JP2023510219A - インスリン誘導体 - Google Patents

インスリン誘導体 Download PDF

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Publication number
JP2023510219A
JP2023510219A JP2022540871A JP2022540871A JP2023510219A JP 2023510219 A JP2023510219 A JP 2023510219A JP 2022540871 A JP2022540871 A JP 2022540871A JP 2022540871 A JP2022540871 A JP 2022540871A JP 2023510219 A JP2023510219 A JP 2023510219A
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JP
Japan
Prior art keywords
human insulin
γglu
desb30 human
insulin
eicosanediacyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022540871A
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English (en)
Japanese (ja)
Other versions
JP2023510219A5 (enExample
Inventor
ガン，ジョォンルー
チェン，ウェイ
ジャン，イイニン
シュエ，ファンカイ
ツァイ，リンギュ
ニィウ，ジァンホン
ム，ビン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gan and Lee Pharmaceuticals Co Ltd
Original Assignee
Gan and Lee Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gan and Lee Pharmaceuticals Co Ltd filed Critical Gan and Lee Pharmaceuticals Co Ltd
Publication of JP2023510219A publication Critical patent/JP2023510219A/ja
Publication of JP2023510219A5 publication Critical patent/JP2023510219A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2022540871A 2019-12-30 2020-12-29 インスリン誘導体 Pending JP2023510219A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201911398378 2019-12-30
CN201911398378.0 2019-12-30
CN202011057926.6 2020-09-29
CN202011057926 2020-09-29
PCT/CN2020/141023 WO2021136296A1 (zh) 2019-12-30 2020-12-29 胰岛素衍生物

Publications (2)

Publication Number Publication Date
JP2023510219A true JP2023510219A (ja) 2023-03-13
JP2023510219A5 JP2023510219A5 (enExample) 2026-01-21

Family

ID=76687317

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2022540871A Pending JP2023510219A (ja) 2019-12-30 2020-12-29 インスリン誘導体
JP2022540767A Pending JP2023510206A (ja) 2019-12-30 2020-12-29 インスリン誘導体
JP2025128114A Pending JP2025161829A (ja) 2019-12-30 2025-07-31 インスリン誘導体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022540767A Pending JP2023510206A (ja) 2019-12-30 2020-12-29 インスリン誘導体
JP2025128114A Pending JP2025161829A (ja) 2019-12-30 2025-07-31 インスリン誘導体

Country Status (10)

Country Link
US (5) US20240025957A1 (enExample)
EP (3) EP4086278A4 (enExample)
JP (3) JP2023510219A (enExample)
KR (2) KR20220119730A (enExample)
CN (12) CN118754967A (enExample)
AU (2) AU2020418205A1 (enExample)
BR (2) BR112022013150A2 (enExample)
CA (2) CA3166495A1 (enExample)
MX (2) MX2022008130A (enExample)
WO (3) WO2021136293A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118754967A (zh) * 2019-12-30 2024-10-11 甘李药业股份有限公司 胰岛素衍生物
EP4086277A4 (en) * 2019-12-30 2024-02-14 Gan & Lee Pharmaceuticals Co., Ltd. Long-acting glp-1 compound
CA3204051A1 (en) 2021-01-20 2022-07-28 Brian Lian Compositions and methods for the treatment of metabolic and liver disorders
CN115385843A (zh) * 2021-05-24 2022-11-25 广东东阳光药业有限公司 一种新型的酰化胰岛素类似物
AU2022300061A1 (en) * 2021-06-25 2024-02-01 Gan & Lee Pharmaceuticals Co., Ltd. Acylated insulin-containing pharmaceutical composition
JP7642830B2 (ja) 2021-09-15 2025-03-10 バイキング・セラピューティクス・インコーポレイテッド 代謝及び肝臓障害の処置のための組成物及び方法
CN116162147B (zh) * 2021-11-24 2023-10-03 成都奥达生物科技有限公司 一种长效胰岛素类似物
US20250340610A1 (en) * 2022-01-28 2025-11-06 Gan & Lee Pharmaceuticals Co., Ltd. Acylated insulin
WO2024179606A1 (zh) * 2023-03-02 2024-09-06 甘李药业股份有限公司 一种glp-1化合物的医药用途
CN121219311A (zh) * 2023-05-24 2025-12-26 联邦生物科技(珠海横琴)有限公司 一种胰岛素衍生物及其应用
CN116327890B (zh) * 2023-05-29 2023-12-08 北京先为达生物科技有限公司 口服递送的组合物及其应用
CN116789801B (zh) * 2023-08-21 2023-11-14 南京赛诺生物技术有限公司 新型胰岛素衍生物及其用途
WO2025077751A1 (zh) * 2023-10-09 2025-04-17 甘李药业股份有限公司 Glp-1肽组合物及其用途
WO2025098457A1 (zh) * 2023-11-07 2025-05-15 甘李药业股份有限公司 用于降糖的酰化胰岛素
WO2025098502A1 (zh) * 2023-11-08 2025-05-15 甘李药业股份有限公司 包含胰岛素衍生物的药物组合物的治疗用途
WO2025228255A1 (zh) * 2024-04-28 2025-11-06 正大天晴药业集团股份有限公司 酰化人胰岛素类似物

