KR102608832B1 - Herbal composition for preventing and treating tear stain and excessive tear in companion animals - Google Patents
Herbal composition for preventing and treating tear stain and excessive tear in companion animals Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 241001465754 Metazoa Species 0.000 title abstract description 11
- 238000010186 staining Methods 0.000 claims abstract description 17
- 208000011580 syndromic disease Diseases 0.000 claims abstract description 17
- 241000723353 Chrysanthemum Species 0.000 claims abstract description 13
- 241000405911 Rehmannia glutinosa Species 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 4
- 235000007516 Chrysanthemum Nutrition 0.000 claims description 3
- 241000411851 herbal medicine Species 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims 2
- 238000009835 boiling Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 238000010298 pulverizing process Methods 0.000 claims 1
- 241000282472 Canis lupus familiaris Species 0.000 abstract description 15
- 241000282326 Felis catus Species 0.000 abstract description 6
- 241000405414 Rehmannia Species 0.000 abstract description 4
- 238000002845 discoloration Methods 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 150000004032 porphyrins Chemical class 0.000 description 2
- 241000208838 Asteraceae Species 0.000 description 1
- 240000005250 Chrysanthemum indicum Species 0.000 description 1
- 235000018959 Chrysanthemum indicum Nutrition 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 240000005595 Echinocereus dasyacanthus Species 0.000 description 1
- 235000008314 Echinocereus dasyacanthus Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 206010061842 Entropion Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000004262 Food Hypersensitivity Diseases 0.000 description 1
- 208000001287 Galactorrhea Diseases 0.000 description 1
- 206010017600 Galactorrhoea Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010023644 Lacrimation increased Diseases 0.000 description 1
- 241000013557 Plantaginaceae Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 239000004182 Tylosin Substances 0.000 description 1
- 229930194936 Tylosin Natural products 0.000 description 1
- 240000001717 Vaccinium macrocarpon Species 0.000 description 1
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 description 1
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 235000021336 beef liver Nutrition 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 235000004634 cranberry Nutrition 0.000 description 1
- -1 decoction Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 201000004356 excessive tearing Diseases 0.000 description 1
- 210000000720 eyelash Anatomy 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 235000020932 food allergy Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 229940124595 oriental medicine Drugs 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 1
- 229960004059 tylosin Drugs 0.000 description 1
- 235000019375 tylosin Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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Abstract
본 발명은, 강아지, 고양이 등의 반려 동물의 눈물 착색 증후군 예방 및 치료를 위한 한방 조성물을 제공하는 것을 목적으로 한다. 본 발명은, 반려 동물 눈물 착색 증후군 예방 및 치료용 한방 조성물에 있어서, 건지황 및 감국을 포함하는 반려 동물 눈물 착색 증후군 예방 및 치료용 한방 조성물을 제공한다.The purpose of the present invention is to provide an herbal composition for preventing and treating tear staining syndrome in companion animals such as dogs and cats. The present invention provides an herbal composition for preventing and treating tear staining syndrome in companion animals, including dried rehmannia root and chrysanthemum chrysanthemum.
Description
본 발명은, 반려 동물의 눈물 자국 및 눈물 과다 증상 예방 및 치료용 한방 조성물에 관한 것이다.The present invention relates to an herbal composition for preventing and treating tear stains and excessive tearing symptoms in companion animals.
눈물 착색 증후군이란, 강아지, 고양이 등의 반려 동물에 있어서 눈물이 과다하게 분비되어 내안각 주위의 피부와 털이 암갈색 등으로 착색되는 증상으로, 미관상 좋지 않을 뿐만 아니라, 악취를 유발하는 원인이 된다. Tear staining syndrome is a condition in which excessive secretion of tears occurs in companion animals such as dogs and cats, causing the skin and fur around the inner canthus to become discolored, such as dark brown. Not only is it unsightly, but it also causes a bad odor.
강아지, 고양이 등의 반려 동물의 눈물에는 적혈구가 분해될 때 나오는 포르피린이라는 물질이 포함되어 있다. 포르피린은 다량의 철분을 함유하고 있기 때문에, 과도한 눈물은 털에 남아 산소와 접촉하여 붉은색으로 변하게 된다.The tears of companion animals such as dogs and cats contain a substance called porphyrin, which is released when red blood cells are broken down. Because porphyrin contains a large amount of iron, excess tears remain in the fur and turn red when exposed to oxygen.
