KR20220081988A - Dna 생산을 증진시키는 변형된 박테리아 레트로요소 - Google Patents

Dna 생산을 증진시키는 변형된 박테리아 레트로요소 Download PDF

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KR20220081988A
KR20220081988A KR1020227012030A KR20227012030A KR20220081988A KR 20220081988 A KR20220081988 A KR 20220081988A KR 1020227012030 A KR1020227012030 A KR 1020227012030A KR 20227012030 A KR20227012030 A KR 20227012030A KR 20220081988 A KR20220081988 A KR 20220081988A
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engineered
letron
sequence
gene
cell
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세트 쉬프먼
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더 제이. 데이비드 글래드스톤 인스티튜트, 어 테스터멘터리 트러스트 이스타빌리쉬드 언더 더 윌 오브 제이. 데이비드 글래드스톤
프레지던트 앤드 펠로우즈 오브 하바드 칼리지
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Application filed by 더 제이. 데이비드 글래드스톤 인스티튜트, 어 테스터멘터리 트러스트 이스타빌리쉬드 언더 더 윌 오브 제이. 데이비드 글래드스톤, 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 filed Critical 더 제이. 데이비드 글래드스톤 인스티튜트, 어 테스터멘터리 트러스트 이스타빌리쉬드 언더 더 윌 오브 제이. 데이비드 글래드스톤
Publication of KR20220081988A publication Critical patent/KR20220081988A/ko
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    • C12N9/1241—Nucleotidyltransferases (2.7.7)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid

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  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020227012030A 2019-09-12 2020-09-11 Dna 생산을 증진시키는 변형된 박테리아 레트로요소 Withdrawn KR20220081988A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962899625P 2019-09-12 2019-09-12
US62/899,625 2019-09-12
PCT/US2020/050323 WO2021050822A1 (en) 2019-09-12 2020-09-11 Modified bacterial retroelement with enhanced dna production

Publications (1)

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KR20220081988A true KR20220081988A (ko) 2022-06-16

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KR1020227012030A Withdrawn KR20220081988A (ko) 2019-09-12 2020-09-11 Dna 생산을 증진시키는 변형된 박테리아 레트로요소

Country Status (11)

Country Link
US (3) US20220307007A1 (https=)
EP (1) EP4028512A4 (https=)
JP (2) JP2022548062A (https=)
KR (1) KR20220081988A (https=)
CN (2) CN119859624A (https=)
AU (1) AU2020346880B2 (https=)
BR (1) BR112022004453A2 (https=)
CA (1) CA3154384A1 (https=)
IL (1) IL291128A (https=)
MX (1) MX2022003091A (https=)
WO (1) WO2021050822A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20250042094A (ko) 2023-09-18 2025-03-26 포항공과대학교 산학협력단 Dna 결합 단백질 특이적 결합 부위를 포함하는 조작된 레트론 및 이의 용도
WO2025063625A1 (ko) * 2023-09-18 2025-03-27 포항공과대학교 산학협력단 Dna 결합 단백질 특이적 결합 부위를 포함하는 조작된 레트론 및 이의 용도

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240263173A1 (en) * 2021-08-11 2024-08-08 The Board Of Trustees Of The Leland Stanford Junior University High-throughput precision genome editing in human cells
CN118511225A (zh) * 2021-09-02 2024-08-16 华盛顿大学 多重时间分辨分子信号记录器及相关方法
CA3237482A1 (en) * 2021-11-03 2023-05-11 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Precise genome editing using retrons
US11866728B2 (en) 2022-01-21 2024-01-09 Renagade Therapeutics Management Inc. Engineered retrons and methods of use
EP4499822A1 (en) * 2022-03-25 2025-02-05 The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone Rt-dna fidelity and retron genome editing
WO2023183627A1 (en) * 2022-03-25 2023-09-28 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Production of reverse transcribed dna (rt-dna) using a retron reverse transcriptase from exogenous rna
EP4499839A1 (en) * 2022-03-25 2025-02-05 The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone Methods of assessing engineered retron activity, and uses thereof
US20250230429A1 (en) * 2022-04-07 2025-07-17 The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads Continuous Multiplexed Phage Genome Engineering Using a Retron Editing Template
US20250243516A1 (en) * 2022-08-24 2025-07-31 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Dual Cut Retron Editors for Genomic Insertions and Deletions
WO2025128871A2 (en) 2023-12-13 2025-06-19 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434070A (en) * 1989-02-24 1995-07-18 The University Of Medicine And Dentistry Of New Jersey Reverse transcriptases from Escherichia coli and Myxococcus xanthus
WO2003104470A2 (en) * 2002-06-05 2003-12-18 Her Majesty In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Canada Retrons for gene targeting
US20050026109A1 (en) * 2003-07-30 2005-02-03 Buchanan L. Stephen Multi-tapered dental files
US20170204399A1 (en) * 2014-08-15 2017-07-20 Massachusetts Institute Of Technology Genomically-encoded memory in live cells
KR101922989B1 (ko) * 2016-05-13 2018-11-28 연세대학교 산학협력단 ＣＲＩＳＰＲ／Ｒｅｔｒｏｎ 시스템을 이용한 유전체상의 치환 변이 생성과 추적 방법
ES2985812T3 (es) * 2016-09-09 2024-11-07 The Board Of Trustees Of The Leland Stanfordjunior Univ Edición genómica de precisión de alto rendimiento
US20180127759A1 (en) * 2016-10-28 2018-05-10 Massachusetts Institute Of Technology Dynamic genome engineering
WO2018191525A1 (en) * 2017-04-12 2018-10-18 President And Fellows Of Harvard College Method of recording multiplexed biological information into a crispr array using a retron

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20250042094A (ko) 2023-09-18 2025-03-26 포항공과대학교 산학협력단 Dna 결합 단백질 특이적 결합 부위를 포함하는 조작된 레트론 및 이의 용도
WO2025063625A1 (ko) * 2023-09-18 2025-03-27 포항공과대학교 산학협력단 Dna 결합 단백질 특이적 결합 부위를 포함하는 조작된 레트론 및 이의 용도

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Publication number Publication date
WO2021050822A1 (en) 2021-03-18
MX2022003091A (es) 2022-06-08
AU2020346880A1 (en) 2022-04-21
CA3154384A1 (en) 2021-03-18
JP2022548062A (ja) 2022-11-16
US20230125704A1 (en) 2023-04-27
EP4028512A1 (en) 2022-07-20
IL291128A (en) 2022-05-01
US20250188442A1 (en) 2025-06-12
CN119859624A (zh) 2025-04-22
BR112022004453A2 (pt) 2022-06-21
CN114667344A (zh) 2022-06-24
EP4028512A4 (en) 2023-09-20
AU2020346880B2 (en) 2025-04-03
JP2024102277A (ja) 2024-07-30
US20220307007A1 (en) 2022-09-29

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