KR20220119730A - 인슐린 유도체 - Google Patents

인슐린 유도체 Download PDF

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Publication number
KR20220119730A
KR20220119730A KR1020227026305A KR20227026305A KR20220119730A KR 20220119730 A KR20220119730 A KR 20220119730A KR 1020227026305 A KR1020227026305 A KR 1020227026305A KR 20227026305 A KR20227026305 A KR 20227026305A KR 20220119730 A KR20220119730 A KR 20220119730A
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KR
South Korea
Prior art keywords
human insulin
γglu
desb30 human
insulin
docosandioyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020227026305A
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English (en)
Korean (ko)
Inventor
종루 간
웨이 천
이닝 장
팡카이 슈에
링위 차이
지앙홍 니우
빈 무
Original Assignee
간 앤 리 파마슈티칼스 컴퍼니, 리미티드
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Application filed by 간 앤 리 파마슈티칼스 컴퍼니, 리미티드 filed Critical 간 앤 리 파마슈티칼스 컴퍼니, 리미티드
Publication of KR20220119730A publication Critical patent/KR20220119730A/ko
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020227026305A 2019-12-30 2020-12-29 인슐린 유도체 Pending KR20220119730A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201911398378 2019-12-30
CN201911398378.0 2019-12-30
CN202011057926.6 2020-09-29
CN202011057926 2020-09-29
PCT/CN2020/141023 WO2021136296A1 (zh) 2019-12-30 2020-12-29 胰岛素衍生物

Publications (1)

Publication Number Publication Date
KR20220119730A true KR20220119730A (ko) 2022-08-30

Family

ID=76687317

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020227026305A Pending KR20220119730A (ko) 2019-12-30 2020-12-29 인슐린 유도체
KR1020227024018A Pending KR20220121833A (ko) 2019-12-30 2020-12-29 인슐린 유도체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020227024018A Pending KR20220121833A (ko) 2019-12-30 2020-12-29 인슐린 유도체

Country Status (10)

Country Link
US (5) US20240025957A1 (enExample)
EP (3) EP4086278A4 (enExample)
JP (3) JP2023510219A (enExample)
KR (2) KR20220119730A (enExample)
CN (12) CN118754967A (enExample)
AU (2) AU2020418205A1 (enExample)
BR (2) BR112022013150A2 (enExample)
CA (2) CA3166495A1 (enExample)
MX (2) MX2022008130A (enExample)
WO (3) WO2021136293A1 (enExample)

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Publication number Priority date Publication date Assignee Title
CN118754967A (zh) * 2019-12-30 2024-10-11 甘李药业股份有限公司 胰岛素衍生物
EP4086277A4 (en) * 2019-12-30 2024-02-14 Gan & Lee Pharmaceuticals Co., Ltd. Long-acting glp-1 compound
CA3204051A1 (en) 2021-01-20 2022-07-28 Brian Lian Compositions and methods for the treatment of metabolic and liver disorders
CN115385843A (zh) * 2021-05-24 2022-11-25 广东东阳光药业有限公司 一种新型的酰化胰岛素类似物
AU2022300061A1 (en) * 2021-06-25 2024-02-01 Gan & Lee Pharmaceuticals Co., Ltd. Acylated insulin-containing pharmaceutical composition
JP7642830B2 (ja) 2021-09-15 2025-03-10 バイキング・セラピューティクス・インコーポレイテッド 代謝及び肝臓障害の処置のための組成物及び方法
CN116162147B (zh) * 2021-11-24 2023-10-03 成都奥达生物科技有限公司 一种长效胰岛素类似物
US20250340610A1 (en) * 2022-01-28 2025-11-06 Gan & Lee Pharmaceuticals Co., Ltd. Acylated insulin
WO2024179606A1 (zh) * 2023-03-02 2024-09-06 甘李药业股份有限公司 一种glp-1化合物的医药用途
CN121219311A (zh) * 2023-05-24 2025-12-26 联邦生物科技(珠海横琴)有限公司 一种胰岛素衍生物及其应用
CN116327890B (zh) * 2023-05-29 2023-12-08 北京先为达生物科技有限公司 口服递送的组合物及其应用
CN116789801B (zh) * 2023-08-21 2023-11-14 南京赛诺生物技术有限公司 新型胰岛素衍生物及其用途
WO2025077751A1 (zh) * 2023-10-09 2025-04-17 甘李药业股份有限公司 Glp-1肽组合物及其用途
WO2025098457A1 (zh) * 2023-11-07 2025-05-15 甘李药业股份有限公司 用于降糖的酰化胰岛素
WO2025098502A1 (zh) * 2023-11-08 2025-05-15 甘李药业股份有限公司 包含胰岛素衍生物的药物组合物的治疗用途
WO2025228255A1 (zh) * 2024-04-28 2025-11-06 正大天晴药业集团股份有限公司 酰化人胰岛素类似物