눈물 착색 증후군은 눈물 염색 증후군 또는 유루증이라 불리기도 하며, 그 원인으로는 눈물관의 막힘, 내안각내번증, 눈꺼풀, 속눈썹의 찌름, 식이 알러지 등으로 다양하다. Tear staining syndrome is also called tear staining syndrome or galactorrhea, and its causes include blockage of the tear duct, medial canthus entropion, pricking of the eyelids and eyelashes, and food allergies.
눈물 착색 증후군의 치료법은 그 원인에 따라 다르게 처치되는데, 눈물관의 막힘 등 눈물관에 문제가 있는 경우에는 눈물관개통술을 이용하여 눈물관을 세척하고, 내안각내번증의 경우 내안간성형술 등의 외과적 처치를 통해 치료한다. Treatment for tear staining syndrome varies depending on the cause. If there is a problem with the tear duct, such as a blockage of the tear duct, tear duct recanalization is used to clean the tear duct. In the case of medial canthal inversion, surgical treatment such as medial canthalplasty is performed. Treated through
그 외 식이 알러지 등의 경우, 사료를 변경하거나 눈물 착색 증후군에 효과적인 첨가제를 급여한다. 이러한 첨가제 조성물로서, 타일로신 타르타르 조성물(특허공개공보 제10-2013-0046395호 참조), 소간의 분말과 크린베리 분말을 혼합한 조성물(특허공개공보 제10-2016-0003641호 참조) 등이 개시되어 있다.In other cases, such as dietary allergies, change the feed or feed additives effective for tear staining syndrome. As such additive compositions, tylosin tartar composition (see Patent Publication No. 10-2013-0046395), a composition mixing beef liver powder and cranberry powder (see Patent Publication No. 10-2016-0003641), etc. It has been disclosed.
그러나, 눈물 착색 증후군 예방 및 치료를 위한 한방 조성물은 많이 개발되어 있지 않았으며, 유효 성분이 다양하게 첨가될수록 반려 동물에 따라 알러지 반응이 나타날 확률도 높아지기 때문에, 적은 종류의 유효 성분을 포함하면서 눈물 착색 증후군의 예방 및 치료 효과를 나타낼 수 있는 한방 조성물을 필요로 하고 있다.However, not many herbal compositions for the prevention and treatment of tear staining syndrome have been developed, and the more diverse active ingredients are added, the higher the probability of allergic reactions depending on the pet. Therefore, tear staining while containing a small number of active ingredients is possible. There is a need for an herbal composition that can prevent and treat the syndrome.
본 발명은, 강아지, 고양이 등의 반려 동물의 눈물 착색 증후군 예방 및 치료를 위한 한방 조성물을 제공하는 것을 목적으로 한다.The purpose of the present invention is to provide an herbal composition for preventing and treating tear staining syndrome in companion animals such as dogs and cats.
본 발명은, 반려 동물 눈물 착색 증후군 예방 및 치료용 한방 조성물에 있어서, 건지황 및 감국을 포함하는 반려 동물 눈물 착색 증후군 예방 및 치료용 한방 조성물을 제공한다.The present invention provides an herbal composition for preventing and treating tear staining syndrome in companion animals, including dried rehmannia root and chrysanthemum chrysanthemum.
상기 건지황 100중량부에 대해 감국 40 내지 60중량부를 포함할 수 있다. It may include 40 to 60 parts by weight of chrysanthemum per 100 parts by weight of dried rehmannia glutinosa.
상기 한방 조성물은 분말, 탕전, 액상 및 환으로 이루어지는 군으로부터 선택된 어느 하나의 제형일 수 있다. The herbal composition may be any one formulation selected from the group consisting of powder, decoction, liquid, and pill.
본 발명은, 건지황 및 감국을 포함하는 한방 조성물을 제공함으로써, 고양이, 강아지 등의 반려 동물의 눈물 착색 증후군을 예방 또는 치료할 수 있다.The present invention can prevent or treat tear staining syndrome in companion animals such as cats and dogs by providing an herbal composition containing dried rehmannia root and chrysanthemum chrysanthemum.
