KR20220093337A - Cd38 녹아웃 일차 및 확장된 인간 nk 세포의 생성 - Google Patents

Cd38 녹아웃 일차 및 확장된 인간 nk 세포의 생성 Download PDF

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KR20220093337A
KR20220093337A KR1020227018144A KR20227018144A KR20220093337A KR 20220093337 A KR20220093337 A KR 20220093337A KR 1020227018144 A KR1020227018144 A KR 1020227018144A KR 20227018144 A KR20227018144 A KR 20227018144A KR 20220093337 A KR20220093337 A KR 20220093337A
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cells
cell
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cancer
dara
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딘 앤소니 리
메이삼 나에이미 카라로우디
가브리엘 기아우어
유야 나가이
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더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈
더 존스 홉킨스 유니버시티
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    • A61K40/41—Vertebrate antigens
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C12N2510/00—Genetically modified cells

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  • General Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Developmental Biology & Embryology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020227018144A 2019-10-31 2020-11-02 Cd38 녹아웃 일차 및 확장된 인간 nk 세포의 생성 Ceased KR20220093337A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962928524P 2019-10-31 2019-10-31
US62/928,524 2019-10-31
PCT/US2020/058565 WO2021087466A1 (en) 2019-10-31 2020-11-02 Generation of cd38 knock-out primary and expanded human nk cells

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KR20220093337A true KR20220093337A (ko) 2022-07-05

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US (1) US20220401482A1 (cg-RX-API-DMAC7.html)
EP (1) EP4051297A4 (cg-RX-API-DMAC7.html)
JP (1) JP2022554284A (cg-RX-API-DMAC7.html)
KR (1) KR20220093337A (cg-RX-API-DMAC7.html)
CN (1) CN114867485A (cg-RX-API-DMAC7.html)
AU (1) AU2020375053A1 (cg-RX-API-DMAC7.html)
BR (1) BR112022008215A2 (cg-RX-API-DMAC7.html)
CA (1) CA3156509A1 (cg-RX-API-DMAC7.html)
IL (1) IL292584A (cg-RX-API-DMAC7.html)
MX (1) MX2022005051A (cg-RX-API-DMAC7.html)
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US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
IL303269A (en) 2020-12-03 2023-07-01 Century Therapeutics Inc Genetically engineered cells and uses thereof
TW202241935A (zh) 2020-12-18 2022-11-01 美商世紀治療股份有限公司 具有可調適受體專一性之嵌合抗原受體系統
MX2023014356A (es) * 2021-06-02 2024-02-15 Metagenomi Inc Sistemas crispr de clase ii, tipo v.
KR20240051112A (ko) 2021-07-01 2024-04-19 인답타 세라뷰틱스 인코포레이티드 조작된 자연 살해(nk) 세포 및 관련 방법
WO2023081200A2 (en) * 2021-11-03 2023-05-11 Intellia Therapeutics, Inc. Cd38 compositions and methods for immunotherapy
JP2025001053A (ja) * 2021-11-05 2025-01-08 学校法人東海大学 劇症型ｎｋ白血病に対する治療標的の同定
KR20250029015A (ko) 2022-03-07 2025-03-04 사노피-아벤티스 유.에스. 엘엘씨 다발성 골수종의 치료를 위한, 다른 제제와 조합된 이사툭시맙의 용도
CN114921416B (zh) * 2022-05-12 2023-05-23 广东普罗凯融生物医药科技有限公司 一种nk细胞及其制备方法
US20250375524A1 (en) 2022-06-30 2025-12-11 Indapta Therapeutics, Inc. Combination of engineered natural killer (nk) cells and antibody therapy and related methods
WO2024124242A2 (en) * 2022-12-09 2024-06-13 Research Institute At Nationwide Children's Hospital Combination cd38ko/car ki nk cell immunotherapy for dual targeting with cd38 monoclonal antibodies
US20260207666A1 (en) * 2022-12-09 2026-07-23 Research Institute At Nationwide Children's Hospital Cd38 as integration site for enhanced function of gene-modified immune cells
EP4651880A1 (en) * 2023-01-17 2025-11-26 Research Institute at Nationwide Children's Hospital Methods of targeting glycogen synthase kinase 3 beta in nk cells
CN116679065B (zh) * 2023-07-31 2023-11-14 北京大学人民医院 检测试剂的应用、多发性骨髓瘤治疗预后预测方法及产品
WO2025213127A1 (en) 2024-04-05 2025-10-09 Indapta Therapeutics, Inc. Treatment of autoimmune diseases or conditions with natural killer cells
WO2025245399A1 (en) 2024-05-23 2025-11-27 Indapta Therapeutics, Inc. Method of treating cancer with natural killer cells
WO2026050706A1 (en) * 2024-08-30 2026-03-05 Aventis Inc. Nk cells having reduced cd38 expression and method for producing

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US128A (en) 1837-02-16 Holdback for sleds
FR1601438A (cg-RX-API-DMAC7.html) 1968-10-17 1970-08-24
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EP3154581B1 (en) * 2014-06-16 2019-02-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Blocking cd38 using anti-cd38 f(ab')2 to protect nk cells
US10738278B2 (en) * 2014-07-15 2020-08-11 Juno Therapeutics, Inc. Engineered cells for adoptive cell therapy
JP6754361B2 (ja) * 2014-12-16 2020-09-09 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ 若年型バッテン病のための遺伝子療法
JP7033453B2 (ja) * 2015-06-30 2022-03-10 セレクティス 特異的エンドヌクレアーゼを使用した遺伝子不活化によってｎｋ細胞の機能性を改善する方法
MA42895A (fr) * 2015-07-15 2018-05-23 Juno Therapeutics Inc Cellules modifiées pour thérapie cellulaire adoptive
JP7653759B2 (ja) * 2016-01-20 2025-03-31 フェイト セラピューティクス，インコーポレイテッド 養子免疫療法における免疫細胞調節のための組成物および方法
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AU2019271366B2 (en) * 2018-05-16 2026-02-26 Research Institute At Nationwide Children's Hospital Generation of knock-out primary and expanded human NK cells using Cas9 ribonucleoproteins

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US20220401482A1 (en) 2022-12-22
AU2020375053A1 (en) 2022-05-26
CN114867485A (zh) 2022-08-05
MX2022005051A (es) 2022-08-08
IL292584A (en) 2022-06-01
CA3156509A1 (en) 2021-05-06
BR112022008215A2 (pt) 2022-07-12
JP2022554284A (ja) 2022-12-28
EP4051297A4 (en) 2023-10-18
EP4051297A1 (en) 2022-09-07
WO2021087466A1 (en) 2021-05-06

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