000405911 Rehmannia glutinosa Species 0.000 abstract 1
- 244000163122 Curcuma domestica Species 0.000 description 4
- 235000003392 Curcuma domestica Nutrition 0.000 description 4
- 235000003373 curcuma longa Nutrition 0.000 description 4
- 235000013976 turmeric Nutrition 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 210000004209 hair Anatomy 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 150000004032 porphyrins Chemical class 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 241000208838 Asteraceae Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
- 240000005595 Echinocereus dasyacanthus Species 0.000 description 1
- 235000008314 Echinocereus dasyacanthus Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 208000004262 Food Hypersensitivity Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010023644 Lacrimation increased Diseases 0.000 description 1
- 241000266501 Ormosia ormondii Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241000013557 Plantaginaceae Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 240000001717 Vaccinium macrocarpon Species 0.000 description 1
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 description 1
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 235000004634 cranberry Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000000720 eyelash Anatomy 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 235000020932 food allergy Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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Abstract
Description
본 발명은, 반려 동물의 눈물 자국 및 눈물 과다 증상 예방 및 치료용 한방 조성물에 관한 것이다.The present invention relates to an oriental medicine composition for preventing and treating tear marks and excessive tear symptoms in companion animals.
눈물 착색 증후군이란, 강아지, 고양이 등의 반려 동물에 있어서 눈물이 과다하게 분비되어 내안각 주위의 피부와 털이 암갈색 등으로 착색되는 증상으로, 미관상 좋지 않을 뿐만 아니라, 악취를 유발하는 원인이 된다. Tear pigmentation syndrome is a symptom in which excessive tears are secreted in companion animals such as dogs and cats and the skin and hair around the inner canthe are colored dark brown, etc.
강아지, 고양이 등의 반려 동물의 눈물에는 적혈구가 분해될 때 나오는 포르피린이라는 물질이 포함되어 있다. 포르피린은 다량의 철분을 함유하고 있기 때문에, 과도한 눈물은 털에 남아 산소와 접촉하여 붉은색으로 변하게 된다.The tears of companion animals such as dogs and cats contain a substance called porphyrin, which is released when red blood cells are broken down. Because porphyrins contain a large amount of iron, excess tears remain in the hair and turn red when it comes into contact with oxygen.
눈물 착색 증후군은 눈물 염색 증후군 또는 유루증이라 불리기도 하며, 그 원인으로는 눈물관의 막힘, 내안각내번증, 눈꺼풀, 속눈썹의 찌름, 식이 알러지 등으로 다양하다. Tear staining syndrome is also called tear staining syndrome or ecchymosis, and the causes are various, such as blockage of the tear duct, inner canthal inversion, stinging of the eyelids and eyelashes, and food allergies.
눈물 착색 증후군의 치료법은 그 원인에 따라 다르게 처치되는데, 눈물관의 막힘 등 눈물관에 문제가 있는 경우에는 눈물관개통술을 이용하여 눈물관을 세척하고, 내안각내번증의 경우 내안간성형술 등의 외과적 처치를 통해 치료한다. The treatment of lacrimal pigmentation syndrome is different depending on the cause. If there is a problem with the tear duct, such as blockage of the tear duct, the tear duct is cleaned using lacrimal duct surgery. treatment through
그 외 식이 알러지 등의 경우, 사료를 변경하거나 눈물 착색 증후군에 효과적인 첨가제를 급여한다. 이러한 첨가제 조성물로서, 타일로신 타르타르 조성물(특허공개공보 제10-2013-0046395호 참조), 소간의 분말과 크린베리 분말을 혼합한 조성물(특허공개공보 제10-2016-0003641호 참조) 등이 개시되어 있다.In other cases, such as dietary allergies, change the feed or provide an additive effective for tear staining syndrome. As such an additive composition, a tylosine tartar composition (refer to Patent Publication No. 10-2013-0046395), a composition obtained by mixing cow liver powder and cranberry powder (refer to Patent Publication No. 10-2016-0003641), etc. has been disclosed.
그러나, 눈물 착색 증후군 예방 및 치료를 위한 한방 조성물은 많이 개발되어 있지 않았으며, 유효 성분이 다양하게 첨가될수록 반려 동물에 따라 알러지 반응이 나타날 확률도 높아지기 때문에, 적은 종류의 유효 성분을 포함하면서 눈물 착색 증후군의 예방 및 치료 효과를 나타낼 수 있는 한방 조성물을 필요로 하고 있다.However, many herbal compositions for the prevention and treatment of tear pigmentation syndrome have not been developed, and the more the active ingredient is added, the higher the probability of an allergic reaction depending on the companion animal. There is a need for an oriental medicine composition that can exhibit preventive and therapeutic effects of the syndrome.
본 발명은, 강아지, 고양이 등의 반려 동물의 눈물 착색 증후군 예방 및 치료를 위한 한방 조성물을 제공하는 것을 목적으로 한다.An object of the present invention is to provide an oriental medicine composition for preventing and treating tear staining syndrome in companion animals such as dogs and cats.
