KR20220115946A - 안지오텐시노겐 (agt) 관련 장애를 치료하기 위한 방법 및 조성물 - Google Patents

안지오텐시노겐 (agt) 관련 장애를 치료하기 위한 방법 및 조성물 Download PDF

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KR20220115946A
KR20220115946A KR1020227019814A KR20227019814A KR20220115946A KR 20220115946 A KR20220115946 A KR 20220115946A KR 1020227019814 A KR1020227019814 A KR 1020227019814A KR 20227019814 A KR20227019814 A KR 20227019814A KR 20220115946 A KR20220115946 A KR 20220115946A
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nucleotides
subject
nucleotide sequence
modified
antisense strand
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도날드 포스터
사거 아가월
스티븐 앨버트 황
재 김
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알닐람 파마슈티칼스 인코포레이티드
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/52—Methods for regulating/modulating their activity modulating the physical stability, e.g. GC-content

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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020227019814A 2019-11-13 2020-11-06 안지오텐시노겐 (agt) 관련 장애를 치료하기 위한 방법 및 조성물 Pending KR20220115946A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962934695P 2019-11-13 2019-11-13
US62/934,695 2019-11-13
US202063017854P 2020-04-30 2020-04-30
US63/017,854 2020-04-30
PCT/US2020/059265 WO2021096763A1 (en) 2019-11-13 2020-11-06 Methods and compositions for treating an angiotensinogen- (agt-) associated disorder

Publications (1)

Publication Number Publication Date
KR20220115946A true KR20220115946A (ko) 2022-08-19

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KR1020227019814A Pending KR20220115946A (ko) 2019-11-13 2020-11-06 안지오텐시노겐 (agt) 관련 장애를 치료하기 위한 방법 및 조성물

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Country Link
US (1) US20230002765A1 (https=)
EP (1) EP4058577A1 (https=)
JP (1) JP7707164B2 (https=)
KR (1) KR20220115946A (https=)
CN (1) CN114981431A (https=)
AU (1) AU2020382478A1 (https=)
BR (1) BR112022009216A2 (https=)
CL (1) CL2022001256A1 (https=)
CO (1) CO2022006092A2 (https=)
IL (1) IL292865A (https=)
MX (1) MX2022005692A (https=)
PE (1) PE20230179A1 (https=)
PH (1) PH12022551158A1 (https=)
TW (2) TWI877247B (https=)
WO (1) WO2021096763A1 (https=)

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Publication number Priority date Publication date Assignee Title
TWI851574B (zh) 2018-05-14 2024-08-11 美商阿尼拉製藥公司 血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法
AU2022303164A1 (en) * 2021-06-30 2024-01-18 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating an angiotensinogen- (agt-) associated disorder
CN115992138A (zh) * 2021-09-30 2023-04-21 北京安龙生物医药有限公司 用于治疗与pcsk9相关疾病的靶向寡核苷酸
IL312811A (en) 2021-11-16 2024-07-01 Shanghai Argo Biopharmaceutical Co Ltd Composition and method for inhibiting angiotensinogen (agt) protein expression
US20250197853A1 (en) * 2021-11-19 2025-06-19 Tuojie Biotech (Shanghai) Co., Ltd. Sirna targeting angiotensinogen and pharmaceutical use of sirna
WO2023138650A1 (zh) * 2022-01-20 2023-07-27 上海拓界生物医药科技有限公司 一种dsRNA、其应用及制备方法
KR20250023356A (ko) * 2022-04-29 2025-02-18 베이스큐어 테라퓨틱스 뉴클레오타이드 유사체-함유 이중 가닥 RANi 유사체의 접합체
CN119744303A (zh) * 2022-08-11 2025-04-01 益杰立科(上海)生物科技有限公司 一种表观编辑靶点的方法及用途
WO2024234831A1 (zh) * 2023-05-15 2024-11-21 苏州时安生物技术有限公司 一种用于调节血管紧张素原基因表达的双链rna、其缀合物、药物组合物及用途
CN117568350B (zh) * 2024-01-15 2024-04-30 苏州时安生物技术有限公司 一种用于调节血管紧张素原基因表达的双链rna、其缀合物、药物组合物及用途
WO2025007961A1 (zh) * 2023-07-06 2025-01-09 大睿生物 调控AGT表达的dsRNA分子
CN119585433A (zh) * 2023-07-06 2025-03-07 石药集团中奇制药技术（石家庄）有限公司 一种抑制AGT基因表达的RNAi剂及其应用
TW202509216A (zh) * 2023-07-14 2025-03-01 大陸商北京安龍生物醫藥有限公司 靶向血管收縮素原的寡核苷酸及其用途
TW202543655A (zh) * 2023-12-12 2025-11-16 美商艾拉倫製藥股份有限公司 用於治療血管收縮素原（ａｇｔ）相關疾患的方法及組成物
WO2026050125A1 (en) * 2024-08-28 2026-03-05 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating an angiotensinogen- (agt-) associated disorder

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