Citations (3)

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JP2014518207A (ja) * 2011-06-15 2014-07-28 ノヴォ ノルディスク アー／エス 多置換インスリン
JP2018508491A (ja) * 2015-01-29 2018-03-29 ノヴォ ノルディスク アー／エス 錠剤コアとポリビニルアルコールコーティングとを含む経口インスリン投与のための医薬組成物

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JP2014518207A (ja) * 2011-06-15 2014-07-28 ノヴォ ノルディスク アー／エス 多置換インスリン
JP2018508491A (ja) * 2015-01-29 2018-03-29 ノヴォ ノルディスク アー／エス 錠剤コアとポリビニルアルコールコーティングとを含む経口インスリン投与のための医薬組成物

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Also Published As

Publication number Publication date
CN114901682A (zh) 2022-08-12
CN118206632A (zh) 2024-06-18
MX2022008130A (es) 2022-10-03
US20250032589A1 (en) 2025-01-30
CN114901683A (zh) 2022-08-12
US20250228919A1 (en) 2025-07-17
BR112022013150A2 (pt) 2023-02-28
CA3166494A1 (en) 2021-07-08
CN114901682B (zh) 2024-04-16
BR112022013009A2 (pt) 2022-09-06
EP4086279A1 (en) 2022-11-09
US20240239862A1 (en) 2024-07-18
WO2021136296A1 (zh) 2021-07-08
EP4086278A1 (en) 2022-11-09
AU2020418205A1 (en) 2022-08-04
CN114901681B (zh) 2024-04-09
CN114901681A (zh) 2022-08-12
WO2021136302A1 (zh) 2021-07-08
KR20220121833A (ko) 2022-09-01
EP4086280A1 (en) 2022-11-09
CN118754967A (zh) 2024-10-11
CN118598978A (zh) 2024-09-06
CN114901683B (zh) 2024-09-13
US20240025957A1 (en) 2024-01-25
CN118420743A (zh) 2024-08-02
AU2020417892A1 (en) 2022-08-25
JP2023510206A (ja) 2023-03-13
WO2021136293A1 (zh) 2021-07-08
CN118480114A (zh) 2024-08-13
KR20220119730A (ko) 2022-08-30
EP4086280A4 (en) 2024-05-29
US12576136B2 (en) 2026-03-17
EP4086279A4 (en) 2024-08-07
CA3166495A1 (en) 2021-07-08
CN118420744A (zh) 2024-08-02
JP2025161829A (ja) 2025-10-24
MX2022008174A (es) 2022-08-02
US20230126068A1 (en) 2023-04-27
CN118666989A (zh) 2024-09-20
EP4086278A4 (en) 2024-08-07
CN118772259A (zh) 2024-10-15
CN118894922A (zh) 2024-11-05

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