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PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK336188D0 (da) 1988-06-20 1988-06-20 Nordisk Gentofte Propeptider
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IL93282A (en) 1989-02-09 1995-08-31 Lilly Co Eli Insulin analogues
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CN104364260B (zh) 2012-04-11 2017-02-22 诺和诺德股份有限公司 胰岛素制剂
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AR099569A1 (es) * 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
CN105820233B (zh) 2015-01-04 2021-06-15 甘李药业股份有限公司 一种胰岛素衍生物的制备方法
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ES2908373T3 (es) * 2015-08-25 2022-04-28 Novo Nordisk As Nuevos derivados de insulina y los usos médicos de los mismos
PL3341991T3 (pl) * 2015-08-27 2020-11-30 Haldor Topsøe A/S Materiał aktywny litowej elektrody dodatniej o wysokiej gęstości nasypowej z usadem, półprodukt i sposób wytwarzania
WO2018024186A1 (zh) 2016-08-02 2018-02-08 江苏恒瑞医药股份有限公司 一种人胰岛素或其类似物的酰化衍生物
PE20210857A1 (es) 2016-12-16 2021-05-18 Novo Nordisk As Composiciones farmaceuticas que contienen insulina
JOP20190273A1 (ar) 2017-05-26 2019-11-24 Lilly Co Eli مركب إنسولين معالج بأسيل
CN118754967A (zh) * 2019-12-30 2024-10-11 甘李药业股份有限公司 胰岛素衍生物
EP4086277A4 (en) * 2019-12-30 2024-02-14 Gan & Lee Pharmaceuticals Co., Ltd. Long-acting glp-1 compound
US20250340610A1 (en) * 2022-01-28 2025-11-06 Gan & Lee Pharmaceuticals Co., Ltd. Acylated insulin

Also Published As

Publication number Publication date
CN114901682A (zh) 2022-08-12
CN118206632A (zh) 2024-06-18
MX2022008130A (es) 2022-10-03
US20250032589A1 (en) 2025-01-30
CN114901683A (zh) 2022-08-12
US20250228919A1 (en) 2025-07-17
JP2023510219A (ja) 2023-03-13
BR112022013150A2 (pt) 2023-02-28
CA3166494A1 (en) 2021-07-08
CN114901682B (zh) 2024-04-16
BR112022013009A2 (pt) 2022-09-06
EP4086279A1 (en) 2022-11-09
US20240239862A1 (en) 2024-07-18
WO2021136296A1 (zh) 2021-07-08
EP4086278A1 (en) 2022-11-09
AU2020418205A1 (en) 2022-08-04
CN114901681B (zh) 2024-04-09
CN114901681A (zh) 2022-08-12
WO2021136302A1 (zh) 2021-07-08
KR20220121833A (ko) 2022-09-01
EP4086280A1 (en) 2022-11-09
CN118754967A (zh) 2024-10-11
CN118598978A (zh) 2024-09-06
CN114901683B (zh) 2024-09-13
US20240025957A1 (en) 2024-01-25
CN118420743A (zh) 2024-08-02
AU2020417892A1 (en) 2022-08-25
JP2023510206A (ja) 2023-03-13
WO2021136293A1 (zh) 2021-07-08
CN118480114A (zh) 2024-08-13
EP4086280A4 (en) 2024-05-29
US12576136B2 (en) 2026-03-17
EP4086279A4 (en) 2024-08-07
CA3166495A1 (en) 2021-07-08
CN118420744A (zh) 2024-08-02
JP2025161829A (ja) 2025-10-24
MX2022008174A (es) 2022-08-02
US20230126068A1 (en) 2023-04-27
CN118666989A (zh) 2024-09-20
EP4086278A4 (en) 2024-08-07
CN118772259A (zh) 2024-10-15
CN118894922A (zh) 2024-11-05

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