본 발명은, 반려 동물 눈물 착색 증후군 예방 및 치료용 한방 조성물에 있어서, 건지황 및 감국을 포함하는 반려 동물 눈물 착색 증후군 예방 및 치료용 한방 조성물을 제공한다.The present invention provides an oriental medicine composition for preventing and treating tear staining syndrome in companion animals, comprising dry turmeric and chrysanthemum, in the oriental medicine composition for preventing and treating tear staining syndrome in companion animals.
상기 건지황 100중량부에 대해 감국 40 내지 60중량부를 포함할 수 있다. It may include 40 to 60 parts by weight of chrysanthemum with respect to 100 parts by weight of the dried yellow bean.
상기 한방 조성물은 분말, 탕전, 액상 및 환으로 이루어지는 군으로부터 선택된 어느 하나의 제형일 수 있다. The herbal composition may be in any one formulation selected from the group consisting of powder, tangjeon, liquid, and pills.
본 발명은, 건지황 및 감국을 포함하는 한방 조성물을 제공함으로써, 고양이, 강아지 등의 반려 동물의 눈물 착색 증후군을 예방 또는 치료할 수 있다.The present invention can prevent or treat tear staining syndrome in companion animals, such as cats and dogs, by providing an oriental medicine composition comprising geonjihwang and chrysanthemum.
이하, 본 발명의 구현예를 상세히 설명하기로 한다. 다만, 이는 예시로서 제시되는 것으로, 이에 의해 본 발명이 제한되지는 않으며 본 발명은 후술할 청구항의 범주에 의해 정의될 뿐이다.Hereinafter, embodiments of the present invention will be described in detail. However, this is presented as an example, and the present invention is not limited thereto, and the present invention is only defined by the scope of the claims to be described later.
본 발명의 일 구현예에 따른 한방 조성물은 건지황 및 감국을 포함하는 반려 동물 눈물 착색 증후군 예방 및 치료용 한방 조성물이다.The oriental medicine composition according to an embodiment of the present invention is an oriental medicine composition for preventing and treating companion animal tear staining syndrome, including dried turmeric and chrysanthemum.
본 발명에서 반려 동물은 강아지, 고양이 등이며, 특히 강아지가 바람직하고, 말티즈, 페니키즈, 치와와 또는 요크셔테리어 등 눈물 착색 증후군이 빈번하게 발생하는 소형 견종이 특히 바람직하다.In the present invention, the companion animal is a puppy, a cat, etc., particularly preferably a puppy, and particularly preferably a small dog breed that frequently suffers from tear staining syndrome, such as a Maltese, Phoenician, Chihuahua or Yorkshire Terrier.
본 발명에서 건지황(乾地黃, Rehmanniae Radix)이란, 지황(Rehmanniaeglutinosa)의 뿌리를 건조한 것으로, 지황은 현삼과(Scrophulariaceae)에 속하는 다년생 초본이다.In the present invention, Geonjihwang (乾地黃, Rehmanniae Radix) is a dried root of Rehmanniaeglutinosa, and Rehmanniae is a perennial herb belonging to the family Scrophulariaceae.
본 발명에서 감국(Chrysanthemum indicum)이란, 국화과의 식물로서, 황국(黃菊)이라고도 하고, 한국, 타이완, 중국, 일본 등지에 분포한다. 꽃을 말려서 술에 넣어 마시고, 어린 잎은 나물로 쓰며, 꽃에는 진한 향기가 있어 관상용으로도 가꾼다. 한방에서 감기, 폐렴, 기관지염, 두통, 위염, 장염, 종기 등의 치료에 처방한다. 민간요법으로는 풀 전체를 짓찧어서 환부에 붙이거나 생초를 달인 물로 환부를 씻어내어 사용한다.In the present invention, Chrysanthemum indicum is a plant of the Asteraceae family, also called Hwangguk (黃菊), and is distributed in Korea, Taiwan, China, Japan, and the like. The flowers are dried and drunk, and the young leaves are used as herbs, and the flowers have a strong fragrance, so they are also cultivated for ornamental purposes. In oriental medicine, it is prescribed for the treatment of colds, pneumonia, bronchitis, headache, gastritis, enteritis, and boils. For folk remedies, crush the whole grass and attach it to the affected area, or wash the affected area with decoction of fresh herbs.
본 발명의 한방 조성물은, 건지황 100중량부에 대해 감국 40중량부 내지 60중량부를 포함하고 있으며, 바람직하게는 건지황 100중량부에 대해 감국 50중량부를 포함한다. The oriental medicine composition of the present invention contains 40 parts by weight to 60 parts by weight of chrysanthemum based on 100 parts by weight of dried sulfur, preferably 50 parts by weight of chrysanthemum with respect to 100 parts by weight of dried yellow chrysanthemum.