이하, 본 발명의 구현예를 상세히 설명하기로 한다. 다만, 이는 예시로서 제시되는 것으로, 이에 의해 본 발명이 제한되지는 않으며 본 발명은 후술할 청구항의 범주에 의해 정의될 뿐이다.Hereinafter, embodiments of the present invention will be described in detail. However, this is presented as an example, and the present invention is not limited thereby, and the present invention is only defined by the scope of the claims to be described later.
본 발명의 일 구현예에 따른 한방 조성물은 건지황 및 감국을 포함하는 반려 동물 눈물 착색 증후군 예방 및 치료용 한방 조성물이다.The herbal composition according to one embodiment of the present invention is an herbal composition for preventing and treating tear staining syndrome in companion animals, including dried rehmannia root and chrysanthemum chrysanthemum.
본 발명에서 반려 동물은 강아지, 고양이 등이며, 특히 강아지가 바람직하고, 말티즈, 페니키즈, 치와와 또는 요크셔테리어 등 눈물 착색 증후군이 빈번하게 발생하는 소형 견종이 특히 바람직하다.In the present invention, the companion animal is a dog, a cat, etc., and dogs are particularly preferable, and small dog breeds such as Maltese, Pennywise, Chihuahua, or Yorkshire Terrier, which frequently cause tear staining syndrome, are particularly preferable.
본 발명에서 건지황(乾地黃, Rehmanniae Radix)이란, 지황(Rehmanniaeglutinosa)의 뿌리를 건조한 것으로, 지황은 현삼과(Scrophulariaceae)에 속하는 다년생 초본이다.In the present invention, dried Rehmanniae Radix refers to the dried roots of Rehmanniaeglutinosa, which is a perennial herb belonging to the Scrophulariaceae family.
본 발명에서 감국(Chrysanthemum indicum)이란, 국화과의 식물로서, 황국(黃菊)이라고도 하고, 한국, 타이완, 중국, 일본 등지에 분포한다. 꽃을 말려서 술에 넣어 마시고, 어린 잎은 나물로 쓰며, 꽃에는 진한 향기가 있어 관상용으로도 가꾼다. 한방에서 감기, 폐렴, 기관지염, 두통, 위염, 장염, 종기 등의 치료에 처방한다. 민간요법으로는 풀 전체를 짓찧어서 환부에 붙이거나 생초를 달인 물로 환부를 씻어내어 사용한다.In the present invention, Chrysanthemum indicum is a plant of the Asteraceae family, is also called yellow chrysanthemum, and is distributed in Korea, Taiwan, China, Japan, etc. The flowers are dried and put into alcohol, the young leaves are used as an herb, and the flowers have a strong scent, so they are also grown for ornamental purposes. In oriental medicine, it is prescribed for the treatment of colds, pneumonia, bronchitis, headache, gastritis, enteritis, and boils. As a folk remedy, crush the whole herb and apply it to the affected area or wash the affected area with water made from decocted raw herb.
본 발명의 한방 조성물은, 건지황 100중량부에 대해 감국 40중량부 내지 60중량부를 포함하고 있으며, 바람직하게는 건지황 100중량부에 대해 감국 50중량부를 포함한다. The herbal composition of the present invention contains 40 to 60 parts by weight of chrysanthemum chrysanthemum per 100 parts by weight of dried rehmannia glutinosa, and preferably contains 50 parts by weight of chrysanthemum chrysanthemum per 100 parts by weight of dried rehmannia glutinosa.
실시예Example
이하, 실시예를 들어 본 발명을 자세히 설명한다. 실시예는 본 발명의 이해를 돕기 위하여 나타낸 것으로, 본 발명이 실시예에 의해 한정적으로 해석되어서는 안된다.Hereinafter, the present invention will be described in detail through examples. The examples are shown to aid understanding of the present invention, and the present invention should not be construed as limited by the examples.
실시예 1 : 분말 형태의 조성물Example 1: Composition in powder form
물 2L에 건지황 100g 및 감국 50g을 첨가하여 혼합하고, 처음 1시간은 센불로 가열하고 이후 2시간은 약한 불로 가열하여 총 3시간을 달이고 추출하여 한약재 추출물을 제조한다.Add 100g of dried rehmannia glutinosa and 50g of chrysanthemum chrysanthemum to 2L of water, mix, heat over high heat for the first hour, then over low heat for the next 2 hours, boil and extract for a total of 3 hours to prepare herbal medicine extract.