실시예Example
이하, 실시예를 들어 본 발명을 자세히 설명한다. 실시예는 본 발명의 이해를 돕기 위하여 나타낸 것으로, 본 발명이 실시예에 의해 한정적으로 해석되어서는 안된다.Hereinafter, the present invention will be described in detail with reference to Examples. The examples are presented to help the understanding of the present invention, and the present invention should not be construed as being limited by the examples.
실시예 1 : 분말 형태의 조성물Example 1: Composition in powder form
물 2L에 건지황 100g 및 감국 50g을 첨가하여 혼합하고, 처음 1시간은 센불로 가열하고 이후 2시간은 약한 불로 가열하여 총 3시간을 달이고 추출하여 한약재 추출물을 제조한다.100 g of dried turmeric and 50 g of chrysanthemum are added to 2L of water and mixed, heated over high heat for the first 1 hour, and then heated over low heat for 2 hours, decoction and extraction for a total of 3 hours to prepare a herbal medicine extract.
추출된 한약재 추출물을 여과, 동결 건조시키고 분쇄하여 분말 형태의 조성물을 제조한다.The extracted herbal medicine extract is filtered, freeze-dried and pulverized to prepare a composition in powder form.
실시예 2 : 액상 형태의 조성물Example 2: Composition in liquid form
1첩을 물 250 ml 기준으로 하여, 총 20첩 분량의 탕약을 제조하기 위해, 물 5 L에 건지황 100g 및 감국 50g을 첨가하고, 105℃에서 150분간 탕전하여 액상 형태의 조성물을 제조하였다(총 45팩, 100 ml/팩).To prepare a decoction for a total of 20 cheops based on 250 ml of water, 100 g of dried turmeric and 50 g of chrysanthemum were added to 5 L of water, and boiled at 105 ° C. for 150 minutes to prepare a liquid composition (total 45 packs, 100 ml/pack).
상기 실시예 1에서 제조된 조성물을 눈물 착색 증후군에 의해 눈 주위가 착색된 반려견 30마리를 대상으로, 반려견 주인의 동의를 받아 3개월 동안 급여하였다. 평가 기준은 반려견의 눈물로 인한 착색과 악취에 대한 피실험자(반려견 주인)와 실험자(의료인)이 VAS(Visual Analogue Scale)로 측정하였고, 착색과 악취가 전혀 없는 상태를 0점, 착색과 악취가 매우 심한 상태를 10점으로 하여 측정하였다.The composition prepared in Example 1 was fed to 30 dogs whose eyes were colored by tear pigmentation syndrome for 3 months with the consent of the dog owner. As for the evaluation criteria, the test subject (dog owner) and the experimenter (medical person) for coloration and odor caused by dog tears were measured by VAS (Visual Analogue Scale). Severe condition was measured as 10 points.
급여 1개월 후 및 3개월 후 두 번에 걸쳐 동일한 방식으로 측정하였으며, 그 결과를 하기 표 1에 나타낸다.It was measured in the same manner twice after 1 month and 3 months after salary, and the results are shown in Table 1 below.
위 표에 나타낸 바와 같이, 반려견을 대상으로 급여한 결과, 피실험자 및 실험자 모두 반려견의 눈물로 인한 착색과 악취가 감소되었다고 평가하였다. 또한, 유효 성분으로서 2가지의 성분만을 포함하고 있기 때문에, 대상 반려견 중 어느 반려견에서도 알러지 등 부작용이 발생하지 않았다.As shown in the table above, as a result of feeding dogs, both the test subject and the experimenter evaluated that the coloration and odor caused by the dog's tears were reduced. In addition, since it contains only two ingredients as active ingredients, side effects such as allergies did not occur in any of the target dogs.
Claims (3)
건지황 및 감국을 포함하는 반려 동물 눈물 착색 증후군 예방 및 치료용 한방 조성물.In the oriental medicine composition for preventing and treating companion animal tear staining syndrome,
An oriental medicine composition for the prevention and treatment of tear staining syndrome in companion animals, comprising Geonjihwang and Chrysanthemum.
상기 건지황 100중량부에 대해 감국 40 내지 60중량부를 포함하는, 반려 동물 눈물 착색 증후군 예방 및 치료용 한방 조성물. The method of claim 1,
Comprising 40 to 60 parts by weight of chrysanthemum with respect to 100 parts by weight of the dried yellow peas, an oriental medicine composition for the prevention and treatment of tear pigmentation syndrome in companion animals.
상기 한방 조성물은 분말, 탕전, 액상 및 환으로 이루어지는 군으로부터 선택된 어느 하나의 제형인, 반려 동물 눈물 착색 증후군 예방 및 치료용 한방 조성물.
3. The method according to claim 1 or 2,
The oriental medicine composition is any one formulation selected from the group consisting of powder, tangjeon, liquid and pills, an oriental medicine composition for preventing and treating companion animal tear staining syndrome.
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KR102117357B1 (en) * | 2020-02-13 | 2020-06-01 | (주)피엘씨 | Oriental medicine based synthetic nutrition snack composition for dog |
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