추출된 한약재 추출물을 여과, 동결 건조시키고 분쇄하여 분말 형태의 조성물을 제조한다.The extracted herbal medicine extract is filtered, freeze-dried, and pulverized to prepare a composition in powder form.
실시예 2 : 액상 형태의 조성물Example 2: Composition in liquid form
1첩을 물 250 ml 기준으로 하여, 총 20첩 분량의 탕약을 제조하기 위해, 물 5 L에 건지황 100g 및 감국 50g을 첨가하고, 105℃에서 150분간 탕전하여 액상 형태의 조성물을 제조하였다(총 45팩, 100 ml/팩).In order to prepare a total of 20 cups of decoction based on 250 ml of water, 100 g of dried rehmannia glutinosa and 50 g of chrysanthemum chrysanthemum were added to 5 L of water and boiled at 105°C for 150 minutes to prepare a composition in liquid form (total: 45 packs, 100 ml/pack).
상기 실시예 1에서 제조된 조성물을 눈물 착색 증후군에 의해 눈 주위가 착색된 반려견 30마리를 대상으로, 반려견 주인의 동의를 받아 3개월 동안 급여하였다. 평가 기준은 반려견의 눈물로 인한 착색과 악취에 대한 피실험자(반려견 주인)와 실험자(의료인)이 VAS(Visual Analogue Scale)로 측정하였고, 착색과 악취가 전혀 없는 상태를 0점, 착색과 악취가 매우 심한 상태를 10점으로 하여 측정하였다.The composition prepared in Example 1 was administered to 30 dogs with pigmentation around the eyes due to tear staining syndrome for 3 months with the consent of the dog owners. The evaluation standard was a Visual Analogue Scale (VAS) measured by the subject (dog owner) and the experimenter (medical professional) for discoloration and odor caused by the dog's tears, with 0 being completely free of discoloration and odor, and 0 being very discoloration and odor. Severe condition was rated at 10 points.
급여 1개월 후 및 3개월 후 두 번에 걸쳐 동일한 방식으로 측정하였으며, 그 결과를 하기 표 1에 나타낸다.Measurements were made in the same manner twice, one month and three months after payment, and the results are shown in Table 1 below.
위 표에 나타낸 바와 같이, 반려견을 대상으로 급여한 결과, 피실험자 및 실험자 모두 반려견의 눈물로 인한 착색과 악취가 감소되었다고 평가하였다. 또한, 유효 성분으로서 2가지의 성분만을 포함하고 있기 때문에, 대상 반려견 중 어느 반려견에서도 알러지 등 부작용이 발생하지 않았다.As shown in the table above, as a result of feeding to dogs, both the test subject and the experimenter evaluated that the discoloration and bad smell caused by the dogs' tears were reduced. Additionally, because it contains only two active ingredients, no side effects such as allergies occurred in any of the target dogs.
Claims (3)
건지황 100중량부에 대해 감국 50중량부를 포함하는 것을 특징으로 하고,
상기 한방 조성물은 상기 건지황, 감국 및 물을 혼합하여 1시간 동안 가열하고, 2시간 동안 추가로 가열하여 얻어진 한약재 추출물을 여과 및 동결 건조시킨 다음 분쇄한 분말 형태이거나,
상기 건지황, 감국 및 물을 혼합하여 105℃에서 탕전하여 제조된 액상 형태인 것을 특징으로 하는, 반려 동물 눈물 착색 증후군 예방 또는 치료용 한방 조성물.In the herbal composition for preventing or treating pet tear staining syndrome,
It is characterized in that it contains 50 parts by weight of chrysanthemum per 100 parts by weight of dried rehmannia glutinosa,
The herbal composition is in the form of a powder obtained by mixing the dried rehmannia glutinosa, chrysanthemum chrysanthemum, and water, heating for 1 hour, and further heating for 2 hours, filtering, freeze-drying, and pulverizing the herbal medicine extract, or
An herbal composition for preventing or treating pet tear staining syndrome, characterized in that it is in a liquid form prepared by mixing the dried rehmannia glutinosa, chrysanthemum chrysanthemum, and water and boiling at 105°C.
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